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anti-bFGF antibody :: Mouse bFGF Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS592112
Testing Data
Unit / Price
0.5 mg  /  $490 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

bFGF, Monoclonal Antibody

 Also Known As   

mAb anti-Human bFGF

 Product Synonym Names    Fibroblast Growth Factor - Basic (bFGF); Mouse monoclonal antibody to human fibroblast growth factor basic (bFGF)
 Product Gene Name   

anti-bFGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    134920
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    F-3
 Host    Mouse
 Species Reactivity    Human. Other species not tested
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 Specificity    Fibroblast Growth Factor - Basic (bFGF)
 Purity/Purification    Protein G affinity purified
 Form/Format    Lyophilized from a solution in 0.01M PBS, pH 7.2.
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 Target Protein    Human bFGF
 Immunogen    Purified recombinant human bFGF
 Myeloma    Sp2/0-Ag14
 Light Chain    Kappa
 Reconstitution    Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
 Research Area    Cytokine, growth Factor
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-bFGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-bFGF antibody

   Mouse monoclonal antibody to human fibroblast growth factor basic (bFGF), protein G affinity purified
 Product Categories/Family for anti-bFGF antibody    Primary antibodies; Monoclonal Antibodies to Human Cytokines and Growth Factors
 Applications Tested/Suitable for anti-bFGF antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-bFGF antibody    ELISA: The antibody is reactive to recombinant bFGF.
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 Testing Data of anti-bFGF antibody    anti-bFGF antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for bFGF. It may not necessarily be applicable to this product.
 NCBI GI #    8250666
 NCBI GeneID    2247
 NCBI Accession #    AAB21432.2 [Other Products]
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 UniProt Secondary Accession #    O00527; P78443; Q16443; Q5PY50; Q7KZ11; Q7KZ72; Q9UC54; Q9UCS5; Q9UCS6; A4LBB8 [Other Products]
 UniProt Related Accession #    P09038 [Other Products]
 Molecular Weight    21,203 Da
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 NCBI Official Full Name    basic fibroblast growth factor, partial
 NCBI Official Synonym Full Names    fibroblast growth factor 2 (basic)
 NCBI Official Symbol    FGF2 [Similar Products]
 NCBI Official Synonym Symbols   
BFGF; FGFB; FGF-2; HBGF-2
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 2; basic fibroblast growth factor bFGF; heparin-binding growth factor 2; prostatropin
 UniProt Protein Name    Fibroblast growth factor 2
 UniProt Synonym Protein Names   
Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
 UniProt Gene Name    FGF2 [Similar Products]
 UniProt Entry Name    FGF2_HUMAN
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 NCBI Summary for bFGF    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
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 UniProt Comments for bFGF    FGF2: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Activator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: extracellular space; extracellular region; nucleus

Molecular Function: heparin binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; growth factor activity; cytokine activity; fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; wound healing; somatic stem cell maintenance; activation of MAPK activity; positive regulation of transcription, DNA-dependent; signal transduction; chemotaxis; hyaluronan catabolic process; growth factor dependent regulation of satellite cell proliferation; positive regulation of MAP kinase activity; positive chemotaxis; positive regulation of cell proliferation; embryonic morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; nervous system development; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of cell fate specification; positive regulation of blood vessel endothelial cell migration; positive regulation of phosphoinositide 3-kinase activity; negative regulation of blood vessel endothelial cell migration; regulation of angiogenesis; positive regulation of angiogenesis; organ morphogenesis; cell migration during sprouting angiogenesis; ureteric bud branching; positive regulation of cell division; release of sequestered calcium ion into cytosol; Ras protein signal transduction; phosphatidylinositol biosynthetic process; insulin receptor signaling pathway; innate immune response; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; inositol phosphate biosynthetic process
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 Research Articles on bFGF    1. Angiogenic proteins, vascular endothelial growth factor, basic fibroblast growth factor and epithelial growth factor receptor are expressed in peripheral nerve sheath tumors of neurofibromatosis type 1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-bFGF antibodyDiseases associated with anti-bFGF antibody
 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >986 publications with bFGF and Nervous System Diseases
 Necrosis Antibodies  >618 publications with bFGF and Necrosis
 Wounds and Injuries Antibodies  >577 publications with bFGF and Wounds and Injuries
 Inflammation Antibodies  >444 publications with bFGF and Inflammation
 Heart Diseases Antibodies  >420 publications with bFGF and Heart Diseases
 Myocardial Ischemia Antibodies  >347 publications with bFGF and Myocardial Ischemia
 Disease Progression Antibodies  >340 publications with bFGF and Disease Progression
 Lung Diseases Antibodies  >328 publications with bFGF and Lung Diseases
 Hyperplasia Antibodies  >258 publications with bFGF and Hyperplasia
 Lung Neoplasms Antibodies  >226 publications with bFGF and Lung Neoplasms
Organs/Tissues associated with anti-bFGF antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >4719 publications with bFGF and Vascular
 Brain Antibodies  >2182 publications with bFGF and Brain
 Bone Antibodies  >1825 publications with bFGF and Bone
 Muscle Antibodies  >1802 publications with bFGF and Muscle
 Embryonic Tissue Antibodies  >1273 publications with bFGF and Embryonic Tissue
 Eye Antibodies  >1024 publications with bFGF and Eye
 Skin Antibodies  >824 publications with bFGF and Skin
 Connective Tissue Antibodies  >713 publications with bFGF and Connective Tissue
 Bone Marrow Antibodies  >659 publications with bFGF and Bone Marrow
 Heart Antibodies  >654 publications with bFGF and Heart
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