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anti-B2M antibody :: Mouse anti-Chicken beta 2-Microglobulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673937
Testing Data
Unit / Price
0.5 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta 2-Microglobulin (B2M), Monoclonal Antibody

 Also Known As   

Mouse Anti-Chicken b2-microglobulin-FITC

 Product Synonym Names    Mouse Anti-Chicken b2-microglobulin - FITC; Mouse Anti-Chicken beta 2-Microglobulin
 Product Gene Name   

anti-B2M antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (45003685..45010357). Location: 15q21-q22.2
 OMIM    109700
 3D Structure    ModBase 3D Structure for P61769
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 Clonality    Monoclonal
 Isotype    Mouse IgG1 kappa
 Clone Number    F21-21
 Host    Mouse
 Species Reactivity    Chicken
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 Specificity    The beta 2-microglobulin subunit (Mr ~ 14 kDa) of avian MHC Class I molecules
Like their mammalian counterparts, avian MHC Class I molecules (also known as B-F antigens) consist of a highly polymorphic alpha -chain (Mr ~ 44 kDa) non-covalently bound to the invariant beta 2-microglobulin subunit (Mr ~ 14 kDa). MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells.1-2 MAb F21-21 also reacts with turkey beta 2-microglobulin.3
 Form/Format    Fluorescein (FITC) Conjugate
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 Characterization    To ensure optimal performance, each batch of monoclonal antibody is tested by flow cytometry to conform to characteristics of a standard reference reagent. Representative flow data are included on page 2 of this product insert.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugate is supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
Protect conjugated forms from light. Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-B2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-B2M antibody   

Flow Cytometry; Immunohistochemistry; Immunoprecipitation; Western Blot; Immunoaffinity Chromatography

 Application Notes for anti-B2M antibody    Flow Cytometry Suggested Dilution: <= 1 ug/10^6 cells
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 Testing Data of anti-B2M antibody    anti-B2M antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for B2M. It may not necessarily be applicable to this product.
 NCBI GI #    179318
 NCBI GeneID    567
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 UniProt Primary Accession #    P61769 [Other Products]
 UniProt Secondary Accession #    P01884; Q540F8; Q6IAT8; Q9UCK0; Q9UD48; Q9UDF4 [Other Products]
 UniProt Related Accession #    P61769; Q16446; Q9UM88 [Other Products]
 Molecular Weight    13,715 Da [Similar Products]
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 NCBI Official Full Name    beta-2-microglobulin
 NCBI Official Synonym Full Names    beta-2-microglobulin
 NCBI Official Symbol    B2M [Similar Products]
 NCBI Official Synonym Symbols   
B2M
[Similar Products]
 NCBI Protein Information    beta-2-microglobulin; OTTHUMP00000161912; beta-2-microglobin; beta chain of MHC class I molecules
 UniProt Protein Name    Beta-2-microglobulin
 Protein Family    Beta-2-microglobulin
 UniProt Gene Name    B2M [Similar Products]
 UniProt Entry Name    B2MG_HUMAN
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 NCBI Summary for B2M    This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
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 UniProt Comments for B2M    Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subunit structure: Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Ref.14

Subcellular location: Secreted. Note: Detected in serum and urine. Ref.16 Ref.17

Post-translational modification: Glycation of Ile-21 is observed in long-term hemodialysis patients.

Involvement in disease: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [

MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. Ref.33Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.30 Ref.31 Ref.32

Sequence similarities: Belongs to the beta-2-microglobulin family.Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
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Product References and Citations for anti-B2M antibody

   1. Skjodt, K., K.G. Welinder, M.Crone, S. Verland, J. Salomonsen, and M. Simonsen. 1986. Mol. Immunol. 23:1301-1309.
2. Dunon, D., J. Kaufman, J. Salomonsen, K. Skjodt, O. Vainio, J.P. Thiery, and B.A. Imhof. 1990. EMBO J. 9:3315-3322.
4. Salomonsen, J. Personal communication.
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 Research Articles on B2M    1. B2M was upregulated in ureteropelvic junction obstruction and decreased after surgical treatment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-B2M antibodyPathways associated with anti-B2M antibody
 Reference Product  PubMed Publications
 HLA-A antibody  >10 publications with B2M and HLA-A
 HLA-B antibody  >8 publications with B2M and HLA-B
 HLA-G antibody  >4 publications with B2M and HLA-G
 HLA-C antibody  >2 publications with B2M and HLA-C
 HFE antibody  >2 publications with B2M and HFE
 HLA-E antibody  >1 publications with B2M and HLA-E
 FCGRT antibody  >1 publications with B2M and FCGRT
 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
Diseases associated with anti-B2M antibodyOrgans/Tissues associated with anti-B2M antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >148 publications with B2M and Neoplasms
 Male Urogenital Diseases Antibodies  >76 publications with B2M and Male Urogenital Diseases
 Female Urogenital Diseases Antibodies  >71 publications with B2M and Female Urogenital Diseases
 Cardiovascular Diseases Antibodies  >56 publications with B2M and Cardiovascular Diseases
 Kidney Diseases Antibodies  >53 publications with B2M and Kidney Diseases
 Leukemia Antibodies  >42 publications with B2M and Leukemia
 Lymphoma Antibodies  >26 publications with B2M and Lymphoma
 Renal Insufficiency Antibodies  >20 publications with B2M and Renal Insufficiency
 Inflammation Antibodies  >19 publications with B2M and Inflammation
 HIV Infections Antibodies  >16 publications with B2M and HIV Infections
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >210 publications with B2M and Blood
 Kidney Antibodies  >78 publications with B2M and Kidney
 Bone Antibodies  >56 publications with B2M and Bone
 Bone Marrow Antibodies  >43 publications with B2M and Bone Marrow
 Liver Antibodies  >30 publications with B2M and Liver
 Skin Antibodies  >22 publications with B2M and Skin
 Heart Antibodies  >19 publications with B2M and Heart
 Brain Antibodies  >18 publications with B2M and Brain
 Muscle Antibodies  >17 publications with B2M and Muscle
 Spleen Antibodies  >14 publications with B2M and Spleen
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