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anti-PLAU antibody :: anti-Human uPA, clone 3G65 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135046 anti-PLAU antibody
Unit / Price
1 mg  /  $475 +1 FREE 8GB USB
10 mg  /  $3,565 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

uPA, clone 3G65 (PLAU), Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal to human uPA, clone 3G65

 Product Gene Name   

anti-PLAU antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (75670862..75677259). Location: 10q22.2
 OMIM    191840
 3D Structure    ModBase 3D Structure for P00749
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    724-3G6-5
 Host    Host: Mouse; Source: Hybridoma cell culture
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    1.79 mg/ml (lot specific)
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 Aliquot    1 x 1.0mg
 Volume    0.559ml
 Immunogen    Recombinant full length wild-type human protein (Glycosylated).
 Target Information    Recognises the beta chain of Urokinase (uPA)
 Target Molecular Weight    54000
 Buffer    0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
 Extinction Coefficient    1.36
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 5 years from delivery
 Other Notes    Small volumes of anti-PLAU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLAU antibody

   Capture monoclonal antibody directed to the C-terminal beta (heavy) chain region of human uPA, which includes the active site. IgG fraction purified by immobilized Protein G. Isotype IgG.
 Product Categories/Family for anti-PLAU antibody    Urokinase (uPA); Monoclonal Antibodies to Human uPA
 Applications Tested/Suitable for anti-PLAU antibody   

ELISA (EIA), Capture, Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PLAU. It may not necessarily be applicable to this product.
 NCBI GI #    222537759
 NCBI GeneID    5328
 NCBI Accession #    NP_001138503.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145031.1 [Other Products]
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 UniProt Primary Accession #    P00749 [Other Products]
 UniProt Secondary Accession #    Q15844; Q16618; Q53XS3; Q5SWW9; Q969W6; B4DPZ2 [Other Products]
 UniProt Related Accession #    P00749 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    urokinase-type plasminogen activator isoform 2
 NCBI Official Synonym Full Names    plasminogen activator, urokinase
 NCBI Official Symbol    PLAU [Similar Products]
 NCBI Official Synonym Symbols   
ATF; QPD; UPA; URK; u-PA; BDPLT5
[Similar Products]
 NCBI Protein Information    urokinase-type plasminogen activator; U-plasminogen activator; plasminogen activator, urinary
 UniProt Protein Name    Urokinase-type plasminogen activator
 Protein Family    Urokinase-type plasminogen activator
 UniProt Gene Name    PLAU [Similar Products]
 UniProt Synonym Gene Names    U-plasminogen activator; uPA [Similar Products]
 UniProt Entry Name    UROK_HUMAN
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 NCBI Summary for PLAU    This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
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 UniProt Comments for PLAU    uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.21.73; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: extracellular space; cell surface; focal adhesion; extracellular region; plasma membrane

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: regulation of cell adhesion mediated by integrin; fibrinolysis; regulation of smooth muscle cell migration; smooth muscle cell migration; response to hypoxia; regulation of receptor activity; chemotaxis; signal transduction; proteolysis; blood coagulation; regulation of cell proliferation

Disease: Quebec Platelet Disorder; Alzheimer Disease
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 Research Articles on PLAU    1. SphK1 promoting the secretion of MMP-2/9 and uPA via activation of ERK1/2 and suppression of p38 MAPK pathways maybe the molecular mechanisms for its regulation of the malignant behavior of colon cancer cell.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLAU antibodyPathways associated with anti-PLAU antibody
 Reference Product  PubMed Publications
 PLAUR antibody  >14 publications with PLAU and PLAUR
 SERPINE1 antibody  >10 publications with PLAU and SERPINE1
 SERPINB2 antibody  >6 publications with PLAU and SERPINB2
 PLAT antibody  >6 publications with PLAU and PLAT
 CTSB antibody  >3 publications with PLAU and CTSB
 PLG antibody  >1 publications with PLAU and PLG
 HGF antibody  >1 publications with PLAU and HGF
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
Diseases associated with anti-PLAU antibodyOrgans/Tissues associated with anti-PLAU antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >15 publications with PLAU and Adenocarcinoma
 Alzheimer Disease Antibodies  >14 publications with PLAU and Alzheimer Disease
 Inflammation Antibodies  >13 publications with PLAU and Inflammation
 Neoplasm Invasiveness Antibodies  >9 publications with PLAU and Neoplasm Invasiveness
 Prostatic Neoplasms Antibodies  >8 publications with PLAU and Prostatic Neoplasms
 Neoplasm Metastasis Antibodies  >7 publications with PLAU and Neoplasm Metastasis
 Stomach Neoplasms Antibodies  >5 publications with PLAU and Stomach Neoplasms
 Pancreatic Neoplasms Antibodies  >4 publications with PLAU and Pancreatic Neoplasms
 Hemorrhage Antibodies  >3 publications with PLAU and Hemorrhage
 Necrosis Antibodies  >2 publications with PLAU and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with PLAU and Blood
 Lung Antibodies  >12 publications with PLAU and Lung
 Brain Antibodies  >10 publications with PLAU and Brain
 Bone Antibodies  >9 publications with PLAU and Bone
 Prostate Antibodies  >9 publications with PLAU and Prostate
 Vascular Antibodies  >7 publications with PLAU and Vascular
 Stomach Antibodies  >6 publications with PLAU and Stomach
 Skin Antibodies  >6 publications with PLAU and Skin
 Liver Antibodies  >6 publications with PLAU and Liver
 Placenta Antibodies  >6 publications with PLAU and Placenta
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