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anti-TNNT2 antibody :: anti-Human cTnT, Clone 1D7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135086 anti-TNNT2 antibody
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
1 mg  /  $1,495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cTnT, Clone 1D7 (TNNT2), Monoclonal Antibody

 Also Known As   

Anti Human cTnT, Clone 1D7

 Product Gene Name   

anti-TNNT2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (201328142..201346805, complement). Location: 1q32
 OMIM    115195
 3D Structure    ModBase 3D Structure for P45379
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 Clonality    Monoclonal
 Isotype    IgG3
 Clone Number    1D7-C11-D7
 Host    Host: Mouse; Source: Hybridoma cell culture
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen    Full length native protein (purified) (Human).
 Target Information    Recognises cTnT
 Target Molecular Weight    36000
 Buffer    0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
 Extinction Coefficient    1.36
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 5 years from delivery
 Other Notes    Small volumes of anti-TNNT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TNNT2 antibody

   Mouse monoclonal antibody to human Cardiac Troponin T (cTnT). IgG fraction purified by immobilized Protein A. Clone 1D7-C11-D7, isotype IgG13.
 Product Categories/Family for anti-TNNT2 antibody    Cardiac Troponin T (cTnT); Monoclonal Antibodies to Human Cardiac Troponin T
 Applications Tested/Suitable for anti-TNNT2 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TNNT2. It may not necessarily be applicable to this product.
 NCBI GI #    48255877
 NCBI GeneID    7139
 NCBI Accession #    NP_000355.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000364.3 [Other Products]
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 UniProt Primary Accession #    P45379 [Other Products]
 UniProt Secondary Accession #    O60214; Q99596; Q99597; Q9BUF6; Q9UM96; A2TDB9; A8K3K6 [Other Products]
 UniProt Related Accession #    P45379 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    troponin T, cardiac muscle isoform 1
 NCBI Official Synonym Full Names    troponin T type 2 (cardiac)
 NCBI Official Symbol    TNNT2 [Similar Products]
 NCBI Official Synonym Symbols   
CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6
[Similar Products]
 NCBI Protein Information    troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)
 UniProt Protein Name    Troponin T, cardiac muscle
 UniProt Synonym Protein Names   
Cardiac muscle troponin T
 Protein Family    Troponin
 UniProt Gene Name    TNNT2 [Similar Products]
 UniProt Synonym Gene Names    TnTc; cTnT [Similar Products]
 UniProt Entry Name    TNNT2_HUMAN
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 NCBI Summary for TNNT2    The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNNT2    TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding

Biological Process: positive regulation of ATPase activity; atrial cardiac muscle morphogenesis; regulation of muscle contraction; metabolic process; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2
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 Research Articles on TNNT2    1. For brain surgery cTnT was undetectable both before and after surgery.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNNT2 antibodyPathways associated with anti-TNNT2 antibody
 Reference Product  PubMed Publications
 TNNI3 antibody  >47 publications with TNNT2 and TNNI3
 TPM1 antibody  >31 publications with TNNT2 and TPM1
 TNNC1 antibody  >12 publications with TNNT2 and TNNC1
 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with anti-TNNT2 antibodyOrgans/Tissues associated with anti-TNNT2 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >121 publications with TNNT2 and Heart Diseases
 Cardiovascular Diseases Antibodies  >121 publications with TNNT2 and Cardiovascular Diseases
 Cardiomyopathies Antibodies  >97 publications with TNNT2 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic Antibodies  >92 publications with TNNT2 and Cardiomyopathy, Hypertrophic
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >45 publications with TNNT2 and Cardiomyopathy, Hypertrophic, Familial
 Cardiomyopathy, Dilated Antibodies  >37 publications with TNNT2 and Cardiomyopathy, Dilated
 Hypertrophy Antibodies  >34 publications with TNNT2 and Hypertrophy
 Cardiomyopathy, Familial Hypertrophic, 2 Antibodies  >28 publications with TNNT2 and Cardiomyopathy, Familial Hypertrophic, 2
 Heart Failure Antibodies  >25 publications with TNNT2 and Heart Failure
 Myocardial Ischemia Antibodies  >12 publications with TNNT2 and Myocardial Ischemia
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >89 publications with TNNT2 and Heart
 Muscle Antibodies  >79 publications with TNNT2 and Muscle
 Blood Antibodies  >36 publications with TNNT2 and Blood
 Embryonic Tissue Antibodies  >12 publications with TNNT2 and Embryonic Tissue
 Kidney Antibodies  >6 publications with TNNT2 and Kidney
 Lung Antibodies  >4 publications with TNNT2 and Lung
 Brain Antibodies  >4 publications with TNNT2 and Brain
 Connective Tissue Antibodies  >2 publications with TNNT2 and Connective Tissue
 Liver Antibodies  >2 publications with TNNT2 and Liver
 Eye Antibodies  >1 publications with TNNT2 and Eye
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