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anti-HLA-G antibody :: Mouse anti-Human b2-Microglobulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS645453 anti-HLA-G antibody
Unit / Price
0.2 mL  /  $655 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

b2-Microglobulin (HLA-G), Monoclonal Antibody

 Also Known As   

b2-Microglobulin (B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P) (HRP)

 Product Synonym Names    Anti -b2-Microglobulin (B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P) (HRP)
 Product Gene Name   

anti-HLA-G antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (29794756..29798899). Location: 6p21.3
 OMIM    142871
 3D Structure    ModBase 3D Structure for P17693
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    12K274
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human B2M.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in 0.01M PBS, pH 7.0 ± 0.1, 50% glycerol. Labeled with horseradish peroxidase (HRP).
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 Immunogen    Recombinant corresponding to human B2M.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.
 Other Notes    Small volumes of anti-HLA-G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HLA-G antibody

   b2-microglobulin non-covalently associates with the 44kD a-chain to form the HLA Class I antigen complex. Human b2-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.
 Product Categories/Family for anti-HLA-G antibody    Antibodies; Abs to Serum Proteins
 Applications Tested/Suitable for anti-HLA-G antibody   

ELISA (EL/EIA)

 Application Notes for anti-HLA-G antibody    Suitable for use in ELISA.
Dilution: ELISA: 1:1000
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NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.
 NCBI GI #    188468
 NCBI GeneID    3135
 NCBI Accession #    AAA59836.1 [Other Products]
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 UniProt Primary Accession #    P17693 [Other Products]
 UniProt Related Accession #    P17693 [Other Products]
 Molecular Weight    38,224 Da [Similar Products]
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 NCBI Official Full Name    b2 microglobulin
 NCBI Official Synonym Full Names    major histocompatibility complex, class I, G
 NCBI Official Symbol    HLA-G [Similar Products]
 NCBI Official Synonym Symbols   
MHC-G
[Similar Products]
 NCBI Protein Information    HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G
 UniProt Protein Name    HLA class I histocompatibility antigen, alpha chain G
 UniProt Synonym Protein Names   
HLA G antigen; MHC class I antigen G
 Protein Family    HLA class I histocompatibility antigen
 UniProt Gene Name    HLA-G [Similar Products]
 UniProt Synonym Gene Names    HLA-6.0; HLAG [Similar Products]
 UniProt Entry Name    HLAG_HUMAN
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 NCBI Summary for HLA-G    HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HLA-G    HLA-G: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. Belongs to the MHC class I family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; plasma membrane; MHC class I protein complex

Molecular Function: protein homodimerization activity; peptide antigen binding; receptor binding

Biological Process: immune response-inhibiting cell surface receptor signaling pathway; regulation of immune response; positive regulation of regulatory T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tolerance induction; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of T cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular defense response; positive regulation of T cell tolerance induction

Disease: Asthma, Susceptibility To
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 Research Articles on HLA-G    1. This meta-analysis suggests that the 14 bp insertion/deletion HLA-G allele is associated with increased risk of unexplained recurrent spontaneous abortion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HLA-G antibodyPathways associated with anti-HLA-G antibody
 Reference Product  PubMed Publications
 CD4 antibody  >89 publications with HLA-G and CD4
 IL10 antibody  >75 publications with HLA-G and IL10
 LILRB2 antibody  >40 publications with HLA-G and LILRB2
 KLRC1 antibody  >11 publications with HLA-G and KLRC1
 LIF antibody  >11 publications with HLA-G and LIF
 ADM2 antibody  >2 publications with HLA-G and ADM2
 SPRY2 antibody  >1 publications with HLA-G and SPRY2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-HLA-G antibodyOrgans/Tissues associated with anti-HLA-G antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >325 publications with HLA-G and Neoplasms
 Adenocarcinoma Antibodies  >84 publications with HLA-G and Adenocarcinoma
 Skin Diseases Antibodies  >63 publications with HLA-G and Skin Diseases
 Inflammation Antibodies  >61 publications with HLA-G and Inflammation
 Necrosis Antibodies  >43 publications with HLA-G and Necrosis
 Nervous System Diseases Antibodies  >34 publications with HLA-G and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >31 publications with HLA-G and Gastrointestinal Diseases
 Asthma Antibodies  >27 publications with HLA-G and Asthma
 Breast Neoplasms Antibodies  >24 publications with HLA-G and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >24 publications with HLA-G and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >442 publications with HLA-G and Placenta
 Lung Antibodies  >33 publications with HLA-G and Lung
 Brain Antibodies  >27 publications with HLA-G and Brain
 Thymus Antibodies  >22 publications with HLA-G and Thymus
 Stomach Antibodies  >8 publications with HLA-G and Stomach
 Intestine Antibodies  >7 publications with HLA-G and Intestine
 Testis Antibodies  >5 publications with HLA-G and Testis
 Pancreas Antibodies  >3 publications with HLA-G and Pancreas
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