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anti-CBL antibody :: Mouse c-Cbl (C-terminal Region) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS470005
Testing Data
Unit / Price
0.1 mL  /  $280 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Cbl (C-terminal Region), Monoclonal Antibody

 Also Known As   

Anti-c-Cbl (C-terminal Region)

 Product Synonym Names    c-Cbl (C-terminal Region); E3 ubiquitin-protein ligase CBL; RING finger protein 55
 Product Gene Name   

anti-CBL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (119076990..119178859). Location: 11q23.3
 OMIM    165360
 3D Structure    ModBase 3D Structure for P22681
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 Clonality    Monoclonal
 Isotype    IgG1
 Host    Mouse
 Species Reactivity    Human, Rat, Mouse
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 Specificity    The antibody detects a 120 kDa* protein in human Jurkat cells.
 Purity/Purification    Protein A Purified
 Form/Format    Mouse monoclonal antibody purified with protein A chromatography is supplied in 100ml phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
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 Immunogen    Clone (M159) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of c-Cbl. This sequence is highly conserved in rat and mouse c-Cbl.
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 Preparation and Storage    Store at -20 degree C. Do not aliquot. Stable for 1 year.
 Other Notes    Small volumes of anti-CBL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CBL antibody

   c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that is especially predominant in hematopoietic cells. c-Cbl possesses a highly conserved amino-terminal phosphotyrosine binding domain and a C3HC4 RING finger motif. c-Cbl is rapidly tyrosine phosphorylated in response to stimulation of a variety of cell-surface receptors and becomes associated with a number of intracellular signaling molecules such as protein tyrosine kinases, phosphatidylinositol 3 kinase (PI3K), Crk and 14-3-3 proteins. In human cancer tissues, c-Cbl is frequently tyrosine phosphorylated in a tumor-specific manner. Src-family kinases primarily phosphorylate c- Cbl at Tyr-700, Tyr-731, and Tyr-774. These sites of phosphorylation provide docking sites for downstream signaling components, such as Grb-2, PI3K, and Fyn.
 Applications Tested/Suitable for anti-CBL antibody   

ELISA, Western Blot

 Application Notes for anti-CBL antibody    ELISA: 1:2000
Western Blot: 1:1000
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 Testing Data of anti-CBL antibody    anti-CBL antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for CBL. It may not necessarily be applicable to this product.
 NCBI GI #    29731
 NCBI GeneID    867
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 UniProt Primary Accession #    P22681 [Other Products]
 UniProt Secondary Accession #    A3KMP8 [Other Products]
 UniProt Related Accession #    P22681 [Other Products]
 Molecular Weight    99,633 Da [Similar Products]
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 NCBI Official Full Name    c-cbl
 NCBI Official Synonym Full Names    Cas-Br-M (murine) ecotropic retroviral transforming sequence
 NCBI Official Symbol    CBL [Similar Products]
 NCBI Official Synonym Symbols   
CBL2; NSLL; C-CBL; RNF55
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase CBL; oncogene CBL2; OTTHUMP00000232087; proto-oncogene c-Cbl; RING finger protein 55; signal transduction protein CBL; casitas B-lineage lymphoma proto-oncogene
 UniProt Protein Name    E3 ubiquitin-protein ligase CBL
 UniProt Synonym Protein Names   
Casitas B-lineage lymphoma proto-oncogene; Proto-oncogene c-Cbl; RING finger protein 55; Signal transduction protein CBL
 Protein Family    E3 ubiquitin-protein ligase
 UniProt Gene Name    CBL [Similar Products]
 UniProt Synonym Gene Names    CBL2; RNF55 [Similar Products]
 UniProt Entry Name    CBL_HUMAN
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 NCBI Summary for CBL    The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq]
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 UniProt Comments for CBL    Function: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling. Essential for osteoclastic bone resorption. The Tyr-731 phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Ref.4 Ref.17

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Associates with NCK via its SH3 domain. The phosphorylated C-terminus interacts with CD2AP via its second SH3 domain. Binds to UBE2L3. Interacts with adapters SLA, SLA2 and with the phosphorylated C-terminus of SH2B2. Interacts with EGFR, SYK and ZAP70 via the highly conserved Cbl-N region. Also interacts with SORBS1 and INPPL1/SHIP2. Interacts with phosphorylated LAT2. May interact with CBLB

By similarity. Ref.6 Ref.8 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16

Subcellular location: Cytoplasm.

