Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow p53 rightarrow Monoclonal p53  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • PPM1D Antibody
 • Pectinase (PG2) Enzyme
 • Hepatocyte Growth Factor (HGF) Antibody
 • CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody
 • RBC, IgG Fraction Antibody
 • Apelin Receptor (APLNR) ELISA Kit
 • Procollagen III N-Terminal Propeptide (PIIINP) Antibody
 • BAFF Receptor (TNFRSF13C) Antibody
 • IKK alpha (CHUK) Antibody
 • fibroblast growth factor 8 (androgen-induced) (FGF8) ELISA Kit
 • 5-Phosphoribosyl 1-Pyrophosphate (PRPP) ELISA Kit
 • TLR2 Antibody
 • Uncharacterized protein C12orf28 (C12orf28) Recombinant Protein
 • Histone H3.3 Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-p53 antibody :: Mouse p53 (a.a. 371-380) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS395175 anti-p53 antibody
Unit / Price
0.1 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p53 (a.a. 371-380), Monoclonal Antibody

★Popular Item★
 Also Known As   

p53 (a.a. 371-380)

 Product Gene Name   

anti-p53 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 10; NC_000076.6 (61715263..61739260). Location: 10 B4; 10
 3D Structure    ModBase 3D Structure for Q8BUE4
Section Bar
 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    Pab122
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Monkey, Hamster
Section Bar
 Purity/Purification    Protein A/G Chromatography
 Form/Format    Provided as solution in phosphate buffered saline with 0.08% sodium azide
Section Bar
 Immunogen    Hybridoma produced by the fusion of splenocytes from immunized with full length mouse p53 protein and mouse myeloma cells.
 Positive Control    Breast or colon carcinoma
 Comment    THis antibody can be used for Western Blotting (5-10ug/ml, immunohistochemistry on frozen and formalin/paraffain embedded tissues (1-2ug/ml) and immunoprecipitation (2ug/mg of protein lysate). Optimal concentration should be evaluated by serial dilutions.
Section Bar
 Preparation and Storage    Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Shipping: Ship at ambient temperature, freeze upton arrival.
Stability: Products are stable for one year from puchase when stored properly.
 Other Notes    Small volumes of anti-p53 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-p53 antibody

   p53 is a 53 kDa transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others.
 Product Categories/Family for anti-p53 antibody    Monoclonal Antibody; p53, and Related/Induced Proteins
 Applications Tested/Suitable for anti-p53 antibody   

Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for p53. It may not necessarily be applicable to this product.
 NCBI GI #    85861162
 NCBI GeneID    71361
 NCBI Accession #    NP_001034283.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001039194.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q8BUE4 [Other Products]
 UniProt Secondary Accession #    Q8CHZ2 [Other Products]
 UniProt Related Accession #    Q8BUE4 [Other Products]
 Molecular Weight    40,635 Da
Table BarTOPTable Bar
 NCBI Official Full Name    apoptosis-inducing factor 2 isoform 2
 NCBI Official Synonym Full Names    apoptosis-inducing factor, mitochondrion-associated 2
 NCBI Official Symbol    Aifm2 [Similar Products]
 NCBI Official Synonym Symbols   
Amid; PRG3; 5430437E11Rik; D730001I10Rik
[Similar Products]
 NCBI Protein Information    apoptosis-inducing factor 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor homologous mitochondrion-associated inducer of death
 UniProt Protein Name    Apoptosis-inducing factor 2
 UniProt Synonym Protein Names   
Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death
 UniProt Gene Name    Aifm2 [Similar Products]
 UniProt Synonym Gene Names    Amid [Similar Products]
 UniProt Entry Name    AIFM2_MOUSE
Section Bar
 UniProt Comments for p53    Function: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death

By similarity. May contribute to genotoxin-induced growth arrest.

Cofactor: FAD. Binds 6-hydroxy-FAD non-covalently

By similarity.

Subcellular location: Cytoplasm. Mitochondrion outer membrane

By similarity.

Tissue specificity: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in liver, testis, and kidney, and expressed at lower levels in pancreas, spleen, brain and lung. Ref.4

Induction: Expression is up-regulated in mouse embryonic fibroblasts by genotoxic reagents 5-fluorouracil and etoposide. Ref.4

Sequence similarities: Belongs to the FAD-dependent oxidoreductase family.

Sequence caution: Isoform 2: The sequence AAH38129.1 differs from that shown. Reason: erroneous termination (Translated as Trp in position: 339:Stop->W)
Table BarTOPTable Bar
 Research Articles on p53    1. Results demonstrate nuclear AIF translocation only in PARG-null TS cells, which demonstrates the presence of AIF-mediated cell death.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-p53 antibodyDiseases associated with anti-p53 antibody
 Reference Product  PubMed Publications
 Trp53 antibody  >3 publications with p53 and Trp53
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with p53 and Neoplasms
 Adenocarcinoma Antibodies  >2 publications with p53 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with p53 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >1 publications with p53 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with p53 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >1 publications with p53 and Neoplasms, Experimental
Organs/Tissues associated with anti-p53 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with p53 and Lung
 Kidney Antibodies  >1 publications with p53 and Kidney
 Brain Antibodies  >1 publications with p53 and Brain
 Embryonic Tissue Antibodies  >1 publications with p53 and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions