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anti-mTLR3 antibody :: Rat anti-Mouse mTLR3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS668027
Unit / Price
0.025 mg  /  $155 +1 FREE 8GB USB
0.1 mg  /  $250 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

mTLR3, Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to mTLR3 (ABM24E5)

 Product Synonym Names    Tlr3
 Product Gene Name   

anti-mTLR3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q99MB1
 Clonality    Monoclonal
 Isotype    Rat IgG2b, Kappa
 Clone Number    ABM24E5
 Host    Rat
 Species Reactivity    Mouse
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 Purity/Purification    Protein G Chromatography
 Form/Format    Purified (Liquid)
 Concentration    0.5 mg/ml, 200 Ál (lot specific)
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 Antigen    mTLR3
 Content    100 ug in 200ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
 Immunogen    A partial length recombinant mTLR3 protein (Amino acid sequence 180-385) was used as the immunogen for this antibody.
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 Preparation and Storage    Store the antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles.
 Other Notes    Small volumes of anti-mTLR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-mTLR3 antibody

   Mouse Toll-like receptor 3 (mTLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. It has seven exons. mTlr3 show high homology to hTLR3 in their predicted cDNA and protein sequences. The intracellular region of mTlr3 has remarkable homology with the same region of others mTlrs. mTlr3 mRNA is ubiquitously expressed in tissues, being expressed highest in spleen, kidney and lung. Its activation by the synthetic ligand polyinosine:polycytidylic acid (poly I:C) or by mRNA rapidly causes growth cone collapse and irreversibly inhibits neurite extension independent of NF-kappaB. The high levels of mTlr3 expression in Mz B cells perhaps contribute to their ability to clear antigen from the blood.
 Product Categories/Family for anti-mTLR3 antibody    TLR
 Applications Tested/Suitable for anti-mTLR3 antibody   

Western Blot (WB), FACS

 Application Notes for anti-mTLR3 antibody    Western blot analysis: 2-4 ug/ml; FACS analysis: 0.5 ug/10^6 cells
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 Western Blot (WB) of anti-mTLR3 antibody    Western Blot analysis of mTLR3. Anti- mTLR3 antibody (Clone: ABM24E5) was used at 2 ug/ml on mouse brain lysate.
anti-mTLR3 antibody Western Blot (WB) (WB) image
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 Flow Cytometry of anti-mTLR3 antibody    Intracellular flow analysis of mTLR3 in m Splenocytes using 0.5 tJg/1 0"6 cells of mTLR3 antibody (Clone: ABM24E5). Green represents isotype control; red represents anti-mTLR3 antibody. Goat anti-Rat FITe conjugate was used as secondary antibody .
anti-mTLR3 antibody Flow Cytometry (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for mTLR3. It may not necessarily be applicable to this product.
 NCBI GI #    31543872
 NCBI GeneID    142980
 NCBI Accession #    NP_569054.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_126166.4 [Other Products]
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 UniProt Primary Accession #    Q99MB1 [Other Products]
 UniProt Secondary Accession #    Q91ZM4 [Other Products]
 UniProt Related Accession #    Q99MB1 [Other Products]
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 NCBI Official Full Name    toll-like receptor 3
 NCBI Official Synonym Full Names    toll-like receptor 3
 NCBI Official Symbol    Tlr3 [Similar Products]
 NCBI Official Synonym Symbols   
AI957183
[Similar Products]
 NCBI Protein Information    toll-like receptor 3
 UniProt Protein Name    Toll-like receptor 3
 UniProt Synonym Protein Names   
CD_antigen: CD283
 UniProt Gene Name    Tlr3 [Similar Products]
 UniProt Entry Name    TLR3_MOUSE
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 UniProt Comments for mTLR3    TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: cell surface; membrane; endoplasmic reticulum; lysosomal membrane; cytoplasm; integral to membrane; intracellular; endosome

Molecular Function: identical protein binding; protein binding; transmembrane receptor activity; RNA binding; double-stranded RNA binding; receptor activity

Biological Process: positive regulation of interleukin-12 production; positive regulation of JNK cascade; microglial cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of interferon-alpha biosynthetic process; defense response; toll-like receptor 3 signaling pathway; signal transduction; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to exogenous dsRNA; positive regulation of interferon-beta production; positive regulation of interferon type I production; inflammatory response; defense response to virus; positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; response to virus; MyD88-independent toll-like receptor signaling pathway; response to dsRNA; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine biosynthetic process; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; I-kappaB phosphorylation; microglial cell activation during immune response; positive regulation of interferon-gamma biosynthetic process; positive regulation of inflammatory response
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 Research Articles on mTLR3    1. A role for APPL1 in TLR3/4-dependent TBK1 and IKKepsilon activation in macrophages.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-mTLR3 antibodyPathways associated with anti-mTLR3 antibody
 Reference Product  PubMed Publications
 Myd88 antibody  >379 publications with mTLR3 and Myd88
 Ddx58 antibody  >106 publications with mTLR3 and Ddx58
 Ticam1 antibody  >96 publications with mTLR3 and Ticam1
 Ifih1 antibody  >88 publications with mTLR3 and Ifih1
 Stat1 antibody  >70 publications with mTLR3 and Stat1
 Traf6 antibody  >42 publications with mTLR3 and Traf6
 Unc93b1 antibody  >40 publications with mTLR3 and Unc93b1
 Tab2 antibody  >4 publications with mTLR3 and Tab2
 Nfkb1 antibody  >2 publications with mTLR3 and Nfkb1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Caspase Activation Via Extrinsic Apoptotic Signalig Pathway antibodies  Caspase Activation Via Extrinsic Apoptotic Signalig Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-mTLR3 antibodyOrgans/Tissues associated with anti-mTLR3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >634 publications with mTLR3 and Inflammation
 Necrosis Antibodies  >385 publications with mTLR3 and Necrosis
 Lung Diseases Antibodies  >129 publications with mTLR3 and Lung Diseases
 Asthma Antibodies  >90 publications with mTLR3 and Asthma
 Kidney Diseases Antibodies  >66 publications with mTLR3 and Kidney Diseases
 Respiratory Hypersensitivity Antibodies  >40 publications with mTLR3 and Respiratory Hypersensitivity
 Adenocarcinoma Antibodies  >40 publications with mTLR3 and Adenocarcinoma
 Heart Diseases Antibodies  >38 publications with mTLR3 and Heart Diseases
 Encephalitis, Herpes Simplex Antibodies  >37 publications with mTLR3 and Encephalitis, Herpes Simplex
 Carcinoma, Hepatocellular Antibodies  >36 publications with mTLR3 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >235 publications with mTLR3 and Lung
 Brain Antibodies  >133 publications with mTLR3 and Brain
 Spleen Antibodies  >122 publications with mTLR3 and Spleen
 Skin Antibodies  >100 publications with mTLR3 and Skin
 Eye Antibodies  >70 publications with mTLR3 and Eye
 Embryonic Tissue Antibodies  >33 publications with mTLR3 and Embryonic Tissue
 Oviduct Antibodies  >11 publications with mTLR3 and Oviduct
 Dorsal Root Ganglion Antibodies  >7 publications with mTLR3 and Dorsal Root Ganglion
 Ovary Antibodies  >6 publications with mTLR3 and Ovary
 Bladder Antibodies  >4 publications with mTLR3 and Bladder
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