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anti-TUBB antibody :: beta-Tubulin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS475115
Unit / Price
0.1 mL  /  $335 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

beta-Tubulin (TUBB), Monoclonal Antibody

 Also Known As   

Anti-beta-Tubulin Mouse mAb

 Product Synonym Names    beta 4 tubulin; Beta 5 tubulin; beta Ib tubulin; M40; TUBB1; TUBB5; tubulin beta 1 chain; Tubulin beta 4 chain; tubulin beta 5 chain; Tubulin beta; Tubulin beta chain; tubulin beta polypeptide
 Product Gene Name   

anti-TUBB antibody

[Similar Products]
 Product Synonym Gene Name    M40; TUBB1; TUBB5; OK/SW-cl.56 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    J00314 Genomic DNA
 3D Structure    ModBase 3D Structure for P07437
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1E1-E8-H4
 Host    Mouse
Source: Human
 Species Reactivity    Human, Mouse, Monkey, Goat, Hamster, Rat, Chlamydomonas
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 Purity/Purification    Affinity Purified
 Form/Format    Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide, 0.1mg/mlBSA and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    Purified recombinant human Tubulin beta protein fragments expressed in E Coli.
 Sensitivity    This antibody detects endogenous levels of Tubulin beta and does not cross-react with related proteins.
 Sequence Similarities    Belongs to the tubulin family.
 Subunit Structure    Dimer of alpha and beta chains.May interact with RNABP10 By similarity.Interacts with PIFO.Interacts with MX1.
 Subcellular Location    Cytoplasm; cytoskeleton.
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 Other Notes    Small volumes of anti-TUBB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TUBB antibody

   UniPort Summary Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
 Product Categories/Family for anti-TUBB antibody    Signal Transduction; Cytoskeleton / ECM; Cytoskeleton; Microtubules; Tubulin; Tags & Cell Markers; Subcellular Markers; Cytoskeleton; Microtubules
 Applications Tested/Suitable for anti-TUBB antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-TUBB antibody    WB: 1:5000
ICC: 1:500
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 Western Blot (WB) of anti-TUBB antibody    Western blot detection of Tubulin beta in COS7, LNCap, MCF7 and C2C12 cell lysates and using Tubulin beta mouse mAb (1:5000 diluted).Predicted band size: 55KDa.Observed band size: 55KDa.
anti-TUBB antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-TUBB antibody    Immunocytochemistry staining of HeLa cells fixed with 4% paraformaldehyde and using anti-Tubulin beta mouse mAb (dilution 1:500).
anti-TUBB antibody Immunocytochemistry (ICC) (ICC) image
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 Testing Data of anti-TUBB antibody    Tubulin beta antibody's stability test under 37 degree C 50 hours compare to 4 degree C 50 hours.
anti-TUBB antibody Testing Data image
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 Western Blot (WB) of anti-TUBB antibody    Western blot detection of Tubulin beta in goat intestine, goat skeletal muscle, goat spleen and goat lung cell lysates using Tubulin beta mouse mAb (1:5000-1:10000 diluted).Predicted band size: 55KDa.Observed band size: 55KDa.
anti-TUBB antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-TUBB antibody    Western blot detection of Tubulin beta in Goat skeletal muscle, CHO-k1, COS7, C6, 3T3 and K562 cell lysates using Tubulin beta mouse mAb (1:5000 diluted).Predicted band size:55KDa.Observed band size:55KDa.Exposure time:10sec.
anti-TUBB antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-TUBB antibody    Western blot detection of beta Tubulin in Chlamydomonas cell lysates using beta Tubulin mouse mAb (1:1000 diluted).Predicted band size:55KDa.Observed band size:55KDa.
anti-TUBB antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for TUBB. It may not necessarily be applicable to this product.
 NCBI GI #    645912968
 NCBI GeneID    203068
 NCBI Accession #    NP_001280141.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_178014 [Other Products]
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 UniProt Primary Accession #    P07437 [Other Products]
 UniProt Secondary Accession #    P05218; Q8WUC1; Q9CY33 [Other Products]
 UniProt Related Accession #    P07437 [Other Products]
 Molecular Weight    55
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 NCBI Official Full Name    tubulin beta chain isoform a
 NCBI Official Synonym Full Names    tubulin beta class I
 NCBI Official Symbol    TUBB [Similar Products]
 NCBI Official Synonym Symbols   
M40; TUBB1; TUBB5; CDCBM6; CSCSC1; OK/SW-cl.56
[Similar Products]
 NCBI Protein Information    tubulin beta chain
 UniProt Protein Name    Tubulin beta chain
 UniProt Synonym Protein Names   
Tubulin beta-5 chain
 Protein Family    Tubulin
 UniProt Gene Name    TUBB [Similar Products]
 UniProt Synonym Gene Names    TUBB5 [Similar Products]
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 NCBI Summary for TUBB    This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
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 UniProt Comments for TUBB    TUBB: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. May interact with RNABP10. Interacts with PIFO/C1orf88. Ubiquitously expressed with highest levels in spleen, thymus and immature brain. Belongs to the tubulin family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p21.33

Cellular Component: cytoskeleton; extracellular matrix; extracellular region; microtubule; nuclear envelope lumen; nucleus

Molecular Function: MHC class I protein binding; protein binding; structural molecule activity; ubiquitin protein ligase binding

Biological Process: cell division; cell motility; cellular process; cytoskeleton-dependent intracellular transport; G2/M transition of mitotic cell cycle; microtubule-based process

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 6; Skin Creases, Congenital Symmetric Circumferential, 1
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 Research Articles on TUBB    1. Data suggest a looser binding of the ligand in tubulin mutants.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TUBB antibodyPathways associated with anti-TUBB antibody
 Reference Product  PubMed Publications
 ACTB antibody  >18 publications with TUBB and ACTB
 ACTG1 antibody  >3 publications with TUBB and ACTG1
 AKT1 antibody  >1 publications with TUBB and AKT1
 Products by Pathway  Pathway Diagram
 AURKA Activation By TPX2 Pathway antibodies  AURKA Activation By TPX2 Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 Cilium Assembly Pathway antibodies  Cilium Assembly Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-TUBB antibodyOrgans/Tissues associated with anti-TUBB antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >12 publications with TUBB and Nervous System Diseases
 Lung Diseases Antibodies  >10 publications with TUBB and Lung Diseases
 Lung Neoplasms Antibodies  >8 publications with TUBB and Lung Neoplasms
 Adenocarcinoma Antibodies  >7 publications with TUBB and Adenocarcinoma
 Brain Diseases Antibodies  >7 publications with TUBB and Brain Diseases
 Fibrosis Antibodies  >5 publications with TUBB and Fibrosis
 Neoplasms, Experimental Antibodies  >4 publications with TUBB and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >4 publications with TUBB and Ovarian Neoplasms
 Inflammation Antibodies  >4 publications with TUBB and Inflammation
 Carcinoma, Squamous Cell Antibodies  >4 publications with TUBB and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >24 publications with TUBB and Blood
 Bone Antibodies  >16 publications with TUBB and Bone
 Brain Antibodies  >15 publications with TUBB and Brain
 Lung Antibodies  >11 publications with TUBB and Lung
 Liver Antibodies  >8 publications with TUBB and Liver
 Vascular Antibodies  >7 publications with TUBB and Vascular
 Bone Marrow Antibodies  >6 publications with TUBB and Bone Marrow
 Muscle Antibodies  >5 publications with TUBB and Muscle
 Intestine Antibodies  >5 publications with TUBB and Intestine
 Eye Antibodies  >4 publications with TUBB and Eye
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