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anti-RELA antibody :: NF-kappaB p65 Antibody

Scan QR to view Datasheet Catalog #    MBS853295
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NF-kappaB p65 (RELA), Antibody

 Also Known As   

NF-kappaB p65 (Ab-281) Antibody

 Product Gene Name   

anti-RELA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164014
 3D Structure    ModBase 3D Structure for Q04206
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 Other Notes    Small volumes of anti-RELA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Immunohistochemistry of anti-RELA antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using NF-kappaB p65 (Ab-281) antibody
anti-RELA antibody Immunohistochemistry (IHC) image
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 Western Blot of anti-RELA antibody    Western blot analysis of extracts from HUVEC cells, treated with EPO (20U/ml, 15mins), using NF-kappaB p65 (Ab-281) antibody.
anti-RELA antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for RELA. It may not necessarily be applicable to this product.
 NCBI GI #    223468681
 NCBI GeneID    5970
 NCBI Accession #    NP_001138610.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145138.1 [Other Products]
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 UniProt Primary Accession #    Q04206 [Other Products]
 UniProt Secondary Accession #    Q6GTV1; Q6SLK1 [Other Products]
 UniProt Related Accession #    Q04206 [Other Products]
 Molecular Weight    59,910 Da [Similar Products]
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 NCBI Official Full Name    transcription factor p65 isoform 2
 NCBI Official Synonym Full Names    RELA proto-oncogene, NF-kB subunit
 NCBI Official Symbol    RELA [Similar Products]
 NCBI Official Synonym Symbols   
p65; NFKB3
[Similar Products]
 NCBI Protein Information    transcription factor p65
 UniProt Protein Name    Transcription factor p65
 UniProt Synonym Protein Names   
Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
 Protein Family    Transcription factor
 UniProt Gene Name    RELA [Similar Products]
 UniProt Synonym Gene Names    NFKB3 [Similar Products]
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 NCBI Summary for RELA    NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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 UniProt Comments for RELA    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
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 Research Articles on RELA    1. Taken together, these data indicate that up-regulation of ANXA4 leads to activation of the NF-kappaB pathway and its target genes in a feedback regulatory mechanism via the p65 subunit, resulting in tumor growth in GBC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RELA antibodyPathways associated with anti-RELA antibody
 Reference Product  PubMed Publications
 REL antibody  >666 publications with RELA and REL
 JUN antibody  >638 publications with RELA and JUN
 IKBKB antibody  >457 publications with RELA and IKBKB
 RELB antibody  >261 publications with RELA and RELB
 CHUK antibody  >152 publications with RELA and CHUK
 NFKB1 antibody  >92 publications with RELA and NFKB1
 NFKB2 antibody  >89 publications with RELA and NFKB2
 CCND1 antibody  >82 publications with RELA and CCND1
 SP1 antibody  >67 publications with RELA and SP1
 MYC antibody  >65 publications with RELA and MYC
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
Diseases associated with anti-RELA antibodyOrgans/Tissues associated with anti-RELA antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1348 publications with RELA and Necrosis
 Inflammation Antibodies  >1055 publications with RELA and Inflammation
 Neoplasms Antibodies  >899 publications with RELA and Neoplasms
 Liver Diseases Antibodies  >246 publications with RELA and Liver Diseases
 Nervous System Diseases Antibodies  >191 publications with RELA and Nervous System Diseases
 Drug Toxicity Antibodies  >177 publications with RELA and Drug Toxicity
 Brain Diseases Antibodies  >143 publications with RELA and Brain Diseases
 Kidney Diseases Antibodies  >109 publications with RELA and Kidney Diseases
 Breast Neoplasms Antibodies  >106 publications with RELA and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >90 publications with RELA and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >991 publications with RELA and Blood
 Liver Antibodies  >504 publications with RELA and Liver
 Vascular Antibodies  >452 publications with RELA and Vascular
 Lung Antibodies  >346 publications with RELA and Lung
 Muscle Antibodies  >238 publications with RELA and Muscle
 Brain Antibodies  >238 publications with RELA and Brain
 Bone Antibodies  >192 publications with RELA and Bone
 Kidney Antibodies  >177 publications with RELA and Kidney
 Intestine Antibodies  >158 publications with RELA and Intestine
 Heart Antibodies  >145 publications with RELA and Heart
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