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anti-MET antibody :: Mouse anti-Human c-Met Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245381
Immunohistochemistry (IHC)
Unit / Price
0.05 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

c-Met, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal (IgG2a) to Human c-Met

 Product Synonym Names    Anti-c-Met Antibody (Cytoplasmic Domain) IHC-plus; AUTS9; C-Met; HGF/SF receptor; HGFR; Met kinase; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; HGF receptor; RCCP2; Tyrosine-protein kinase Met; Human c-Met
 Product Gene Name   

anti-MET antibody

[Similar Products]
 Product Synonym Gene Name    c-Met [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 605074
 3D Structure    ModBase 3D Structure for P08581
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes c-Met.
 Purity/Purification    Purified
 Form/Format    PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
 Concentration    1.14 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide derived from cytoplasmic domain of human c-Met protein.
 Immunogen Type    Synthetic peptide
 Immunogen    c-Met antibody was raised against synthetic peptide derived from cytoplasmic domain of human c-Met protein.
 Antigen Modification    Cytoplasmic Domain
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
 Other Notes    Small volumes of anti-MET antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-MET antibody

   Met, an HGF Receptor/Met type protein kinase, is a cell-surface proto-oncogene that mediates the biological activities of hepatocyte growth factor. The protein is a disulfide-linked heterodimer comprised of two subunits: a 50 kD extracellular alpha subunit and a membrane-spanning 145 kD beta subunit that binds ligand. Met is an important regulator of cell proliferation and differentiation, organ regeneration, embryogenesis, and tumorogenesis.
 Product Categories/Family for anti-MET antibody    Family: Protein Kinase
Subfamily: HGF Receptor/MET
 Applications Tested/Suitable for anti-MET antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen)

 Application Notes for anti-MET antibody    IHC-Fr (1:50), IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-MET antibody    Anti-c-Met antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-MET antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for MET. It may not necessarily be applicable to this product.
 NCBI GI #    42741655
 NCBI GeneID    4233
 NCBI Accession #    NP_000236.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000245.2 [Other Products]
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 UniProt Primary Accession #    P08581 [Other Products]
 UniProt Secondary Accession #    O60366; Q12875; Q9UDX7; Q9UPL8; A1L467; B5A932; E7EQ94 [Other Products]
 UniProt Related Accession #    P08581 [Other Products]
 Molecular Weight    85,745 Da
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 NCBI Official Full Name    hepatocyte growth factor receptor isoform b
 NCBI Official Synonym Full Names    MET proto-oncogene, receptor tyrosine kinase
 NCBI Official Symbol    MET [Similar Products]
 NCBI Official Synonym Symbols   
HGFR; AUTS9; RCCP2; c-Met
[Similar Products]
 NCBI Protein Information    hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
 UniProt Protein Name    Hepatocyte growth factor receptor
 UniProt Synonym Protein Names   
HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
 Protein Family    C-methyltransferase
 UniProt Gene Name    MET [Similar Products]
 UniProt Synonym Gene Names    HGF receptor; SF receptor [Similar Products]
 UniProt Entry Name    MET_HUMAN
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 NCBI Summary for MET    The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MET    Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.

Protein type: Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Oncoprotein; TK group; Met family

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: cell surface; integral to plasma membrane; basal plasma membrane; integral to membrane; extracellular region; plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; protein phosphatase binding; hepatocyte growth factor receptor activity; ATP binding

Biological Process: axon guidance; skeletal muscle development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; myoblast proliferation; protein amino acid autophosphorylation; myotube differentiation; muscle cell migration; hepatocyte growth factor receptor signaling pathway; glucose homeostasis; liver development; signal transduction; cell proliferation; cell surface receptor linked signal transduction; positive chemotaxis; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; endothelial cell morphogenesis; brain development; placenta development

Disease: Hepatocellular Carcinoma; Renal Cell Carcinoma, Papillary, 1
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 Research Articles on MET    1. Results indicate that oridonin exerted anti-tumor growth on gastric cancer SNU-5 in vitro and in vivo by direct regulation of c-Met signaling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MET antibodyPathways associated with anti-MET antibody
 Reference Product  PubMed Publications
 HGF antibody  >2672 publications with MET and HGF
 CTNNB1 antibody  >218 publications with MET and CTNNB1
 UBC antibody  >157 publications with MET and UBC
 GRB2 antibody  >117 publications with MET and GRB2
 GAB1 antibody  >98 publications with MET and GAB1
 CBL antibody  >62 publications with MET and CBL
 PAX3 antibody  >42 publications with MET and PAX3
 PTPN11 antibody  >29 publications with MET and PTPN11
 PTPN1 antibody  >8 publications with MET and PTPN1
 PTPRJ antibody  >3 publications with MET and PTPRJ
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Diseases associated with anti-MET antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >8933 publications with MET and Cardiovascular Diseases
 Carcinoma Antibodies  >4653 publications with MET and Carcinoma
 Heart Diseases Antibodies  >4457 publications with MET and Heart Diseases
 Inflammation Antibodies  >2368 publications with MET and Inflammation
 Adenocarcinoma Antibodies  >2151 publications with MET and Adenocarcinoma
 Liver Diseases Antibodies  >2074 publications with MET and Liver Diseases
 Kidney Diseases Antibodies  >1800 publications with MET and Kidney Diseases
 Schizophrenia Antibodies  >1793 publications with MET and Schizophrenia
 Breast Neoplasms Antibodies  >1753 publications with MET and Breast Neoplasms
 Lung Neoplasms Antibodies  >1511 publications with MET and Lung Neoplasms
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