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anti-SNCA antibody :: Mouse anti-Human alpha Synuclein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533240
Western Blot (WB)
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

alpha Synuclein (SNCA), Monoclonal Antibody

 Also Known As   

alpha Synuclein antibody

 Product Synonym Names    Monoclonal Synuclein Alpha; Anti-Synuclein Alpha; NACP; SNCA; Non A4 Component Of Amyloid Precursor; PARK1; PARK4; MGC110988; PD1; Synuclein Alpha; Anti Synuclein Alpha
 Product Gene Name   

anti-SNCA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    127750
 3D Structure    ModBase 3D Structure for P37840
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 Clonality    Monoclonal
 Clone Number    2B2D1; 2B2A11
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    SNCA belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
 Immunogen    alpha Synuclein antibody was raised in Mouse using a purified recombinant fragment of SNCA expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-SNCA antibody

   Mouse monoclonal alpha Synucleinantibody
 Product Categories/Family for anti-SNCA antibody    Neuroscience
 Applications Tested/Suitable for anti-SNCA antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-SNCA antibody    ELISA: 1:10,000
IHC: 1:200-1:1000
WB: 1:500-1:2000
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 Western Blot (WB) of anti-SNCA antibody    Western Blot showing SNCA antibody used against truncated SNCA recombinant protein.
anti-SNCA antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for SNCA. It may not necessarily be applicable to this product.
 NCBI GI #    49456267
 NCBI GeneID    6622
 NCBI Accession #    CAG46454.1 [Other Products]
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 UniProt Primary Accession #    P37840 [Other Products]
 UniProt Secondary Accession #    Q13701; Q4JHI3; Q6IAU6; A8K2A4 [Other Products]
 UniProt Related Accession #    P37840 [Other Products]
 Molecular Weight    13,109 Da [Similar Products]
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 NCBI Official Full Name    SNCA, partial
 NCBI Official Synonym Full Names    synuclein, alpha (non A4 component of amyloid precursor)
 NCBI Official Symbol    SNCA [Similar Products]
 NCBI Official Synonym Symbols   
PD1; NACP; PARK1; PARK4
[Similar Products]
 NCBI Protein Information    alpha-synuclein
 UniProt Protein Name    Alpha-synuclein
 UniProt Synonym Protein Names   
Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP
 Protein Family    Alpha-synuclein
 UniProt Gene Name    SNCA [Similar Products]
 UniProt Synonym Gene Names    NACP; PARK1; NACP [Similar Products]
 UniProt Entry Name    SYUA_HUMAN
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 NCBI Summary for SNCA    Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for SNCA    SNCA: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: Golgi apparatus; nuclear outer membrane; mitochondrion; rough endoplasmic reticulum; lysosome; extracellular region; fibril; terminal button; inclusion body; cell cortex; mitochondrial respiratory chain complex I; cytosol; actin cytoskeleton; platelet alpha granule membrane; synaptic vesicle; growth cone; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; ribosome; nucleus; cell junction

Molecular Function: protein domain specific binding; identical protein binding; histone binding; zinc ion binding; kinesin binding; ferrous iron binding; microtubule binding; caspase inhibitor activity; beta-tubulin binding; magnesium ion binding; protein N-terminus binding; phosphoprotein binding; calcium ion binding; oxidoreductase activity; Hsp70 protein binding; dynein binding; protein binding; phospholipase binding; copper ion binding; phospholipid binding; tau protein binding; fatty acid binding; alpha-tubulin binding

Biological Process: regulation of acyl-CoA biosynthetic process; positive regulation of apoptosis; adult locomotory behavior; response to lipopolysaccharide; positive regulation of endocytosis; dopamine biosynthetic process; positive regulation of neurotransmitter secretion; calcium ion homeostasis; response to magnesium ion; fibril organization and biogenesis; synapse organization and biogenesis; dopamine uptake; negative regulation of neuron apoptosis; response to drug; negative regulation of dopamine metabolic process; synaptic vesicle endocytosis; negative regulation of transporter activity; negative regulation of apoptosis; regulation of long-term neuronal synaptic plasticity; negative regulation of serotonin uptake; mitochondrial membrane organization and biogenesis; negative regulation of norepinephrine uptake; microglial cell activation; negative regulation of monooxygenase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; fatty acid metabolic process; regulation of dopamine secretion; negative regulation of histone acetylation; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of protein amino acid phosphorylation; behavioral response to cocaine; receptor internalization; phospholipid metabolic process; response to iron(II) ion; positive regulation of receptor recycling; aging; caspase activation; neutral lipid metabolic process; protein destabilization; negative regulation of microtubule polymerization; regulation of macrophage activation; regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; organelle ATP synthesis coupled electron transport; regulation of locomotion; positive regulation of release of sequestered calcium ion into cytosol; regulation of excitatory postsynaptic membrane potential

Disease: Parkinson Disease 4, Autosomal Dominant; Parkinson Disease 1, Autosomal Dominant; Dementia, Lewy Body
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 Research Articles on SNCA    1. results further show that the common structural feature of the three PD-associated mutants is more compact and rigid sites at their N and C termini compared with WT alpha-Syn
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SNCA antibodyPathways associated with anti-SNCA antibody
 Reference Product  PubMed Publications
 PARK2 antibody  >976 publications with SNCA and PARK2
 MAPT antibody  >88 publications with SNCA and MAPT
 PARK7 antibody  >54 publications with SNCA and PARK7
 SNCAIP antibody  >33 publications with SNCA and SNCAIP
 SLC6A3 antibody  >25 publications with SNCA and SLC6A3
 APP antibody  >18 publications with SNCA and APP
 FYN antibody  >2 publications with SNCA and FYN
 UBC antibody  >1 publications with SNCA and UBC
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
Diseases associated with anti-SNCA antibodyOrgans/Tissues associated with anti-SNCA antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1212 publications with SNCA and Nervous System Diseases
 Brain Diseases Antibodies  >1189 publications with SNCA and Brain Diseases
 Neurodegenerative Diseases Antibodies  >1174 publications with SNCA and Neurodegenerative Diseases
 Movement Disorders Antibodies  >1047 publications with SNCA and Movement Disorders
 Parkinsonian Disorders Antibodies  >970 publications with SNCA and Parkinsonian Disorders
 Parkinson Disease Antibodies  >915 publications with SNCA and Parkinson Disease
 Lewy Body Disease Antibodies  >291 publications with SNCA and Lewy Body Disease
 Nerve Degeneration Antibodies  >170 publications with SNCA and Nerve Degeneration
 Disease Models, Animal Antibodies  >158 publications with SNCA and Disease Models, Animal
 PARKINSON DISEASE 1, AUTOSOMAL DOMINANT Antibodies  >58 publications with SNCA and PARKINSON DISEASE 1, AUTOSOMAL DOMINANT
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1011 publications with SNCA and Nerve
 Brain Antibodies  >842 publications with SNCA and Brain
 Blood Antibodies  >81 publications with SNCA and Blood
 Embryonic Tissue Antibodies  >28 publications with SNCA and Embryonic Tissue
 Kidney Antibodies  >19 publications with SNCA and Kidney
 Heart Antibodies  >11 publications with SNCA and Heart
 Eye Antibodies  >10 publications with SNCA and Eye
 Vascular Antibodies  >9 publications with SNCA and Vascular
 Liver Antibodies  >9 publications with SNCA and Liver
 Skin Antibodies  >8 publications with SNCA and Skin
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