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NGFR antibody :: NGF-Receptor (p75) /CD271 Antibody

Scan QR to view Datasheet Catalog #    MBS439581
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NGF-Receptor (p75) /CD271 (NGFR), Antibody

 Also Known As   

NGF-Receptor (p75) /CD271 (Soft Tissue Tumor Marker) Mouse Monoclonal Antibody

 Product Synonym Names    CD271; Gp80-LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Nerve growth factor receptor (NGFR); TNFR superfamily member 16; p75 ICD; p75 Neurotrophin receptor; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)
 Product Gene Name   

NGFR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    162010
 3D Structure    ModBase 3D Structure for P08138
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    SPM299
 Host    Mouse
 Species Reactivity    Human, Monkey, Baboon, Cat, Rabbit, Ferret.
Does not react with Mouse and Rat
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 Specificity    It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cell Surface and Cytoplasmic
 Immunogen    NGFR from A875 melanoma cells
 Hu-Chromosome Location    17q21-22
 Positive Control    Neuronal axons, Schwann cells, and perineural cells of peripheral nerves, or tumors of nerve sheath differentiation e.g. Schwannoma, Neurofibroma. Soma and axons of sensory neurons, and ganglionic satellite cells. Melanomas.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of NGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for NGFR antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for NGFR antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of NGFR antibody    Formalin-fixed, paraffin-embedded human Melanoma stained with NGFR Monoclonal Antibody (SPM299).
NGFR antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.
 NCBI GI #    4505393
 NCBI GeneID    4804
 NCBI Accession #    NP_002498.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002507.3 [Other Products]
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 UniProt Primary Accession #    P08138 [Other Products]
 UniProt Secondary Accession #    B2R961; B4E096 [Other Products]
 UniProt Related Accession #    P08138 [Other Products]
 Molecular Weight    75kDa
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 16
 NCBI Official Synonym Full Names    nerve growth factor receptor
 NCBI Official Symbol    NGFR [Similar Products]
 NCBI Official Synonym Symbols   
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 16
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 16
 UniProt Synonym Protein Names   
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    NGFR [Similar Products]
 UniProt Synonym Gene Names    TNFRSF16; NGF receptor [Similar Products]
 UniProt Entry Name    TNR16_HUMAN
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 NCBI Summary for NGFR    Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NGFR    NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: cell surface; cytosol; endosome; extracellular region; integral to plasma membrane; neuron projection; nucleoplasm; nucleus; plasma membrane

Molecular Function: nerve growth factor binding; protein binding; Rab GTPase binding; receptor activity; signal transducer activity; transmembrane receptor activity; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: axon guidance; caspase activation; circadian regulation of gene expression; glucose homeostasis; immune response; inflammatory response; intracellular protein transport; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of caspase activity; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of axonogenesis; positive regulation of MAPKKK cascade; regulation of apoptosis; regulation of caspase activity; regulation of cell proliferation; response to lipopolysaccharide
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Product References and Citations for NGFR antibody

   Marano N, et. al. Journal of Neurochemistry, 1987, 48:225-32.
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 Research Articles on NGFR    1. Findings show no association of SNPs in NTRK2 and NGFR genes with completed suicide in Slovenian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NGFR antibody Pathways associated with NGFR antibody
 Reference Product  PubMed Publications
 NGF antibody  >270 publications with NGFR and NGF
 BDNF antibody  >62 publications with NGFR and BDNF
 NTRK1 antibody  >16 publications with NGFR and NTRK1
 NTRK2 antibody  >14 publications with NGFR and NTRK2
 NTF3 antibody  >5 publications with NGFR and NTF3
 RTN4R antibody  >4 publications with NGFR and RTN4R
 LINGO1 antibody  >2 publications with NGFR and LINGO1
 TRAF6 antibody  >2 publications with NGFR and TRAF6
 NGFRAP1 antibody  >1 publications with NGFR and NGFRAP1
 Products by Pathway  Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Apoptosis - Multiple Species Pathway antibodies  Apoptosis - Multiple Species Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Axonal Growth Stimulation Pathway antibodies  Axonal Growth Stimulation Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Ceramide Signalling Pathway antibodies  Ceramide Signalling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 NADE Modulates Death Signalling Pathway antibodies  NADE Modulates Death Signalling Pathway Diagram
Diseases associated with NGFR antibody Organs/Tissues associated with NGFR antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >137 publications with NGFR and Nervous System Diseases
 Brain Diseases Antibodies  >66 publications with NGFR and Brain Diseases
 Necrosis Antibodies  >49 publications with NGFR and Necrosis
 Neurodegenerative Diseases Antibodies  >41 publications with NGFR and Neurodegenerative Diseases
 Nerve Degeneration Antibodies  >36 publications with NGFR and Nerve Degeneration
 Disease Models, Animal Antibodies  >34 publications with NGFR and Disease Models, Animal
 Inflammation Antibodies  >31 publications with NGFR and Inflammation
 Pain Antibodies  >19 publications with NGFR and Pain
 Prostatic Neoplasms Antibodies  >19 publications with NGFR and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >18 publications with NGFR and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >712 publications with NGFR and Nerve
 Brain Antibodies  >223 publications with NGFR and Brain
 Bone Antibodies  >80 publications with NGFR and Bone
 Skin Antibodies  >65 publications with NGFR and Skin
 Embryonic Tissue Antibodies  >51 publications with NGFR and Embryonic Tissue
 Mouth Antibodies  >40 publications with NGFR and Mouth
 Connective Tissue Antibodies  >28 publications with NGFR and Connective Tissue
 Eye Antibodies  >28 publications with NGFR and Eye
 Kidney Antibodies  >27 publications with NGFR and Kidney
 Prostate Antibodies  >20 publications with NGFR and Prostate
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