NP_057562.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,262 Da
NCBI Official Full Name
nuclear-interacting partner of ALK
NCBI Official Synonym Full Names
zinc finger, C3HC-type containing 1
NCBI Protein Information
nuclear-interacting partner of ALK; hNIPA; zinc finger, C3HC type 1; zinc finger C3HC-type protein 1; nuclear interaction partner of ALK; hematopoietic stem/progenitor cell protein 216; nuclear-interacting partner of anaplastic lymphoma kinase; nuclear interacting partner of anaplastic lymphoma kinase (ALK)
UniProt Protein Name
Nuclear-interacting partner of ALK
UniProt Synonym Protein Names
Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC-type protein 1
UniProt Synonym Gene Names
UniProt Entry Name
NIPA_HUMAN
NCBI Summary for NIPA
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
UniProt Comments for NIPA
NIPA: a nuclear protein that interacts with anaplastic lymphoma kinase (ALK). An essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1. Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting cyclin B1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of cyclin B1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Three splice-variant isoforms have been described.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 7q32.2
Cellular Component: nuclear membrane; nucleus
Molecular Function: protein binding; zinc ion binding; protein kinase binding
Biological Process: mitosis; cell division; protein ubiquitination
Research Articles on NIPA
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Products associated with anti-NIPA antibody
Diseases associated with anti-NIPA antibody
Organs/Tissues associated with anti-NIPA antibody
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