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anti-Cdkn1a antibody :: Mouse p21,WAF1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603733 anti-Cdkn1a antibody
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p21,WAF1 (Cdkn1a), Monoclonal Antibody

 Also Known As   

p21,WAF1 (Cip1, Sdi1, Pic1,Wild-type p53-activated Fragment, Tumor Suppressor Protein)

 Product Synonym Names    Anti -p21,WAF1 (Cip1, Sdi1, Pic1,Wild-type p53-activated Fragment, Tumor Suppressor Protein)
 Product Gene Name   

anti-Cdkn1a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000083.6 (29090986..29100722). Location: 17 A3.3; 17 15.12 cM
 3D Structure    ModBase 3D Structure for P39689
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    0.N.489
 Host    Mouse
 Species Reactivity    Bovine, Human, Mouse, Rat
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 Specificity    Recognizes Human, bovine, Mouse and Rat p21WAF1/Cip1/Sdi1/Pic1 tumor suppressor protein.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in 10mM PBS, pH 7.4, with 0.2% BSA and 15mM sodium azide. Also supplied without BSA and sodium azide. See P1000-55X.
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 Immunogen    Full length human recombinant p21 protein.
 Cellular Localization    Nuclear
 Hybridoma    Produced by fusion between RBF/DnJ splenocytes and mouse myeloma NS1 cells.
 Positive Control    Ls174T or Raji cells. Colon CA.
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 Preparation and Storage    -20 degree C
 Other Notes    Small volumes of anti-Cdkn1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Cdkn1a antibody

   Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. Meanwhile, the p21WAF1 protein also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Evidently, inactivation of p53 disrupts the p53-dependent expression of p21WAF1. p21WAF1is a tumor suppressor involved in the pathogenesis of a variety of malignancies.
 Product Categories/Family for anti-Cdkn1a antibody    Antibodies; Abs to Cancer Markers
 Applications Tested/Suitable for anti-Cdkn1a antibody   

Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

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NCBI/Uniprot data below describe general gene information for Cdkn1a. It may not necessarily be applicable to this product.
 NCBI GI #    595303
 NCBI GeneID    12575
 NCBI Accession #    AAB60456.1 [Other Products]
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 UniProt Primary Accession #    P39689 [Other Products]
 UniProt Related Accession #    P39689 [Other Products]
 Molecular Weight    17,785 Da [Similar Products]
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 NCBI Official Full Name    p21
 NCBI Official Synonym Full Names    cyclin-dependent kinase inhibitor 1A (P21)
 NCBI Official Symbol    Cdkn1a [Similar Products]
 NCBI Official Synonym Symbols   
P21; CDKI; CIP1; SDI1; Waf1; mda6; CAP20; Cdkn1; p21WAF; p21Cip1
[Similar Products]
 NCBI Protein Information    cyclin-dependent kinase inhibitor 1; p21<WAF1/CIP1>; CDK-interacting protein 1; melanoma differentiation-associated protein
 UniProt Protein Name    Cyclin-dependent kinase inhibitor 1
 UniProt Synonym Protein Names   
CDK-interacting protein 1; Melanoma differentiation-associated protein; p21
 UniProt Gene Name    Cdkn1a [Similar Products]
 UniProt Synonym Gene Names    Cip1; Waf1 [Similar Products]
 UniProt Entry Name    CDN1A_MOUSE
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 UniProt Comments for Cdkn1a    p21Cip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. Its expression is tightly controlled by p53, through which this protein mediates the p53-dependent cell cycle arrest at G1 phase.

Protein type: Inhibitor; Cell cycle regulation

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; cytosol; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; cyclin binding; cyclin-dependent protein kinase activating kinase activity; protein kinase inhibitor activity; ubiquitin protein ligase binding; metal ion binding; protein complex binding

Biological Process: regulation of cell cycle; regulation of mitotic cell cycle; negative regulation of cyclin-dependent protein kinase activity; cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein amino acid phosphorylation; negative regulation of cell proliferation; positive regulation of programmed cell death; positive regulation of fibroblast proliferation; positive regulation of protein kinase activity; positive regulation of B cell proliferation; cellular response to extracellular stimulus; negative regulation of phosphorylation; regulation of protein import into nucleus, translocation; negative regulation of cell growth; regulation of cyclin-dependent protein kinase activity; cell cycle arrest; G2/M transition of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to DNA damage stimulus; G1/S transition of mitotic cell cycle; negative regulation of apoptosis; response to UV
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 Research Articles on Cdkn1a    1. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc/Miz1 complexes that mediates p21 and p15 down-regulation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Cdkn1a antibodyDiseases associated with anti-Cdkn1a antibody
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5500 publications with Cdkn1a and Neoplasms
 Gastrointestinal Diseases Antibodies  >899 publications with Cdkn1a and Gastrointestinal Diseases
 Adenocarcinoma Antibodies  >895 publications with Cdkn1a and Adenocarcinoma
 Breast Neoplasms Antibodies  >789 publications with Cdkn1a and Breast Neoplasms
 Intestinal Neoplasms Antibodies  >623 publications with Cdkn1a and Intestinal Neoplasms
 Neoplasms, Experimental Antibodies  >503 publications with Cdkn1a and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >410 publications with Cdkn1a and Lung Neoplasms
 Liver Diseases Antibodies  >382 publications with Cdkn1a and Liver Diseases
 Colonic Neoplasms Antibodies  >364 publications with Cdkn1a and Colonic Neoplasms
 Prostatic Neoplasms Antibodies  >362 publications with Cdkn1a and Prostatic Neoplasms
Organs/Tissues associated with anti-Cdkn1a antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >841 publications with Cdkn1a and Blood
 Lung Antibodies  >694 publications with Cdkn1a and Lung
 Muscle Antibodies  >662 publications with Cdkn1a and Muscle
 Liver Antibodies  >585 publications with Cdkn1a and Liver
 Skin Antibodies  >378 publications with Cdkn1a and Skin
 Kidney Antibodies  >315 publications with Cdkn1a and Kidney
 Brain Antibodies  >314 publications with Cdkn1a and Brain
 Stomach Antibodies  >218 publications with Cdkn1a and Stomach
 Intestine Antibodies  >184 publications with Cdkn1a and Intestine
 Embryonic Tissue Antibodies  >184 publications with Cdkn1a and Embryonic Tissue
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