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anti-NFKB2 antibody :: NFkappaB-p100/p52 Antibody

Scan QR to view Datasheet Catalog #    MBS857665
Unit / Price
0.05 mg  /  $180 +1 FREE 8GB USB
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NFkappaB-p100/p52 (NFKB2), Antibody

 Also Known As   

NFkappaB-p100/p52 (Ab-865) Antibody

 Product Gene Name   

anti-NFKB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164012
 3D Structure    ModBase 3D Structure for Q00653
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    NF-kappaB p100/p52 (Ab-865) antibody detects endogenous levels of NF-kappaB p100/p52 protein around serine 865.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human NF-kappaB p100/p52 around the phosphorylation site of serine 865 (E-D-SP-A-Y).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-NFKB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NFKB2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-NFKB2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-NFKB2 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
IF: 1:100~1:200
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 Immunohistochemistry (IHC) of anti-NFKB2 antibody    Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NF-kappaB p100/p52 (Ab-865) antibody.
anti-NFKB2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-NFKB2 antibody    Western blot analysis of extracts from ovary cancer cells using NF-kappaB p100/p52 (Ab-865) antibody.
anti-NFKB2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NFKB2. It may not necessarily be applicable to this product.
 NCBI GI #    117320531
 NCBI GeneID    4791
 NCBI Accession #    NP_001070962.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001077494.3 [Other Products]
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 UniProt Primary Accession #    Q00653 [Other Products]
 UniProt Secondary Accession #    Q04860; Q9BU75; Q9H471; Q9H472; A8K9D9; D3DR83 [Other Products]
 UniProt Related Accession #    Q00653 [Other Products]
 Molecular Weight    96,678 Da [Similar Products]
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 NCBI Official Full Name    nuclear factor NF-kappa-B p100 subunit isoform a
 NCBI Official Synonym Full Names    nuclear factor kappa B subunit 2
 NCBI Official Symbol    NFKB2 [Similar Products]
 NCBI Official Synonym Symbols   
p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100
[Similar Products]
 NCBI Protein Information    nuclear factor NF-kappa-B p100 subunit
 UniProt Protein Name    Nuclear factor NF-kappa-B p100 subunit
 UniProt Synonym Protein Names   
DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; Lyt10
 Protein Family    Nuclear factor
 UniProt Gene Name    NFKB2 [Similar Products]
 UniProt Synonym Gene Names    LYT10; Lyt10 [Similar Products]
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 NCBI Summary for NFKB2    This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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 UniProt Comments for NFKB2    NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
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Product References and Citations for anti-NFKB2 antibody

   Qu Z, et al. (2004) J Biol Chem. 279(43): 44563-44572. Xiao G, et al. (2001) Mol Cell. 7(2): 401-409. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.
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 Research Articles on NFKB2    1. This study demonstrated that NF-kappaB mRNA levels were significantly decreased in the new cases of untreated MS patients in comparison to healthy controls.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFKB2 antibodyPathways associated with anti-NFKB2 antibody
 Reference Product  PubMed Publications
 RELA antibody  >89 publications with NFKB2 and RELA
 RELB antibody  >88 publications with NFKB2 and RELB
 REL antibody  >85 publications with NFKB2 and REL
 IKBKB antibody  >53 publications with NFKB2 and IKBKB
 NFKB1 antibody  >48 publications with NFKB2 and NFKB1
 CHUK antibody  >18 publications with NFKB2 and CHUK
 BCL3 antibody  >11 publications with NFKB2 and BCL3
 NFKBIA antibody  >3 publications with NFKB2 and NFKBIA
 IKBKG antibody  >3 publications with NFKB2 and IKBKG
 NFKBIE antibody  >3 publications with NFKB2 and NFKBIE
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Alternative NF-kappaB Pathway antibodies  Alternative NF-kappaB Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DAI Mediated Induction Of Type I IFNs Pathway antibodies  DAI Mediated Induction Of Type I IFNs Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 EBV LMP1 Signaling Pathway antibodies  EBV LMP1 Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
Diseases associated with anti-NFKB2 antibodyOrgans/Tissues associated with anti-NFKB2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >99 publications with NFKB2 and Neoplasms
 Necrosis Antibodies  >66 publications with NFKB2 and Necrosis
 Immune System Diseases Antibodies  >54 publications with NFKB2 and Immune System Diseases
 Inflammation Antibodies  >45 publications with NFKB2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >17 publications with NFKB2 and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >13 publications with NFKB2 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >13 publications with NFKB2 and Breast Neoplasms
 Lung Diseases Antibodies  >9 publications with NFKB2 and Lung Diseases
 Neoplasms, Experimental Antibodies  >7 publications with NFKB2 and Neoplasms, Experimental
 Liver Diseases Antibodies  >6 publications with NFKB2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >88 publications with NFKB2 and Blood
 Bone Antibodies  >34 publications with NFKB2 and Bone
 Bone Marrow Antibodies  >24 publications with NFKB2 and Bone Marrow
 Spleen Antibodies  >15 publications with NFKB2 and Spleen
 Lung Antibodies  >13 publications with NFKB2 and Lung
 Lymph Node Antibodies  >12 publications with NFKB2 and Lymph Node
 Lymph Antibodies  >11 publications with NFKB2 and Lymph
 Brain Antibodies  >11 publications with NFKB2 and Brain
 Kidney Antibodies  >10 publications with NFKB2 and Kidney
 Prostate Antibodies  >10 publications with NFKB2 and Prostate
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