P04198
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
NCBI Official Synonym Full Names
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
NCBI Official Synonym Symbols
NMYC; ODED; MODED; N-myc; bHLHe37; MYCN [Similar Products]
NCBI Protein Information
N-myc proto-oncogene protein; pp65/67; oncogene NMYC; neuroblastoma MYC oncogene; class E basic helix-loop-helix protein 37; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
UniProt Protein Name
N-myc proto-oncogene protein
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 37
UniProt Synonym Gene Names
UniProt Entry Name
MYCN_HUMAN
NCBI Summary for MYCN
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. [provided by RefSeq]
UniProt Comments for MYCN
N-Myc: a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors.
Protein type: Transcription factor; Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 2p24.3
Cellular Component: chromatin; nucleus
Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; positive regulation of mesenchymal cell proliferation; negative regulation of astrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; embryonic skeletal morphogenesis; cartilage condensation; lung development
Disease: Feingold Syndrome 1; Tracheoesophageal Fistula With Or Without Esophageal Atresia
Research Articles on MYCN
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Products associated with anti-MYCN antibody
Pathways associated with anti-MYCN antibody
Diseases associated with anti-MYCN antibody
Organs/Tissues associated with anti-MYCN antibody
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