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anti-KIT antibody :: Mouse anti-Chicken c-Kit Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS673954 anti-KIT antibody
Unit / Price
0.5 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Kit, Monoclonal Antibody

 Also Known As   

Mouse Anti-Chicken c-Kit-BIOT

 Product Synonym Names    Mouse Anti-Chicken c-Kit - Biotin; Mouse Anti-Chicken c-Kit
 Product Gene Name   

anti-KIT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (55524095..55606881). Location: 4q11-q12
 OMIM    164920
 3D Structure    ModBase 3D Structure for P10721
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 Clonality    Monoclonal
 Isotype    Mouse (BALB/c) IgG2a kappa
 Clone Number    kit2c75
 Host    Mouse
 Species Reactivity    Chicken
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 Specificity    Chicken c-Kit
c-Kit is a 145 kDa transmembrane receptor-type protein tyrosine kinase encoded by the c-Kit protooncogene and is the receptor for stem cell factor (SCF). 1 c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. 2, 3, 4, 5 The amino acid sequence of chicken c-kit shows 63% identity to mouse c-Kit and exhibits similar expression patterns in RNA blot analysis suggesting similar biological roles.1
 Form/Format    Biotin (BIOT) Conjugate
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 Immunogen    Sp2/0 cells, Sp/chkit4A4, transfected with chicken c-kit cDNA1
 Characterization    To insure acceptable performance, each batch of product is tested by flow cytometry to conform to characteristics of a standard reference reagent.
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 Preparation and Storage    The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C.
The fluorescein (FITC) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The biotin (BIOT) conjugate is supplied as 0.5 mg in 1.0 mL of PBS/NaN3. Store at 2-8 degree C.
The R-phycoerythrin (R-PE) conjugates are supplied as 0.1 mg in 1.0 mL of PBS/NaN3 and a stabilizing agent. Store at 2-8 degree C. Do not freeze!
Each reagent is stable for the period shown on the bottle label if stored as directed.
 Other Notes    Small volumes of anti-KIT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KIT antibody   

Flow Cytometry

 Application Notes for anti-KIT antibody    Flow Cytometry Suggested Dilution: <=1 ug/10^6 cells
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NCBI/Uniprot data below describe general gene information for KIT. It may not necessarily be applicable to this product.
 NCBI GI #    459359
 NCBI GeneID    3815
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 UniProt Primary Accession #    P10721 [Other Products]
 UniProt Secondary Accession #    Q99662; Q9UM99 [Other Products]
 UniProt Related Accession #    P10721; Q14708; Q14709; Q6IQ28; Q8TCG9 [Other Products]
 Molecular Weight    109,865 Da [Similar Products]
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 NCBI Official Full Name    c-Kit
 NCBI Official Synonym Full Names    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 NCBI Official Symbol    KIT [Similar Products]
 NCBI Official Synonym Symbols   
PBT; SCFR; C-Kit; CD117
[Similar Products]
 NCBI Protein Information    mast/stem cell growth factor receptor; OTTHUMP00000158901; OTTHUMP00000218587; proto-oncogene c-Kit; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
 UniProt Protein Name    Mast/stem cell growth factor receptor
 UniProt Synonym Protein Names   
Proto-oncogene c-Kit; Tyrosine-protein kinase Kit
 Protein Family    Mast/stem cell growth factor receptor
 UniProt Gene Name    KIT [Similar Products]
 UniProt Entry Name    KIT_HUMAN
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 NCBI Summary for KIT    This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for KIT    Function: This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure: Interacts with APS. Interacts with MPDZ (via the tenth PDZ domain). Interacts with PTPRU. Ref.7 Ref.8 Ref.9

Subcellular location: Membrane; Single-pass type I membrane protein.

