View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Add To Compare List anti-sAPP alpha antibody :: Mouse anti-Mouse, Rat sAPP alpha Monoclonal Antibody Catalog # MBS533522 Unit / Price DISCONTINUEDClick here to view our similar product(s) OR click here to contact our technical support team for suitable replacement. Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name sAPP alpha, Monoclonal Antibody Popular Item Full Product Name sAPP alpha antibody Product Synonym Names Monoclonal sAPP alpha; Anti-sAPP; soluble APP alpha; Mutant APP alpha; soluble amyloid precursor protein alpha; Mutant C-terminus APP alpha; sAPP alpha; Anti sAPP Product Gene Name anti-sAPP alpha antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Clonality Monoclonal Isotype IgG2b Clone Number 2B3 Host Mouse Species Reactivity Mouse, Rat Specificity Human Purity/Purification sAPP alpha antibody was affinity purified with antigen peptide Form/Format Lyophilized product from 1% BSA in PBS, pH 7.4 containing 0.05% NaN3, reconstitute with 1 ml deionised water Source Note Supernatant Biological Significance Amyloid precursor protein (APP) is precursor protein of Amyloid beta which is major constituent of senile plaque in Alzheimer?s disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway.The non-amyloidogenic pathway is mediated by alpha and gamma-secretases and gives rise to a large fragment known as soluble APPalpha (sAPPalpha) and a small 3 kDa peptide known as p3. On the other hand, the Amyloidogenic pathway is mediated by beta and gamma secretases and yields soluble APPbeta (sAPPbeta) and Amyloid beta. APP is expressed by many tissues within an organism. It is supposed that the function of APP in the neuronal system is different from that in other organs. Immunogen Amyloid precursor protein antibody was raised in mouse using a synthetic peptide of the Cterminal part of human sAPPa (DAEFRHDSGYEVHHQK) as the immunogen Preparation and Storage Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at 20 degree C for long term storage. Avoid repeated freeze/thaw cycles. Other Notes Small volumes of anti-sAPP alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-sAPP alpha antibody Human sAPP alpha antibody Product Categories/Family for anti-sAPP alpha antibody Neuroscience Applications Tested/Suitable for anti-sAPP alpha antibody Western Blot (WB), Immunoprecipitation (IP) Application Notes for anti-sAPP alpha antibody IP: 3 ug/testWB: 25 ug/ml TOP Product References and Citations for anti-sAPP alpha antibody Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction. Luca Rosario La Rosa, Lorena Perrone, Morten Schallburg Nielsen, Pietro Calissano, Olav Michael Andersen, and Carmela Matrone (2015) TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP