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anti-Erbb4 antibody :: Mouse erbB4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS606828 anti-Erbb4 antibody
Unit / Price
0.1 mg  /  $615 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

erbB4, Monoclonal Antibody

 Also Known As   

erbB4 (c-erbB4, HER4)

 Product Synonym Names    Anti -erbB4 (c-erbB4, HER4)
 Product Gene Name   

anti-Erbb4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000067.5 (68086540..69154633, complement). Location: 1 C3; 1 35.1 cM
 3D Structure    ModBase 3D Structure for O88459
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    9H232
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human c-erB-4/Her 4 cytoplasmic domain of the protein (residues 1250-1264), a member of the EGF receptor (type 1) family involved in cell growth regulation. Expression or function may be altered in human cancers.
 Purity/Purification    Purified
Purified
 Form/Format    Supplied as a liquid in PBS, pH 7.6, 0.01% sodium azide.
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 Immunogen    Synthetic peptide sequence RSTLQHPDYLQEYST from the cytoplasmic domain of the protein, residues 1250-1264. Cellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Species sequence homology: mouse.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-Erbb4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Erbb4 antibody

   erbB4/HER4 is the fourth member of the human epidermal growth factor receptor (EGFR) family that is frequently overexpressed in a variety of aggressive epithelial carcinomas. Its extracellular domain is most similar to the orphan receptor HER3, whereas its cytoplasmic kinase domain exhibits 79% and 77% identity with EGFR and HER2, respectively. HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain and cerebellum.
 Product Categories/Family for anti-Erbb4 antibody    Antibodies; Abs to Oncoproteins
 Applications Tested/Suitable for anti-Erbb4 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-Erbb4 antibody    Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.
Dilution: Western Blot: 1:500-1:1000 detects erbB-4 on 10ug of A431 lysates.
Immunohistochemistry: formalin-fixed, paraffin-embedded sections.
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NCBI/Uniprot data below describe general gene information for Erbb4. It may not necessarily be applicable to this product.
 NCBI GI #    986917
 NCBI GeneID    13869
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 UniProt Primary Accession #    O88459 [Other Products]
 UniProt Related Accession #    O88459; Q61527 [Other Products]
 Molecular Weight    9,891 Da [Similar Products]
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 NCBI Official Full Name    erbB4
 NCBI Official Synonym Full Names    v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
 NCBI Official Symbol    Erbb4 [Similar Products]
 NCBI Official Synonym Symbols   
Her4; c-erbB-4
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-4; OTTMUSP00000030425; OTTMUSP00000030426; OTTMUSP00000030427; avian erythroblastosis oncogene B 4; proto-oncogene-like protein c-ErbB-4
 UniProt Protein Name    EGF-like growth factor receptor ErbB4 extracellular domain
 Protein Family    Receptor tyrosine-protein kinase
 UniProt Gene Name    Erbb4 [Similar Products]
 UniProt Entry Name    O88459_MOUSE
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 UniProt Comments for Erbb4    HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Kinase, protein; TK group; EGFR family

Cellular Component: mitochondrion; membrane; basolateral plasma membrane; cytoplasm; postsynaptic density; integral to membrane; plasma membrane; caveola; nucleus; receptor complex; lipid raft

Molecular Function: transferase activity; protein binding; protein homodimerization activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding; protein kinase activity

Biological Process: lactation; synapse maturation; peptidyl-tyrosine phosphorylation; apoptosis; positive regulation of transcription, DNA-dependent; heart development; protein amino acid autophosphorylation; multicellular organismal development; embryonic pattern specification; signal transduction; protein amino acid phosphorylation; olfactory bulb interneuron differentiation; regulation of cell migration; positive regulation of glucose import; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; nervous system development; cell migration; cell fate commitment; transcription, DNA-dependent; positive regulation of synaptic transmission, GABAergic; central nervous system morphogenesis; positive regulation of tyrosine phosphorylation of Stat5 protein; mitochondrial fragmentation during apoptosis; phosphorylation; surfactant homeostasis; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
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 Research Articles on Erbb4    1. signaling via the 2 alternative ErbB4 JM isoforms (JM-a CYT-2', JM-b CYT-2) was compared; fibroblasts expressing ErbB4 JM-a showed enhanced ErbB4 autophosphorylation, growth and survival; cells overexpressing ErbB4 JM-b underwent starvation-induced death
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Erbb4 antibodyDiseases associated with anti-Erbb4 antibody
 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >236 publications with Erbb4 and Neoplasms
 Breast Neoplasms Antibodies  >96 publications with Erbb4 and Breast Neoplasms
 Skin Diseases Antibodies  >93 publications with Erbb4 and Skin Diseases
 Carcinoma Antibodies  >86 publications with Erbb4 and Carcinoma
 Nervous System Diseases Antibodies  >49 publications with Erbb4 and Nervous System Diseases
 Heart Diseases Antibodies  >29 publications with Erbb4 and Heart Diseases
 Neoplasms, Experimental Antibodies  >29 publications with Erbb4 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >27 publications with Erbb4 and Adenocarcinoma
 Brain Diseases Antibodies  >26 publications with Erbb4 and Brain Diseases
 Lung Neoplasms Antibodies  >23 publications with Erbb4 and Lung Neoplasms
Organs/Tissues associated with anti-Erbb4 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >187 publications with Erbb4 and Brain
 Kidney Antibodies  >19 publications with Erbb4 and Kidney
 Mixed Antibodies  >5 publications with Erbb4 and Mixed
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