View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List Rabbit anti-Human c-Abl Monoclonal Antibody Catalog # MBS607181 Unit / Price 0.1 mL / $800 +1 FREE 8GB USB 5x0.1 mL / $3,420 +4 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name c-Abl, Monoclonal Antibody Full Product Name c-Abl, phosphorylated (Tyr89) (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl) Product Synonym Names Anti -c-Abl, phosphorylated (Tyr89) (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Monoclonal Isotype IgG Clone Number 10g161 Host Rabbit Species Reactivity Human Specificity Recognizes endogenous levels of c-Abl only when phosphorylated at Tyr89. This antibody may cross-react with other tyrosine-phosphorylated proteins. Purity/Purification SupernatantSupernatant Form/Format Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, < 0.02% sodium azide, 50% glycerol. Immunogen Synthetic phosphopeptide corresponding to residues surrounding Tyr89 of human c-Abl. Preparation and Storage May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Other Notes Small volumes of anti-c-Abl antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-c-Abl antibody The c-Abl proto-oncogene encodes a nonreceptor protein tyrosine kinase that is ubiquitously expressed and highly conserved in metazoan evolution. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. It is implicated in regulating cell proliferation, differentiation, apoptosis, cell adhesion and stress responses (1-3). c-Abl kinase activity is increased in vivo by diverse physiological stimuli including integrin activation, PDGF stimulation and binding to c-Jun, Nck and RFX1 (2,4). The in vivo mechanism of regulation of c-Abl kinase activity is not completely understood. Tyr245 is located in the linker region between the SH2 and catalytic domains. This positioning is conserved among Abl family members. Phosphorylation of Tyr245 is involved in the activation of c-Abl kinase (5). In addition, phosphorylation of Tyr412, which is located in the kinase activation loop of c-Abl, is required for kinase activity (6). Product Categories/Family for anti-c-Abl antibody Antibodies; Abs to Apoptosis Applications Tested/Suitable for anti-c-Abl antibody Western Blot (WB) Application Notes for anti-c-Abl antibody Suitable for use in Western Blot.Dilution: Western Blot: 1:1000 Western Blot (WB) of anti-c-Abl antibody Western blot analysis of extract from CML-T1 leukemic cells with MBS607181 (upper and middle) or c-Abl Antibody (lower). The phospho-specificity of this rabbit mAb was verified by treating the membrane with calf intestinal phosphatase (CIP) (middle and lower) before antibody probing. TOP NCBI/Uniprot data below describe general gene information for c-Abl. It may not necessarily be applicable to this product. NCBI GI # 179750 TOP NCBI Official Full Name c-abl TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-c-Abl antibody Reference Product PubMed Publications FLNA antibody >12 publications with c-Abl and FLNA Pathways associated with anti-c-Abl antibody Products by Pathway Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Organs/Tissues associated with anti-c-Abl antibody Organ/Tissue Name Pubmed Publications Bone Antibodies >13 publications with c-Abl and Bone Connective Tissue Antibodies >4 publications with c-Abl and Connective Tissue Heart Antibodies >3 publications with c-Abl and Heart Muscle Antibodies >3 publications with c-Abl and Muscle Brain Antibodies >3 publications with c-Abl and Brain Vascular Antibodies >2 publications with c-Abl and Vascular Embryonic Tissue Antibodies >2 publications with c-Abl and Embryonic Tissue Ear Antibodies >1 publications with c-Abl and Ear Kidney Antibodies >1 publications with c-Abl and Kidney Umbilical Cord Antibodies >1 publications with c-Abl and Umbilical Cord TOP