Domain: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

Post-translational modification: Phosphorylated on tyrosine residues by EGFR, SYK, FYN and ZAP70

By similarity. Phosphorylated on tyrosine residues by INSR. Ref.5 Ref.7 Ref.9 Ref.15 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21 Ref.22 Ref.23 Ref.24

Involvement in disease: Defects in CBL are the cause of Noonan syndrome-like disorder (NSL) [

MIM:613563]. NSL is a syndrome characterized by a phenotype reminiscent of Noonan syndrome. Clinical features are highly variable, including facial dysmorphism, short neck, developmental delay, hyperextensible joints and thorax abnormalities with widely spaced nipples. The facial features consist of triangular face with hypertelorism, large low-set ears, ptosis, and flat nasal bridge. Some patients manifest cardiac defects. Ref.29

Miscellaneous: This protein has one functional calcium-binding site.

Sequence similarities: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.Contains 1 RING-type zinc finger.Contains 1 UBA domain.
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Product References and Citations for anti-CBL antibody

   • Blake, T. J. et al. (1991) Oncogene 6:653.
• Donovan, J.A., et al. (1994) J. Biol. Chem. 269:37.
• Rivero-Lezcano, O.M. et al. (1994) J. Biol. Chem. 269:26.
• Christine, B. F. et al. (2001) Nat. Rev. Mol. Cell Biol. 2:294.
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 Research Articles on CBL    1. In human acute myeloid leukaemias, c-Cbl deletions are not common in the Australian population but they do raise the possibility that they might contribute to the pathogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CBL antibodyPathways associated with anti-CBL antibody
 Reference Product  PubMed Publications
 SRC antibody  >445 publications with CBL and SRC
 EGFR antibody  >203 publications with CBL and EGFR
 GRB2 antibody  >161 publications with CBL and GRB2
 SYK antibody  >120 publications with CBL and SYK
 CRK antibody  >106 publications with CBL and CRK
 CRKL antibody  >66 publications with CBL and CRKL
 FYN antibody  >62 publications with CBL and FYN
 MET antibody  >54 publications with CBL and MET
 LYN antibody  >53 publications with CBL and LYN
 SH3KBP1 antibody  >50 publications with CBL and SH3KBP1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
Diseases associated with anti-CBL antibodyOrgans/Tissues associated with anti-CBL antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >379 publications with CBL and Neoplasms
 Leukemia Antibodies  >168 publications with CBL and Leukemia
 Lymphoma Antibodies  >122 publications with CBL and Lymphoma
 Leukemia, Myeloid Antibodies  >98 publications with CBL and Leukemia, Myeloid
 Nervous System Diseases Antibodies  >94 publications with CBL and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >88 publications with CBL and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >62 publications with CBL and Carcinoma
 Anemia Antibodies  >61 publications with CBL and Anemia
 Lymphoma, B-Cell Antibodies  >48 publications with CBL and Lymphoma, B-Cell
 Leukemia, Myeloid, Acute Antibodies  >43 publications with CBL and Leukemia, Myeloid, Acute
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >676 publications with CBL and Blood
 Bone Antibodies  >118 publications with CBL and Bone
 Brain Antibodies  >104 publications with CBL and Brain
 Liver Antibodies  >93 publications with CBL and Liver
 Kidney Antibodies  >89 publications with CBL and Kidney
 Muscle Antibodies  >85 publications with CBL and Muscle
 Nerve Antibodies  >82 publications with CBL and Nerve
 Bone Marrow Antibodies  >65 publications with CBL and Bone Marrow
 Lung Antibodies  >57 publications with CBL and Lung
 Vascular Antibodies  >49 publications with CBL and Vascular
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