View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Mouse anti-Human b-Amyloid 1-40, 42 Monoclonal Antibody Catalog # MBS601661 Unit / Price 0.1 mL / $905 +1 FREE 8GB USB 5x0.1 mL / $3,905 +4 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name b-Amyloid 1-40, 42, Monoclonal Antibody Popular Item Full Product Name b-Amyloid 1-40, 42 Product Synonym Names Anti -b-Amyloid 1-40, 42 Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP MBS601661 COA COA PDF Clonality Monoclonal Isotype IgG1 Clone Number 3H2 Host Mouse Species Reactivity Human Specificity Recognizes human b-amyloid 1-40/42. Purity/Purification Ascites Form/Format Supplied as a liquid, 0.05% sodium azide. Immunogen Human beta Amyloid 1-40, conjugated to KLH. Epitope: Localized to the N-terminus of beta amyloid (1-13aa of 1-40/42/43). Species Sequence Homology: mouse, rat and many other species. Recommended Control Peptide Full length β-amyloid (1-40aa and 1-42aa) Preparation and Storage May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap Other Notes Small volumes of anti-b-Amyloid 1-40, 42 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-b-Amyloid 1-40, 42 antibody Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognition in the elderly. One of the most important and initial step involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43aa peptides (beta amyloid1-40, 1-42 and 1-43). Polymerization of b-amyloid (Ab) and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition. Ab deposits have also been found to contain 2 additional proteins termed a-synuclein and b-synuclein. The 140aa a-synucleins is identical with non- Ab component (NACP) of AD. The 134aa human b-synuclein is homologous to 14kD bovine phosphoneuroprotein 14. Mutations in a-synuclein gene causing a replacement of alanine with a threonine may cause the protein to misfold. Synucleins are primarily expressed in the brain. At least 3 forms: two large (140 aa SYN-1 & 149 aa SYN-2) and a small form (SYN-3, 42 aa) are produced by alternative splicing. Product Categories/Family for anti-b-Amyloid 1-40, 42 antibody Antibodies; Abs to Amyloid Applications Tested/Suitable for anti-b-Amyloid 1-40, 42 antibody Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Application Notes for anti-b-Amyloid 1-40, 42 antibody ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/wellWestern Blot: 1:1000-1:5000 (ECL)Immunohistochemistry: 1:500-1000 using formalin or paraformaldehyde-fixed Alzheimers brains.Optimal dilutions to be determined by the researcher. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP