NP_000823.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,851 Da
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 1 isoform GluN1-4a
NCBI Official Synonym Full Names
glutamate ionotropic receptor NMDA type subunit 1
NCBI Official Synonym Symbols
NR1; MRD8; GluN1; NMDA1; NDHMSD; NDHMSR; NMD-R1; NMDAR1 [Similar Products]
NCBI Protein Information
glutamate receptor ionotropic, NMDA 1
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 1
UniProt Synonym Protein Names
Glutamate [NMDA] receptor subunit zeta-1; N-methyl-D-aspartate receptor subunit NR1; NMD-R1
UniProt Synonym Gene Names
NCBI Summary for NMDAR1
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for NMDAR1
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+ (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).
Product References and Citations for anti-NMDAR1 antibody
Foldes R.L., Gene 131:293-298(1993). Karp S.J., J. Biol. Chem. 268:3728-3733(1993). Planells-Cases R., Proc. Natl. Acad. Sci. U.S.A. 90:5057-5061(1993).
Research Articles on NMDAR1
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Products associated with anti-NMDAR1 antibody
Pathways associated with anti-NMDAR1 antibody
Diseases associated with anti-NMDAR1 antibody
Organs/Tissues associated with anti-NMDAR1 antibody
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