AAB60456.1
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
p21
NCBI Official Synonym Full Names
cyclin-dependent kinase inhibitor 1A (P21)
NCBI Official Synonym Symbols
P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP20; Cdkn1; p21WAF; p21Cip1 [Similar Products]
NCBI Protein Information
cyclin-dependent kinase inhibitor 1; p21<WAF1/CIP1>; CDK-interacting protein 1; melanoma differentiation-associated protein
UniProt Protein Name
Cyclin-dependent kinase inhibitor 1
UniProt Synonym Protein Names
CDK-interacting protein 1; Melanoma differentiation-associated protein; p21
UniProt Synonym Gene Names
UniProt Entry Name
CDN1A_MOUSE
UniProt Comments for Cdkn1a
p21Cip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. Its expression is tightly controlled by p53, through which this protein mediates the p53-dependent cell cycle arrest at G1 phase.
Protein type: Cell cycle regulation; Inhibitor
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus; cytosol
Molecular Function: cyclin-dependent protein kinase inhibitor activity; cyclin binding; protein binding; cyclin-dependent protein kinase activating kinase activity; protein kinase inhibitor activity; ubiquitin protein ligase binding; metal ion binding; protein complex binding
Biological Process: regulation of cell cycle; regulation of mitotic cell cycle; negative regulation of cyclin-dependent protein kinase activity; cell cycle; protein amino acid phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; negative regulation of cell proliferation; positive regulation of programmed cell death; positive regulation of fibroblast proliferation; positive regulation of protein kinase activity; cellular response to extracellular stimulus; positive regulation of B cell proliferation; negative regulation of phosphorylation; regulation of protein import into nucleus, translocation; regulation of cyclin-dependent protein kinase activity; negative regulation of cell growth; cell cycle arrest; G2/M transition of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to DNA damage stimulus; response to UV; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on Cdkn1a
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Pathways associated with anti-Cdkn1a antibody
Diseases associated with anti-Cdkn1a antibody
Organs/Tissues associated with anti-Cdkn1a antibody
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