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anti-b-Actin antibody :: Rabbit b-Actin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS684073
Testing Data
Unit / Price
1 ml (Prediluted)  /  $175 +1 FREE 8GB USB
0.04 mL  /  $185 +1 FREE 8GB USB
0.1 mL  /  $275 +1 FREE 8GB USB
7 ml (Prediluted)  /  $285 +1 FREE 8GB USB
0.2 mL  /  $340 +1 FREE 8GB USB
15 ml (Prediluted)  /  $385 +1 FREE 8GB USB
0.5 mL  /  $415 +1 FREE 8GB USB
1 mL  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

b-Actin, Monoclonal Antibody

 Also Known As   

Anti - b-Actin

 Product Gene Name   

anti-b-Actin antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.14 (5527148..5530601, complement). Location: 7p22
 OMIM    102630
 3D Structure    ModBase 3D Structure for P60709
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 Clonality    Monoclonal
 Clone Number    S12-I
 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Specificity    Human
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 Immunogen    Peptide derived from C-terminal sequence of human beta-actin
 Storage Buffer    20 mM Tris-HCl, pH 8.0
 Stabilizer    20 mg/ml BSA
 Preservative    0.05% NaN3
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 Preparation and Storage    Store at +4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Other Notes    Small volumes of anti-b-Actin antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-b-Actin antibody   

Immunohistochemistry (IHC) - Formalin/Paraffin

 Application Notes for anti-b-Actin antibody    IHC-P dilution 1:100 - 1:200; IHC-Fr application and dilution to be tested by the user
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 Testing Data of anti-b-Actin antibody    anti-b-Actin antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for b-Actin. It may not necessarily be applicable to this product.
 NCBI GI #    46397333
 NCBI GeneID    60
 NCBI Accession #    P60709.1 [Other Products]
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 UniProt Primary Accession #    P60709 [Other Products]
 UniProt Secondary Accession #    P02570; P70514; P99021; Q11211; Q64316; Q75MN2; Q96B34; Q96HG5 [Other Products]
 UniProt Related Accession #    P60709 [Other Products]
 Molecular Weight    41,737 Da
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 NCBI Official Full Name    Actin, cytoplasmic 1
 NCBI Official Synonym Full Names    actin, beta
 NCBI Official Symbol    ACTB [Similar Products]
 NCBI Official Synonym Symbols   
BRWS1; PS1TP5BP1
[Similar Products]
 NCBI Protein Information    actin, cytoplasmic 1; beta cytoskeletal actin; PS1TP5-binding protein 1
 UniProt Protein Name    Actin, cytoplasmic 1
 UniProt Synonym Protein Names   
Beta-actin
 UniProt Gene Name    ACTB [Similar Products]
 UniProt Entry Name    ACTB_HUMAN
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 NCBI Summary for b-Actin    This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for b-Actin    Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Subunit structure: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of KMT2E/MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM. Ref.11 Ref.12 Ref.14 Ref.15 Ref.16 Ref.18 Ref.21

Subcellular location: Cytoplasm › cytoskeleton. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref.15

Post-translational modification: ISGylated. Ref.13Oxidation of Met-44 and Met-47 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization

By similarity.Monomethylation at Lys-84 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.

Involvement in disease: Dystonia, juvenile-onset (DYTJ) [MIM:607371]: A form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. Patients with juvenile-onset dystonia manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20Baraitser-Winter syndrome 1 (BRWS1) [MIM:243310]: A rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23

Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Sequence similarities: Belongs to the actin family.
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 Research Articles on b-Actin    1. chorein interacts with beta-adducin and beta-actin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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