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anti-VTN antibody :: anti-Human vitronectin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135003 anti-VTN antibody
Unit / Price
1 mg  /  $500 +1 FREE 8GB USB
10 mg  /  $3,545 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

vitronectin (VTN), Monoclonal Antibody

 Also Known As   

Mouse monoclonal to human vitronectin

 Product Gene Name   

anti-VTN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (26694298..26697373, complement). Location: 17q11
 OMIM    193190
 3D Structure    ModBase 3D Structure for P04004
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    615-4A1-32
 Host    Host: Mouse; Source: Mouse ascites
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    6.3 mg/ml
Aliquot: 1 x 1.0mg
Volume: 0.158 ml (lot specific)
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 Immunogen    Full length native protein (purified) (Human).
 Target Information    Recognises Vitronectin
 Target Molecular Weight    75,000
 Buffer    0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
 Extinction Coefficient    1.36
 Antigen    Full length native protein (purified) (Human).
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 5 years from delivery
 Other Notes    Small volumes of anti-VTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-VTN antibody

   WB: Reduced and non-reduced monomeric vitronectin
 Product Categories/Family for anti-VTN antibody    Vitronectin; Monoclonal Antibodies to Human Vitronectin
 Applications Tested/Suitable for anti-VTN antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for VTN. It may not necessarily be applicable to this product.
 NCBI GI #    88853069
 NCBI GeneID    7448
 NCBI Accession #    NP_000629.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000638.3 [Other Products]
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 UniProt Primary Accession #    P04004 [Other Products]
 UniProt Secondary Accession #    P01141; Q9BSH7; B2R7G0 [Other Products]
 UniProt Related Accession #    P04004 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    vitronectin
 NCBI Official Synonym Full Names    vitronectin
 NCBI Official Symbol    VTN [Similar Products]
 NCBI Official Synonym Symbols   
VN; V75; VNT
[Similar Products]
 NCBI Protein Information    vitronectin; epibolin; S-protein; somatomedin B; complement S-protein; serum spreading factor; serum-spreading factor
 UniProt Protein Name    Vitronectin
 UniProt Synonym Protein Names   
S-protein; Serum-spreading factor; V75
 Protein Family    Vitronectin
 UniProt Gene Name    VTN [Similar Products]
 UniProt Synonym Gene Names    VN [Similar Products]
 UniProt Entry Name    VTNC_HUMAN
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 NCBI Summary for VTN    The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VTN    VTN: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

Protein type: Secreted, signal peptide; Cell adhesion; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 17q11

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: integrin binding; heparin binding; protein binding; extracellular matrix binding; scavenger receptor activity; polysaccharide binding

Biological Process: receptor-mediated endocytosis; extracellular matrix organization and biogenesis; positive regulation of protein binding; cell-matrix adhesion; negative regulation of blood coagulation; positive regulation of smooth muscle cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of receptor-mediated endocytosis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of complement activation; cell adhesion mediated by integrin; innate immune response; immune response; cell adhesion
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 Research Articles on VTN    1. Importance of vitronectin and its interaction with the urokinase receptor in tumor growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VTN antibodyPathways associated with anti-VTN antibody
 Reference Product  PubMed Publications
 SERPINE1 antibody  >5 publications with VTN and SERPINE1
 PLAUR antibody  >3 publications with VTN and PLAUR
 TNFRSF11B antibody  >1 publications with VTN and TNFRSF11B
 TGFB1 antibody  >1 publications with VTN and TGFB1
 ITGB3 antibody  >1 publications with VTN and ITGB3
 ITGA8 antibody  >1 publications with VTN and ITGA8
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
Diseases associated with anti-VTN antibodyOrgans/Tissues associated with anti-VTN antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3 publications with VTN and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with VTN and Kidney Diseases
 Heart Diseases Antibodies  >2 publications with VTN and Heart Diseases
 Drug Toxicity Antibodies  >2 publications with VTN and Drug Toxicity
 Weight Loss Antibodies  >2 publications with VTN and Weight Loss
 Nervous System Diseases Antibodies  >1 publications with VTN and Nervous System Diseases
 Fibrosis Antibodies  >1 publications with VTN and Fibrosis
 Proteinuria Antibodies  >1 publications with VTN and Proteinuria
 Hypertension Antibodies  >1 publications with VTN and Hypertension
 Atherosclerosis Antibodies  >1 publications with VTN and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with VTN and Brain
 Blood Antibodies  >8 publications with VTN and Blood
 Heart Antibodies  >5 publications with VTN and Heart
 Lung Antibodies  >4 publications with VTN and Lung
 Kidney Antibodies  >3 publications with VTN and Kidney
 Eye Antibodies  >2 publications with VTN and Eye
 Placenta Antibodies  >2 publications with VTN and Placenta
 Pancreas Antibodies  >1 publications with VTN and Pancreas
 Embryonic Tissue Antibodies  >1 publications with VTN and Embryonic Tissue
 Uterus Antibodies  >1 publications with VTN and Uterus
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