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anti-VWF antibody :: Mouse von Willebrand Factor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190272 anti-VWF antibody
Unit / Price
0.2 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

von Willebrand Factor (VWF), Monoclonal Antibody

 Also Known As   

Human von Willebrand Factor (vWF) Monoclonal Antibody

 Product Synonym Names    von Willebrand Factor
 Product Gene Name   

anti-VWF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (6058040..6233836, complement). Location: 12p13.3
 OMIM    193400
 3D Structure    ModBase 3D Structure for P04275
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 Clonality    Monoclonal
 Clone Number    VW92-3
 Host    Mouse
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 Specificity    von Willebrand Factor [Mouse monoclonal antibody to von Willebrand Factor]
 Form/Format    200 ug IgG in 10 mM PBS, pH 7.4, lyophilized.
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 Antigen    Human plasma von Willebrand Factor.
 Activity and Specificity    This antibody specifically recognizes human von Willebrands Factor. This antibody does not inhibit the binding of vWF to the vitronectin receptor. This antibody does not react with bovine vWF.
Epitope: V8 Protease Fragment III; Ntermini Trypsin and Plasmin sensitive region
Subclass: IgG2a
 Stabilizer    1% BSA
 Preservatives    0.1% Sodium Azide
 Dilutions Instructions    Reconstitute in distilled water to the final desired concentration.
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 Preparation and Storage    Lyophilized antibody is stable at 4 degree C for 2 years. Store the reconstituted solution in aliquots at -20 degree C for one year or at 4 degree C for 6 months. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-VWF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VWF antibody    Coagulation Factor Monoclonal Antibodies
 Applications Tested/Suitable for anti-VWF antibody   

ELISA, Western Blot, Immunohistochemistry

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NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
 NCBI GI #    340356
 NCBI GeneID    7450
 NCBI Accession #    AAB59458.1 [Other Products]
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 UniProt Primary Accession #    P04275 [Other Products]
 UniProt Secondary Accession #    Q99806 [Other Products]
 UniProt Related Accession #    P04275; Q8TCE8 [Other Products]
 Molecular Weight    309,265 Da [Similar Products]
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 NCBI Official Full Name    von Willebrand factor
 NCBI Official Synonym Full Names    von Willebrand factor
 NCBI Official Symbol    VWF [Similar Products]
 NCBI Official Synonym Symbols   
VWD; F8VWF
[Similar Products]
 NCBI Protein Information    von Willebrand factor; OTTHUMP00000238431; coagulation factor VIII VWF
 UniProt Protein Name    von Willebrand factor
 UniProt Synonym Protein Names   
von Willebrand antigen II
 Protein Family    von Willebrand factor
 UniProt Gene Name    VWF [Similar Products]
 UniProt Synonym Gene Names    F8VWF [Similar Products]
 UniProt Entry Name    VWF_HUMAN
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 NCBI Summary for VWF    The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq]
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 UniProt Comments for VWF    VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.

Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region; external side of plasma membrane

Molecular Function: integrin binding; collagen binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; chaperone binding; immunoglobulin binding; protein N-terminus binding; glycoprotein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; hemostasis; response to wounding; cell adhesion; blood coagulation; liver development; blood coagulation, intrinsic pathway; cell-substrate adhesion; protein homooligomerization; placenta development

Disease: Von Willebrand Disease, Type 3; Von Willebrand Disease, Type 1; Von Willebrand Disease, Type 2
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 Research Articles on VWF    1. Data show that the baseline levels of both vWF and sES were higher in the patients with PHPT, while at the 6-month follow-up, vWF decreased significantly and sES was normal.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VWF antibodyPathways associated with anti-VWF antibody
 Reference Product  PubMed Publications
 ADAMTS13 antibody  >443 publications with VWF and ADAMTS13
 FURIN antibody  >24 publications with VWF and FURIN
 GP1BA antibody  >10 publications with VWF and GP1BA
 TNFRSF11B antibody  >6 publications with VWF and TNFRSF11B
 ITGA2B antibody  >6 publications with VWF and ITGA2B
 COL1A2 antibody  >1 publications with VWF and COL1A2
 COL1A1 antibody  >1 publications with VWF and COL1A1
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with anti-VWF antibodyOrgans/Tissues associated with anti-VWF antibody
 Disease Name  Pubmed Publications
 von Willebrand Diseases Antibodies  >1740 publications with VWF and von Willebrand Diseases
 Cardiovascular Diseases Antibodies  >1609 publications with VWF and Cardiovascular Diseases
 Thrombosis Antibodies  >1170 publications with VWF and Thrombosis
 Inflammation Antibodies  >432 publications with VWF and Inflammation
 Purpura Antibodies  >397 publications with VWF and Purpura
 Thrombophilia Antibodies  >392 publications with VWF and Thrombophilia
 Neoplasms Antibodies  >374 publications with VWF and Neoplasms
 Coronary Disease Antibodies  >278 publications with VWF and Coronary Disease
 Kidney Diseases Antibodies  >274 publications with VWF and Kidney Diseases
 Arteriosclerosis Antibodies  >243 publications with VWF and Arteriosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4905 publications with VWF and Blood
 Vascular Antibodies  >2446 publications with VWF and Vascular
 Heart Antibodies  >466 publications with VWF and Heart
 Muscle Antibodies  >281 publications with VWF and Muscle
 Bone Antibodies  >255 publications with VWF and Bone
 Umbilical Cord Antibodies  >228 publications with VWF and Umbilical Cord
 Kidney Antibodies  >226 publications with VWF and Kidney
 Liver Antibodies  >206 publications with VWF and Liver
 Skin Antibodies  >205 publications with VWF and Skin
 Brain Antibodies  >187 publications with VWF and Brain
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