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anti-c-Kit antibody :: Mouse anti-Human c-Kit Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831961
Western Blot (WB)
Unit / Price
0.1 mL  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Kit, Monoclonal Antibody

 Also Known As   

c-Kit antibody

 Product Synonym Names    Monoclonal c-Kit; Anti-c-Kit; C-kit; CD117; Proto-oncogene tyrosine-protein kinase Kit; protein kinase kit; cd117 antigen; receptor tyrosine kinase kit; v-kit; scfr; mast/stem cell growth factor receptor
 Product Gene Name   

anti-c-Kit antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164920
 3D Structure    ModBase 3D Structure for P10721
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    8D7
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    Proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117 is a protein that in humans is encoded by the KIT gene. Multiple transcript variants encoding different isoforms have been found for this gene. CD117 is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. This receptor binds to stem cell factor (a substance that causes certain types of cells to grow). Altered forms of this receptor may be associated with some types of cancer.
 Immunogen    c-Kit antibody was raised in Mouse using a purified recombinant fragment of C-kit expressed in E Coli as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-c-Kit antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-c-Kit antibody

   Mouse monoclonal c-Kit antibody
 Product Categories/Family for anti-c-Kit antibody    Immunology
 Applications Tested/Suitable for anti-c-Kit antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-c-Kit antibody    ELISA: 1:10,000
IHC: 1:200-1:1000
WB: 1:500-1:2000
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 Western Blot (WB) of anti-c-Kit antibody    Western Blot showing C-kit antibody used against truncated C-kit recombinant protein.
anti-c-Kit antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for c-Kit. It may not necessarily be applicable to this product.
 NCBI GI #    459359
 NCBI GeneID    3815
 NCBI Accession #    AAB29529.1 [Other Products]
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 UniProt Primary Accession #    P10721 [Other Products]
 UniProt Secondary Accession #    Q6IQ28; Q99662; Q9UM99; B5A956; D5LXN2; D5M931; F5H8F8 [Other Products]
 UniProt Related Accession #    P10721 [Other Products]
 Molecular Weight    46,658 Da
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 NCBI Official Full Name    c-Kit, partial
 NCBI Official Synonym Full Names    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 NCBI Official Symbol    KIT [Similar Products]
 NCBI Official Synonym Symbols   
PBT; SCFR; C-Kit; CD117
[Similar Products]
 NCBI Protein Information    mast/stem cell growth factor receptor Kit
 UniProt Protein Name    Mast/stem cell growth factor receptor Kit
 UniProt Synonym Protein Names   
Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD_antigen: CD117
 UniProt Gene Name    KIT [Similar Products]
 UniProt Synonym Gene Names    SCFR; SCFR; PBT [Similar Products]
 UniProt Entry Name    KIT_HUMAN
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 NCBI Summary for c-Kit    This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for c-Kit    Kit: a receptor tyrosine kinase and a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors. Receptor for stem cell factor. Plays a critical role in hematopoietic stem cell, mast cell, melanocyte and germ cell development. Ligand binding induces autophosphorylation, dimerization and activation, leading to the recruitment and phosphorylation of downstream SH2-containing signaling components including PLC-gamma, PI3 kinase p85, SHP2 and CrkL, linking c-Kit to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, while mutations that constitutively activate c-Kit can lead to hyperplasia and tumorigenesis. Activating mutations cause >90% of gastrointestinal stromal tumors (GIST); successfully treated with inhibitors Gleevec (imatinib, Glivec) and Sutent (Sutinib, SU11248). Activating mutations also induce mastocytosis. Autocrine/paracrine stimulation may drive some lung and other tumors. Loss of expression associated with melanoma progression. Familial loss of function mutations cause piebaldism, with defects in hair and skin pigmentation due to lack of melanocytes.

Protein type: Protein kinase, tyrosine (receptor); Kinase, protein; Protein kinase, TK; Membrane protein, integral; Oncoprotein; EC 2.7.10.1; TK group; PDGFR family

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular space; internal side of plasma membrane; mast cell granule; integral to membrane; plasma membrane; acrosome; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protease binding; protein-tyrosine kinase activity; cytokine binding; metal ion binding; stem cell factor receptor activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; somatic stem cell maintenance; germ cell programmed cell death; positive regulation of JAK-STAT cascade; lymphoid progenitor cell differentiation; positive regulation of long-term neuronal synaptic plasticity; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of cell shape; epithelial cell proliferation; germ cell migration; somatic stem cell division; erythrocyte differentiation; T cell differentiation; fibroblast growth factor receptor signaling pathway; embryonic hemopoiesis; mast cell chemotaxis; stem cell differentiation; detection of mechanical stimulus involved in sensory perception of sound; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of Stat1 protein; glycosphingolipid metabolic process; positive regulation of transcription factor activity; regulation of pigmentation during development; immature B cell differentiation; mast cell cytokine production; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; signal transduction; ovarian follicle development; positive regulation of MAPKKK cascade; myeloid progenitor cell differentiation; positive regulation of cell proliferation; melanocyte differentiation; negative regulation of programmed cell death; visual learning; hemopoiesis; inflammatory response; positive regulation of Notch signaling pathway; epidermal growth factor receptor signaling pathway; lamellipodium biogenesis; phosphoinositide-mediated signaling; dendritic cell cytokine production; cytokine and chemokine mediated signaling pathway; male gonad development; stem cell maintenance; positive regulation of phosphoinositide 3-kinase activity; mast cell degranulation; regulation of cell proliferation; positive regulation of pseudopodium formation; gut development; pigmentation; positive regulation of tyrosine phosphorylation of Stat5 protein; actin cytoskeleton reorganization; innate immune response; spermatogenesis; spermatid development; positive regulation of cell migration

Disease: Gastrointestinal Stromal Tumor; Mast Cell Disease; Piebald Trait; Testicular Germ Cell Tumor
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 Research Articles on c-Kit    1. C-kit expression is a feature of more aggressive retinoblastomas, with increased expression in tumours spreading beyond the retina.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-c-Kit antibodyPathways associated with anti-c-Kit antibody
 Reference Product  PubMed Publications
 KITLG antibody  >3833 publications with c-Kit and KITLG
 EPOR antibody  >51 publications with c-Kit and EPOR
 STAT1 antibody  >49 publications with c-Kit and STAT1
 GRB2 antibody  >39 publications with c-Kit and GRB2
 PTPN11 antibody  >29 publications with c-Kit and PTPN11
 STAT5B antibody  >12 publications with c-Kit and STAT5B
 PIK3R1 antibody  >5 publications with c-Kit and PIK3R1
 DOK1 antibody  >3 publications with c-Kit and DOK1
 SOCS6 antibody  >2 publications with c-Kit and SOCS6
 PIK3CG antibody  >1 publications with c-Kit and PIK3CG
 Products by Pathway  Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with anti-c-Kit antibodyOrgans/Tissues associated with anti-c-Kit antibody
 Disease Name  Pubmed Publications
 Gastrointestinal Stromal Tumors Antibodies  >2324 publications with c-Kit and Gastrointestinal Stromal Tumors
 Inflammation Antibodies  >1358 publications with c-Kit and Inflammation
 Nervous System Diseases Antibodies  >1350 publications with c-Kit and Nervous System Diseases
 Liver Diseases Antibodies  >1328 publications with c-Kit and Liver Diseases
 Lung Diseases Antibodies  >1252 publications with c-Kit and Lung Diseases
 Necrosis Antibodies  >1166 publications with c-Kit and Necrosis
 Leukemia, Myeloid, Acute Antibodies  >899 publications with c-Kit and Leukemia, Myeloid, Acute
 Heart Diseases Antibodies  >879 publications with c-Kit and Heart Diseases
 Breast Neoplasms Antibodies  >719 publications with c-Kit and Breast Neoplasms
 Lung Neoplasms Antibodies  >689 publications with c-Kit and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2310 publications with c-Kit and Muscle
 Liver Antibodies  >2155 publications with c-Kit and Liver
 Skin Antibodies  >1589 publications with c-Kit and Skin
 Lung Antibodies  >1529 publications with c-Kit and Lung
 Heart Antibodies  >1365 publications with c-Kit and Heart
 Intestine Antibodies  >1153 publications with c-Kit and Intestine
 Brain Antibodies  >1076 publications with c-Kit and Brain
 Kidney Antibodies  >1069 publications with c-Kit and Kidney
 Nerve Antibodies  >677 publications with c-Kit and Nerve
 Spleen Antibodies  >642 publications with c-Kit and Spleen
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