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anti-RELA antibody :: Rabbit NF-kappaB p65 (Ab-276) Antibody

Scan QR to view Datasheet Catalog #    MBS000948 anti-RELA antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NF-kappaB p65 (Ab-276) (RELA), Antibody

 Also Known As   

Rabbit NF-kappaB p65 (Ab-276) Antibody

 Product Synonym Names    NF-kB p65 (Ab-276)
 Product Gene Name   

anti-RELA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (65421067..65430443, complement). Location: 11q13
 OMIM    164014
 3D Structure    ModBase 3D Structure for Q04206
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-RELA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-RELA antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for RELA. It may not necessarily be applicable to this product.
 NCBI GI #    223468681
 NCBI GeneID    5970
 NCBI Accession #    NP_001138610.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145138.1 [Other Products]
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 UniProt Primary Accession #    Q04206 [Other Products]
 UniProt Secondary Accession #    Q6GTV1; Q6SLK1 [Other Products]
 UniProt Related Accession #    Q04206 [Other Products]
 Molecular Weight    60,219 Da [Similar Products]
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 NCBI Official Full Name    transcription factor p65 isoform 2
 NCBI Official Synonym Full Names    v-rel reticuloendotheliosis viral oncogene homolog A (avian)
 NCBI Official Symbol    RELA [Similar Products]
 NCBI Official Synonym Symbols   
p65; NFKB3
[Similar Products]
 NCBI Protein Information    transcription factor p65; NF-kappa-B p65delta3; nuclear factor NF-kappa-B p65 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
 UniProt Protein Name    Transcription factor p65
 UniProt Synonym Protein Names   
Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
 Protein Family    Transcription factor
 UniProt Gene Name    RELA [Similar Products]
 UniProt Synonym Gene Names    NFKB3 [Similar Products]
 UniProt Entry Name    TF65_HUMAN
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 NCBI Summary for RELA    NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for RELA    NFkB-p65: a subunit of NF-kappa-B transcription complex, which plays a crucial role in inflammatory and immune responses. The inhibitory effect of I-kappa-B upon NF-kappa-B in the cytoplasm is exerted primarily through the interaction with p65. P65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Three splice-variant isoforms have been identified.

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; NF-kappaB binding; identical protein binding; protein binding; DNA binding; transcription activator binding; protein heterodimerization activity; ubiquitin protein ligase binding; protein complex binding; protein N-terminus binding; chromatin binding; phosphate binding; transcription factor activity; transcription factor binding; protein kinase binding

Biological Process: nerve growth factor receptor signaling pathway; viral reproduction; positive regulation of transcription, DNA-dependent; negative regulation of insulin receptor signaling pathway; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; hair follicle development; defense response to virus; toll-like receptor 4 signaling pathway; response to drug; positive regulation of I-kappaB kinase/NF-kappaB cascade; membrane protein intracellular domain proteolysis; acetaldehyde metabolic process; response to amino acid stimulus; toll-like receptor 2 signaling pathway; organ morphogenesis; positive regulation of chondrocyte differentiation; response to muramyl dipeptide; response to mechanical stimulus; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of transcription, DNA-dependent; negative regulation of protein catabolic process; response to progesterone stimulus; negative regulation of apoptosis; transcription from RNA polymerase II promoter; response to cAMP; response to morphine; negative regulation of transcription from RNA polymerase II promoter; response to insulin stimulus; toll-like receptor 10 signaling pathway; response to organic substance; positive regulation of cell proliferation; positive regulation of interferon type I production; inflammatory response; aging; positive regulation of Schwann cell differentiation; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; liver development; response to UV-B; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-12 biosynthetic process; regulation of inflammatory response; toll-like receptor signaling pathway; cellular defense response; innate immune response; response to cobalamin
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 Research Articles on RELA    1. Ultraviolet radiation also upregulated mitogen-activated protein kinases and nuclear factor-kappaB/p65 expression via Toll-like receptor 2 and Toll-like receptor 4, and upregulated interferon regulatory factor-3 expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RELA antibodyPathways associated with anti-RELA antibody
 Reference Product  PubMed Publications
 REL antibody  >666 publications with RELA and REL
 JUN antibody  >638 publications with RELA and JUN
 IKBKB antibody  >457 publications with RELA and IKBKB
 RELB antibody  >261 publications with RELA and RELB
 CHUK antibody  >152 publications with RELA and CHUK
 NFKB1 antibody  >92 publications with RELA and NFKB1
 NFKB2 antibody  >89 publications with RELA and NFKB2
 CCND1 antibody  >82 publications with RELA and CCND1
 SP1 antibody  >67 publications with RELA and SP1
 MYC antibody  >65 publications with RELA and MYC
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
Diseases associated with anti-RELA antibodyOrgans/Tissues associated with anti-RELA antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1348 publications with RELA and Necrosis
 Inflammation Antibodies  >1055 publications with RELA and Inflammation
 Neoplasms Antibodies  >899 publications with RELA and Neoplasms
 Liver Diseases Antibodies  >246 publications with RELA and Liver Diseases
 Nervous System Diseases Antibodies  >191 publications with RELA and Nervous System Diseases
 Drug Toxicity Antibodies  >177 publications with RELA and Drug Toxicity
 Brain Diseases Antibodies  >143 publications with RELA and Brain Diseases
 Kidney Diseases Antibodies  >109 publications with RELA and Kidney Diseases
 Breast Neoplasms Antibodies  >106 publications with RELA and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >90 publications with RELA and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >991 publications with RELA and Blood
 Liver Antibodies  >504 publications with RELA and Liver
 Vascular Antibodies  >452 publications with RELA and Vascular
 Lung Antibodies  >346 publications with RELA and Lung
 Muscle Antibodies  >238 publications with RELA and Muscle
 Brain Antibodies  >238 publications with RELA and Brain
 Bone Antibodies  >192 publications with RELA and Bone
 Kidney Antibodies  >177 publications with RELA and Kidney
 Intestine Antibodies  >158 publications with RELA and Intestine
 Heart Antibodies  >145 publications with RELA and Heart
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