Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow CLDN3 rightarrow Monoclonal CLDN3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • LILRB4 - CD85k - ILT3 Recombinant Protein
 • Syndecan-1 (SDC1) Antibody
 • NOD2 - CARD15 Antibody
 • Bu-1 Secondary Antibody
 • Dopamine (DA) ELISA Kit
 • 5-Methyl Cytosine Antibody
 • Cubilin (Cubn) ELISA Kit
 • leucocyte antigen B27, HLA-B27 ELISA Kit
 • lectin, galactoside-binding, soluble, 3 binding protein (LGA... ELISA Kit
 • T7 FITC (THVgp007) Antibody
 • resolvin D1 (RvD1) ELISA Kit
 • Shugoshin-like 1, SGOL1 ELISA Kit
 • Crystallin (CRYBA1) ELISA Kit
 • Guanine nucleotide-binding protein G (q) subunit alpha (Gnaq... Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-CLDN3 antibody :: claudin-3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS313135 anti-CLDN3 antibody
Unit / Price
1 mg  /  $730 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

claudin-3 (CLDN3), Monoclonal Antibody

 Also Known As   

MAb to Claudin-3 (aa 30-80)

 Product Synonym Names    Monoclonal Antibody to Human Claudin-3, amino acids 30-80.
 Product Gene Name   

anti-CLDN3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 7; NC_000007.13 (73183327..73184600, complement). Location: 7q11.23
 OMIM    602910
 3D Structure    ModBase 3D Structure for O15551
Section Bar
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    B1374M
 Host    Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.; Source: Ascites
Section Bar
 Specificity    claudin-3 (a.a. 30-80) (Human Claudin-3, amino acids 30-80.)
 Purity/Purification    > 90% pure (SDS-PAGE). Protein A Chromatography
 Form/Format    Purified, Liquid
Section Bar
 Preservative    0.1% Sodium Azide
 Immunogen    Recombinant fusion of Claudin-3 (a.a. 30-80) peptide and human thioredoxin.
 Affinity Constant    Not Determined
 Buffer    PBS, pH 7.4
Section Bar
 Preparation and Storage    Store at 2-8 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-CLDN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-CLDN3 antibody    Monoclonal Antibodies for Cancer Research
 Applications Tested/Suitable for anti-CLDN3 antibody   

ELISA (EIA)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for CLDN3. It may not necessarily be applicable to this product.
 NCBI GI #    4502875
 NCBI GeneID    1365
 NCBI Accession #    NP_001297.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001306.3 [Other Products]
Section Bar
 UniProt Primary Accession #    O15551 [Other Products]
 UniProt Related Accession #    O15551 [Other Products]
 Molecular Weight    23,319 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    claudin-3
 NCBI Official Synonym Full Names    claudin 3
 NCBI Official Symbol    CLDN3 [Similar Products]
 NCBI Official Synonym Symbols   
RVP1; HRVP1; C7orf1; CPE-R2; CPETR2
[Similar Products]
 NCBI Protein Information    claudin-3; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog; Clostridium perfringens enterotoxin receptor 2
 UniProt Protein Name    Claudin-3
 UniProt Synonym Protein Names   
Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog
 Protein Family    Claudin
 UniProt Gene Name    CLDN3 [Similar Products]
 UniProt Synonym Gene Names    C7orf1; CPETR2; CPE-R 2; CPE-receptor 2; hRVP1 [Similar Products]
 UniProt Entry Name    CLD3_HUMAN
Section Bar
 NCBI Summary for CLDN3    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for CLDN3    Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity

By similarity.

Subunit structure: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3

By similarity.

Subcellular location: Cell junction › tight junction

By similarity. Cell membrane; Multi-pass membrane protein

By similarity.

Involvement in disease: Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Sequence similarities: Belongs to the claudin family.
Table BarTOPTable Bar
 Research Articles on CLDN3    1. Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-CLDN3 antibodyPathways associated with anti-CLDN3 antibody
 Reference Product  PubMed Publications
 CLDN1 antibody  >10 publications with CLDN3 and CLDN1
 CLDN5 antibody  >3 publications with CLDN3 and CLDN5
 TJP1 antibody  >1 publications with CLDN3 and TJP1
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
Diseases associated with anti-CLDN3 antibodyOrgans/Tissues associated with anti-CLDN3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >28 publications with CLDN3 and Neoplasms
 Carcinoma Antibodies  >13 publications with CLDN3 and Carcinoma
 Ovarian Neoplasms Antibodies  >13 publications with CLDN3 and Ovarian Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with CLDN3 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >6 publications with CLDN3 and Adenocarcinoma
 Stomach Neoplasms Antibodies  >6 publications with CLDN3 and Stomach Neoplasms
 Breast Neoplasms Antibodies  >3 publications with CLDN3 and Breast Neoplasms
 Head and Neck Neoplasms Antibodies  >3 publications with CLDN3 and Head and Neck Neoplasms
 Infertility, Male Antibodies  >3 publications with CLDN3 and Infertility, Male
 Carcinoma, Squamous Cell Antibodies  >3 publications with CLDN3 and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >9 publications with CLDN3 and Ovary
 Stomach Antibodies  >7 publications with CLDN3 and Stomach
 Intestine Antibodies  >3 publications with CLDN3 and Intestine
 Liver Antibodies  >2 publications with CLDN3 and Liver
 Thyroid Antibodies  >2 publications with CLDN3 and Thyroid
 Uterus Antibodies  >2 publications with CLDN3 and Uterus
 Prostate Antibodies  >2 publications with CLDN3 and Prostate
 Mammary Gland Antibodies  >1 publications with CLDN3 and Mammary Gland
 Lung Antibodies  >1 publications with CLDN3 and Lung
 Kidney Antibodies  >1 publications with CLDN3 and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions