NP_001034283.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,635 Da
NCBI Official Full Name
apoptosis-inducing factor 2 isoform 2
NCBI Official Synonym Full Names
apoptosis-inducing factor, mitochondrion-associated 2
NCBI Official Synonym Symbols
Amid; PRG3; 5430437E11Rik; D730001I10Rik [Similar Products]
NCBI Protein Information
apoptosis-inducing factor 2; apoptosis-inducing factor-like mitchondrion-associated inducer of death; apoptosis-inducing factor-like mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor homologous mitochondrion-associated inducer of death
UniProt Protein Name
Apoptosis-inducing factor 2
UniProt Synonym Protein Names
Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death
UniProt Synonym Gene Names
UniProt Entry Name
AIFM2_MOUSE
UniProt Comments for p53
Function: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death
By similarity. May contribute to genotoxin-induced growth arrest.
Cofactor: FAD. Binds 6-hydroxy-FAD non-covalently
By similarity.
Subcellular location: Cytoplasm. Mitochondrion outer membrane
By similarity.
Tissue specificity: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in liver, testis, and kidney, and expressed at lower levels in pancreas, spleen, brain and lung. Ref.4
Induction: Expression is up-regulated in mouse embryonic fibroblasts by genotoxic reagents 5-fluorouracil and etoposide. Ref.4
Sequence similarities: Belongs to the FAD-dependent oxidoreductase family.
Sequence caution: Isoform 2: The sequence AAH38129.1 differs from that shown. Reason: erroneous termination (Translated as Trp in position: 339:Stop->W)
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Products associated with anti-p53 antibody
Diseases associated with anti-p53 antibody
Organs/Tissues associated with anti-p53 antibody
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