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anti-CCNA2 antibody :: Mouse cyclin A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS440093 anti-CCNA2 antibody
Unit / Price
0.1 mg  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

cyclin A (CCNA2), Monoclonal Antibody

 Also Known As   

cyclin A (E23.1) Antibody

 Product Gene Name   

anti-CCNA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123835
 3D Structure    ModBase 3D Structure for P20248
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Mouse, bovine, human
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 Specificity    Reacts with cyclin A of murine, bovine, and human origin
 Form/Format    100 ug/ml of mouse monoclonal IgG2a in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin.
 Concentration    0.100 mg/ml (lot specific)
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 Origin    Cyclin A (E67.1) is provided as mouse monoclonal IgG2a derived from a mouse immunized with bovine cyclin A. The epitope for this antibody has been mapped to a region containing the sequence LDYP. This epitope maps within amino acids 144-148 of human cyclin A2.Cyclin As that contain this epitope: Cow cyclin A2, human cyclin A2, hamster cyclin A2, mouse cylin A2.Cyclin As that do not contain this epitope: Chicken cyclin A2, human cyclin A1, mouse cyclin A1
 Immunogen    Bovine cyclin A
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 Preparation and Storage    Store this product at 4 degree C, do not freeze. The product is stable for one year from the date of shipment.
 Other Notes    Small volumes of anti-CCNA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CCNA2 antibody

   During each cell cycle cyclins undergo periodic accumulation and destruction. As key regulators of the cell cycle the cyclins control important transitions by activating Cdks (1,2). Cyclin A regulates at least two cdks, Cdc2 p34 and Cdk2, and is believed to be necessary for progression through S phase and is active during the G2-M transition (1&3,4). Cyclin B1 also associates with Cdc2 p34 and this complex is requisite for the G2-M progression. The Cyclin B1/Cdc2 p34 complex is known as MPF, M-phase kinase, maturation-promoting factor, or M-phase specific histone kinase, is widely accepted as the trigger of mitosis in all organisms (5-9).
 Applications Tested/Suitable for anti-CCNA2 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-CCNA2 antibody    Western blotting starting dilution: 1:100.
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NCBI/Uniprot data below describe general gene information for CCNA2. It may not necessarily be applicable to this product.
 NCBI GI #    4502613
 NCBI GeneID    890
 NCBI Accession #    NP_001228.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001237.3 [Other Products]
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 UniProt Primary Accession #    P20248 [Other Products]
 UniProt Secondary Accession #    Q2M3U6; Q4W5P4; Q6LER8; A8K7B6 [Other Products]
 UniProt Related Accession #    P20248 [Other Products]
 Molecular Weight    48,551 Da [Similar Products]
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 NCBI Official Full Name    cyclin-A2
 NCBI Official Synonym Full Names    cyclin A2
 NCBI Official Symbol    CCNA2 [Similar Products]
 NCBI Official Synonym Symbols   
CCN1; CCNA
[Similar Products]
 NCBI Protein Information    cyclin-A2
 UniProt Protein Name    Cyclin-A2
 Protein Family    Cyclin
 UniProt Gene Name    CCNA2 [Similar Products]
 UniProt Synonym Gene Names    CCN1; CCNA; Cyclin-A [Similar Products]
 UniProt Entry Name    CCNA2_HUMAN
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 NCBI Summary for CCNA2    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]
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 UniProt Comments for CCNA2    CCNA2: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: nucleoplasm; male pronucleus; cytoplasm; female pronucleus; nucleus

Molecular Function: protein binding; protein kinase binding

Biological Process: mitosis; organ regeneration; response to glucagon stimulus; positive regulation of transcription, DNA-dependent; response to estradiol stimulus; positive regulation of fibroblast proliferation; cell division; mitotic cell cycle G2/M transition DNA damage checkpoint; regulation of G2/M transition of mitotic cell cycle; Ras protein signal transduction; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle
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Product References and Citations for anti-CCNA2 antibody

   1. Bandara LR, Adamczewski JP, Zamanian M, Poon RY, Hunt T, Thangue NB. 1992. Cyclin A recruits p33cdk2 to the cellular transcription factor DRTF1. J Cell Sci Suppl 16: 77-85.2. Desdouets C, Sobczak-Thepot J, Murphy M, Brechot C. 1995. Cyclin A: Function and expression during cell proliferation. Prog Cell Cycle Res 1:115-123.3. Brechot C. 1993. Oncogenic activation of cyclin A. Curr Opin Genet Dev 3(1): 11-18.4. Goldstone S, Pavey S, Forrest A, Sinnamon J, Gabrielli B. 2001. Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene 20(8): 921-932.5. Liu D, Liao C, Wolgemuth DJ. 2000. A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. Dev Biol 224(2): 338-400.6. Hoffman I, Clarke PR, Marcotte MJ, Karsenti E, Draetta G. 1993. Phosphorylation and activation of human cdc25-C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J 12(1): 53-63. 7. Kishimoto T, Okumura E. 1997. In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2. Prog Cell Cycle Res 3:241-249.8. Baratte B, Meijer L, Galaktionov K, Beach D. 1992. Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase. Anticancer Res 12(3): 873-880.9. Thron CD. 1994. Theoretical dynamics of the cyclin B-MPF system: a possible role for p13suc1. Biosystems 32(2):97-109.
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 Research Articles on CCNA2    1. CCNA2 is a biomarker for the prognosis of ER+ breast cancer and monitoring of tamoxifen efficacy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CCNA2 antibodyPathways associated with anti-CCNA2 antibody
 Reference Product  PubMed Publications
 CDK2 antibody  >94 publications with CCNA2 and CDK2
 CDK1 antibody  >57 publications with CCNA2 and CDK1
 CDKN1A antibody  >56 publications with CCNA2 and CDKN1A
 CDKN1B antibody  >31 publications with CCNA2 and CDKN1B
 E2F1 antibody  >19 publications with CCNA2 and E2F1
 CDC20 antibody  >12 publications with CCNA2 and CDC20
 CDC6 antibody  >7 publications with CCNA2 and CDC6
 RB1 antibody  >5 publications with CCNA2 and RB1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cdc20:Phospho-APC/C Mediated Degradation Of Cyclin A Pathway antibodies  Cdc20:Phospho-APC/C Mediated Degradation Of Cyclin A Pathway Diagram
Diseases associated with anti-CCNA2 antibodyOrgans/Tissues associated with anti-CCNA2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >47 publications with CCNA2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >29 publications with CCNA2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >24 publications with CCNA2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >23 publications with CCNA2 and Neoplasms, Experimental
 Liver Diseases Antibodies  >22 publications with CCNA2 and Liver Diseases
 Disease Models, Animal Antibodies  >21 publications with CCNA2 and Disease Models, Animal
 Liver Neoplasms Antibodies  >20 publications with CCNA2 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >19 publications with CCNA2 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >15 publications with CCNA2 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >13 publications with CCNA2 and Prostatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >56 publications with CCNA2 and Liver
 Blood Antibodies  >53 publications with CCNA2 and Blood
 Lung Antibodies  >42 publications with CCNA2 and Lung
 Brain Antibodies  >29 publications with CCNA2 and Brain
 Muscle Antibodies  >28 publications with CCNA2 and Muscle
 Vascular Antibodies  >28 publications with CCNA2 and Vascular
 Bone Antibodies  >23 publications with CCNA2 and Bone
 Embryonic Tissue Antibodies  >22 publications with CCNA2 and Embryonic Tissue
 Testis Antibodies  >17 publications with CCNA2 and Testis
 Prostate Antibodies  >16 publications with CCNA2 and Prostate
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