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anti-Cdk9 antibody :: Rabbit cdk9, p43 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS601199 anti-Cdk9 antibody
Unit / Price
0.02 mL  /  $385 +1 FREE 8GB USB
0.1 mL  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cdk9, p43, Monoclonal Antibody

 Also Known As   

cdk9, p43 (PITALRE, cdc Kinase Family, Cyclin-dependent Kinase 9)

 Product Synonym Names    Anti -cdk9, p43 (PITALRE, cdc Kinase Family, Cyclin-dependent Kinase 9)
 Product Gene Name   

anti-Cdk9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2R; NT_033778.3 (18523568..18525228, complement). Location: 58F2-58F3
 3D Structure    ModBase 3D Structure for O17432
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    8A9
 Host    Rabbit
 Species Reactivity    Bovine, Hamster, Human, Monkey, Mouse, Rat
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 Specificity    Detects endogenous levels of total CDK9 protein, both 42 kDa and 55 kDa isoforms.
 Purity/Purification    As reported
 Form/Format    Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol.
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 Immunogen    Synthetic peptide (KLH-coupled) corresponding to residues near the carboxy terminus of human CDK9.
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 Preparation and Storage    For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Cdk9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Cdk9 antibody

   P-TEFb is a general transcription factor that regulates transcription elongation through phosphorylation of the C-terminal tail domain (CTD) of RNA polymerase II (RNAP II). The P-TEFb complex composed of a catalytic subunit, CDK9, and its regulatory cyclin partner, which can be cyclin T1, T2a, T2b or K (reviewed in 1,2). P-TEFb is recruited by the HIV Tat protein to allow transcriptional elongation, and subsequent replication of the viral genome. Inhibition of P-TEFb function therefore has potential for HIV therapy. CDK9 exists as two isoforms, an abundant 42kD isoform, and a less abundant 55kD isoform, which contains an amino-terminal extension (3). The two forms likely have distinct purposes based on differential expression during lymphocyte activation (4,5) and on their localization within the nucleus (5). Cyclin dependent kinases (CDKs) are activated in part by cyclin binding and by phosphorylation of a conserved threonine in the T-loop domain. Phosphorylation of CDK9 at the T-loop Thr186 by an unidentified nuclear kinase may be important in P-TEFb activation (6) and regulation of HIV transcription (7). Acetylation of CDK9 at Lys44 affects its ability to phosphorylate the RNAPII CTD (8).
 Product Categories/Family for anti-Cdk9 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-Cdk9 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for anti-Cdk9 antibody    Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunofluorescence and Flow Cytometry
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:100
Immunohistochemistry (paraffin): 1:200
Immunohistochemistry (frozen): 1:200
Immunofluorescence: 1:25
Flow Cytometry: 1:200
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NCBI/Uniprot data below describe general gene information for Cdk9. It may not necessarily be applicable to this product.
 NCBI GI #    24658274
 NCBI GeneID    37586
 NCBI Accession #    NP_477226.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_057878.3 [Other Products]
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 UniProt Primary Accession #    O17432 [Other Products]
 UniProt Related Accession #    O17432 [Other Products]
 Molecular Weight    46,787 Da [Similar Products]
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 NCBI Official Full Name    Cyclin-dependent kinase 9
 NCBI Official Synonym Full Names    Cyclin-dependent kinase 9
 NCBI Official Symbol    Cdk9 [Similar Products]
 NCBI Official Synonym Symbols   
cdk9; CDK9; CG5179; DmelCG5179; P-TEF; P-TEFb; PTefb
[Similar Products]
 NCBI Protein Information    CG5179 gene product from transcript CG5179-RA; Cyclin-dependent kinase 9; CG5179-PA; Cdk9-PA; positive transcription elongation factor b, small subunit; Cyclin-dependent kinase9 2.7; p43 PITALRE
 UniProt Protein Name    Cyclin-dependent kinase 9
 Protein Family    Cyclin-dependent kinase
 UniProt Gene Name    Cdk9 [Similar Products]
 UniProt Entry Name    O17432_DROME
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 UniProt Comments for Cdk9    Sequence similarities: Belongs to the protein kinase superfamily. RuleBase RU000305V3
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 Research Articles on Cdk9    1. actin participates in transcription elongation by recruiting Cdk9,a catalytic subunit of P-TEFb, for phosphorylation of the Pol II C-terminal domain, and the actin-Cdk9 interaction promotes chromatin remodeling
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Cdk9 antibodyDiseases associated with anti-Cdk9 antibody
 Products by Pathway  Pathway Diagram
 Formation And Maturation Of MRNA Transcript Pathway antibodies  Formation And Maturation Of MRNA Transcript Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Polymerase II Pre-transcription Events Pathway antibodies  RNA Polymerase II Pre-transcription Events Pathway Diagram
 RNA Polymerase II Transcription Pathway antibodies  RNA Polymerase II Transcription Pathway Diagram
 RNA Polymerase II Transcription Elongation Pathway antibodies  RNA Polymerase II Transcription Elongation Pathway Diagram
 Transcription Pathway antibodies  Transcription Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >56 publications with Cdk9 and Neoplasms
 Leukemia Antibodies  >31 publications with Cdk9 and Leukemia
 HIV Infections Antibodies  >19 publications with Cdk9 and HIV Infections
 Cardiovascular Diseases Antibodies  >17 publications with Cdk9 and Cardiovascular Diseases
 Leukemia, Myeloid Antibodies  >13 publications with Cdk9 and Leukemia, Myeloid
 Necrosis Antibodies  >11 publications with Cdk9 and Necrosis
 Inflammation Antibodies  >8 publications with Cdk9 and Inflammation
 Vascular Diseases Antibodies  >8 publications with Cdk9 and Vascular Diseases
 Lymphoma Antibodies  >7 publications with Cdk9 and Lymphoma
 Lung Diseases Antibodies  >6 publications with Cdk9 and Lung Diseases
Organs/Tissues associated with anti-Cdk9 antibody
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >8 publications with Cdk9 and Embryonic Tissue
 Head Antibodies  >2 publications with Cdk9 and Head
 Testis Antibodies  >1 publications with Cdk9 and Testis
 Ovary Antibodies  >1 publications with Cdk9 and Ovary
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