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anti-NR3C1 antibody :: Mouse anti-Human NR3C1 Antibody

Scan QR to view Datasheet Catalog #    MBS850459
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NR3C1, Antibody

 Also Known As   

NR3C1 Antibody

 Product Synonym Names    GR; GCR; GRL; GCCR; NR3C1
 Product Gene Name   

anti-NR3C1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138040
 3D Structure    ModBase 3D Structure for P04150
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 Isotype    IgG1
 Clone Number    6E6
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of human NR3C1 expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-NR3C1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NR3C1 antibody

   The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Tissue specificity: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
 Product Categories/Family for anti-NR3C1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-NR3C1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-NR3C1 antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
IF: 1:200-1:1000
FC: 1:200-1:400
ELISA: 1:10000
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 Western Blot (WB) of anti-NR3C1 antibody    Figure 1: Western blot analysis using NR3C1 mouse mAb against Hela cell lysate.
anti-NR3C1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-NR3C1 antibody    Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using NR3C1 mouse mAb with DAB staining.
anti-NR3C1 antibody Immunohistochemistry (IHC) (IHC) image
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 Testing Data of anti-NR3C1 antibody    anti-NR3C1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for NR3C1. It may not necessarily be applicable to this product.
 NCBI GI #    4504133
 NCBI GeneID    2908
 NCBI Accession #    NP_000167.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000176.2 [Other Products]
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 UniProt Primary Accession #    P04150 [Other Products]
 UniProt Secondary Accession #    P04151; Q53EP5; Q6N0A4; A0ZXF9; B0LPG8; D3DQF4; F5ATB7 [Other Products]
 UniProt Related Accession #    P04150 [Other Products]
 Molecular Weight    86kDa
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 NCBI Official Full Name    glucocorticoid receptor isoform alpha
 NCBI Official Synonym Full Names    nuclear receptor subfamily 3 group C member 1
 NCBI Official Symbol    NR3C1 [Similar Products]
 NCBI Official Synonym Symbols   
GR; GCR; GRL; GCCR; GCRST
[Similar Products]
 NCBI Protein Information    glucocorticoid receptor
 UniProt Protein Name    Glucocorticoid receptor
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 3 group C member 1
 Protein Family    Glucocorticoid receptor
 UniProt Gene Name    NR3C1 [Similar Products]
 UniProt Synonym Gene Names    GRL; GR [Similar Products]
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 NCBI Summary for NR3C1    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
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 UniProt Comments for NR3C1    Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth ().
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 Research Articles on NR3C1    1. Study evaluated whether associations between early adversity and brain responses to dynamic facial expressions in early adulthood varied as a function of regional differences in the expression of NR3C1. Strongest associations between adversities and BOLD response to fearful faces were in brain regions with higher NR3C1 mRNA expression levels. Highest expression of NR3C1 is found in occipital and lowest in temporal regions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NR3C1 antibodyPathways associated with anti-NR3C1 antibody
 Reference Product  PubMed Publications
 JUN antibody  >22 publications with NR3C1 and JUN
 NR3C2 antibody  >15 publications with NR3C1 and NR3C2
 TP53 antibody  >3 publications with NR3C1 and TP53
 PPARGC1A antibody  >2 publications with NR3C1 and PPARGC1A
 HSP90AA1 antibody  >1 publications with NR3C1 and HSP90AA1
 HNRNPU antibody  >1 publications with NR3C1 and HNRNPU
 GRIP1 antibody  >1 publications with NR3C1 and GRIP1
 FKBP4 antibody  >1 publications with NR3C1 and FKBP4
 ETS1 antibody  >1 publications with NR3C1 and ETS1
 CREBBP antibody  >1 publications with NR3C1 and CREBBP
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
Diseases associated with anti-NR3C1 antibodyOrgans/Tissues associated with anti-NR3C1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >15 publications with NR3C1 and Nervous System Diseases
 Inflammation Antibodies  >15 publications with NR3C1 and Inflammation
 Hypertension Antibodies  >15 publications with NR3C1 and Hypertension
 Cardiovascular Diseases Antibodies  >14 publications with NR3C1 and Cardiovascular Diseases
 Depressive Disorder Antibodies  >12 publications with NR3C1 and Depressive Disorder
 Bipolar Disorder Antibodies  >9 publications with NR3C1 and Bipolar Disorder
 Brain Diseases Antibodies  >8 publications with NR3C1 and Brain Diseases
 Muscular Diseases Antibodies  >7 publications with NR3C1 and Muscular Diseases
 Drug Toxicity Antibodies  >7 publications with NR3C1 and Drug Toxicity
 Necrosis Antibodies  >6 publications with NR3C1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >58 publications with NR3C1 and Blood
 Brain Antibodies  >53 publications with NR3C1 and Brain
 Liver Antibodies  >16 publications with NR3C1 and Liver
 Placenta Antibodies  >10 publications with NR3C1 and Placenta
 Heart Antibodies  >8 publications with NR3C1 and Heart
 Nerve Antibodies  >7 publications with NR3C1 and Nerve
 Skin Antibodies  >7 publications with NR3C1 and Skin
 Pituitary Gland Antibodies  >5 publications with NR3C1 and Pituitary Gland
 Adipose Tissue Antibodies  >5 publications with NR3C1 and Adipose Tissue
 Intestine Antibodies  >5 publications with NR3C1 and Intestine
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