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anti-NEIL3 antibody :: Rabbit anti-Human, Mouse NEIL3 Antibody

Scan QR to view Datasheet Catalog #    MBS851221
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NEIL3, Antibody

 Also Known As   

NEIL3 Antibody

 Product Synonym Names    Endonuclease VIII-like 3; Nei-like 3; DNA glycosylase FPG2
 Product Gene Name   

anti-NEIL3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608934
 3D Structure    ModBase 3D Structure for Q8TAT5
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 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    NEIL3 antibody detects endogenous levels of total NEIL3 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human NEIL3.
 Pathway    Transcription
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-NEIL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NEIL3 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-NEIL3 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-NEIL3 antibody    WB: 1:500~1:1000, ELISA: 1:40000
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 Testing Data of anti-NEIL3 antibody    Western blot analysis of extracts from COLO cells, HUVEC cells, HepG2 cells and HeLa cells, using NEIL3 antibody.
For Research Use Only
anti-NEIL3 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for NEIL3. It may not necessarily be applicable to this product.
 NCBI GI #    157388969
 NCBI GeneID    55247
 NCBI Accession #    NP_060718.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_018248.2 [Other Products]
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 UniProt Primary Accession #    Q8TAT5 [Other Products]
 UniProt Secondary Accession #    Q2PPJ3; Q8NG51; Q9NV95 [Other Products]
 UniProt Related Accession #    Q8TAT5 [Other Products]
 Molecular Weight    67,769 Da
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 NCBI Official Full Name    endonuclease 8-like 3
 NCBI Official Synonym Full Names    nei endonuclease VIII-like 3 (E. coli)
 NCBI Official Symbol    NEIL3 [Similar Products]
 NCBI Official Synonym Symbols   
FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3
[Similar Products]
 NCBI Protein Information    endonuclease 8-like 3; nei-like protein 3; DNA glycosylase FPG2; DNA glycosylase hFPG2; endonuclease VIII-like 3; DNA glycosylase/AP lyase Neil3; zinc finger, GRF-type containing 3
 UniProt Protein Name    Endonuclease 8-like 3
 UniProt Synonym Protein Names   
DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3
 Protein Family    Endonuclease
 UniProt Gene Name    NEIL3 [Similar Products]
 UniProt Entry Name    NEIL3_HUMAN
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 NCBI Summary for NEIL3    NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for NEIL3    NEIL3: Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single- stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected. Belongs to the FPG family.

Protein type: EC 4.2.99.18; DNA-binding

Chromosomal Location of Human Ortholog: 4q34.3

Cellular Component: nucleus

Molecular Function: DNA-(apurinic or apyrimidinic site) lyase activity; zinc ion binding; double-stranded DNA binding; DNA N-glycosylase activity; damaged DNA binding; bubble DNA binding; single-stranded DNA binding

Biological Process: base-excision repair; nucleotide-excision repair; DNA catabolic process, endonucleolytic
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Product References and Citations for anti-NEIL3 antibody

   Takao M., J. Biol. Chem. 277:42205-42213(2002).
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
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 Research Articles on NEIL3    1. Polymorphisms within FLT3, EGFR, NEIL3, and ALOX5 may contribute to the occurrence of GBM.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NEIL3 antibodyDiseases associated with anti-NEIL3 antibody
 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >1 publications with NEIL3 and Liver Diseases
 Ovarian Diseases Antibodies  >1 publications with NEIL3 and Ovarian Diseases
 Adenocarcinoma Antibodies  >1 publications with NEIL3 and Adenocarcinoma
 Liver Neoplasms, Experimental Antibodies  >1 publications with NEIL3 and Liver Neoplasms, Experimental
 Prostatic Neoplasms Antibodies  >1 publications with NEIL3 and Prostatic Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with NEIL3 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with NEIL3 and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with NEIL3 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >1 publications with NEIL3 and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-NEIL3 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with NEIL3 and Brain
 Embryonic Tissue Antibodies  >3 publications with NEIL3 and Embryonic Tissue
 Liver Antibodies  >2 publications with NEIL3 and Liver
 Blood Antibodies  >2 publications with NEIL3 and Blood
 Bone Antibodies  >1 publications with NEIL3 and Bone
 Thymus Antibodies  >1 publications with NEIL3 and Thymus
 Heart Antibodies  >1 publications with NEIL3 and Heart
 Bone Marrow Antibodies  >1 publications with NEIL3 and Bone Marrow
 Testis Antibodies  >1 publications with NEIL3 and Testis
 Lymph Node Antibodies  >1 publications with NEIL3 and Lymph Node
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