Involvement in disease: Defects in KIT are a cause of piebald trait (PBT) [

MIM:172800]. PBT is an autosomal dominant genetic developmental abnormality of pigmentation characterized by congenital patches of white skin and hair that lack melanocytes. Ref.13 Ref.14 Ref.15 Ref.17 Ref.18 Ref.19 Ref.20 Ref.22 Ref.27Defects in KIT are a cause of gastrointestinal stromal tumor (GIST) [

MIM:606764]. Ref.19 Ref.23 Ref.24 Ref.28 Ref.29Defects in KIT have been associated with testicular tumors (TEST) [

MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms. Ref.19

Sequence similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 protein kinase domain.
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Product References and Citations for anti-KIT antibody

   1. Sasaki, E., H. Okamura, T. Chikamune, Y. Kanai, M. Watanabe, M. Naito, and M. Sakurai. 1993. Gene. 128:257.
2. Yee, N.S., I. Paek, and P. Besmer. 1994. J. Exp. Med. 179:1994.
3. Iemura, A., M. Tsai, A. Ando, B.K. Wershil, and S.J. Galli. 1994. Am. J. Pathol. 144:321.
4. Blume-Jensen, P., L. Claesson-Welsh, A. Siegbahn, K.M. Zsebo, B. Westermark, and C.H. Heldin. 1991. EMBO J. 10:4121.
5. Kinashi, T. and T.A. Springer. 1994. Blood 83:1033.
6. Vainio, O., D. Dunon, F. Aissi, J.P. Dangy, K.M. McNagny, and B.A. Imhof. 1996. J. Cell Biol. 135:1655.
7. Lampisuo, M., K. Katevuo, and O. Lassila. 1998. Scand. J. Immunol. 48:52.
8. Lampisuo, M. J. Liippo, O. Vainio, K.M. McNagny, J. Kulmala, and O. Lassila. 1999. Int. Immunol. 11:63.
9. Schulte, C.E., M. von Lindern, P. Steinlein, H. Beug, and L.M. Wiedemann. 2002. EMBO J. 21:4297.
10. Katevuo, K., B.A. Imhof, R. Boyd, A. Chidgey, A. Bean, D. Dunon, T.W. Gobel, and O. Vainio. 1999. J. Immunol. 162:5685.
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 Research Articles on KIT    1. Genetic KIT aberration is an adverse prognostic factor for melanoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KIT antibodyPathways associated with anti-KIT antibody
 Reference Product  PubMed Publications
 KITLG antibody  >3273 publications with KIT and KITLG
 SRC antibody  >239 publications with KIT and SRC
 JAK2 antibody  >100 publications with KIT and JAK2
 LYN antibody  >46 publications with KIT and LYN
 EPOR antibody  >45 publications with KIT and EPOR
 CBL antibody  >37 publications with KIT and CBL
 STAT1 antibody  >36 publications with KIT and STAT1
 GRB2 antibody  >34 publications with KIT and GRB2
 TEC antibody  >25 publications with KIT and TEC
 PTPN11 antibody  >25 publications with KIT and PTPN11
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
Diseases associated with anti-KIT antibodyOrgans/Tissues associated with anti-KIT antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6845 publications with KIT and Neoplasms
 Gastrointestinal Stromal Tumors Antibodies  >1645 publications with KIT and Gastrointestinal Stromal Tumors
 Leukemia Antibodies  >1548 publications with KIT and Leukemia
 Cardiovascular Diseases Antibodies  >1076 publications with KIT and Cardiovascular Diseases
 Leukemia, Myeloid Antibodies  >961 publications with KIT and Leukemia, Myeloid
 Nervous System Diseases Antibodies  >951 publications with KIT and Nervous System Diseases
 Vascular Diseases Antibodies  >900 publications with KIT and Vascular Diseases
 Lung Diseases Antibodies  >810 publications with KIT and Lung Diseases
 Adenocarcinoma Antibodies  >790 publications with KIT and Adenocarcinoma
 Leukemia, Myeloid, Acute Antibodies  >650 publications with KIT and Leukemia, Myeloid, Acute
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1581 publications with KIT and Muscle
 Liver Antibodies  >1521 publications with KIT and Liver
 Skin Antibodies  >1010 publications with KIT and Skin
 Lung Antibodies  >951 publications with KIT and Lung
 Intestine Antibodies  >888 publications with KIT and Intestine
 Heart Antibodies  >805 publications with KIT and Heart
 Kidney Antibodies  >741 publications with KIT and Kidney
 Brain Antibodies  >682 publications with KIT and Brain
 Spleen Antibodies  >515 publications with KIT and Spleen
 Nerve Antibodies  >503 publications with KIT and Nerve
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