Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow NRL  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • XIAP (Phospho-Ser87) Antibody
 • CKII-beta (Phospho-Ser209) Antibody
 • Proinsulin (PINS) ELISA Kit
 • Vitamin B2 (VB2) ELISA Kit
 • High Mobility Group Nucleosome Binding Domain 1 (HMGN1) ELISA Kit
 • Soluble Interleukin 8 Receptor (SIL-8R-CD128) ELISA Kit
 • Glucose Transporter 2 (GLUT2) ELISA Kit
 • Ganglioside Antibody (GLS) ELISA Kit
 • Growth Hormone Inducible Transmembrane Protein (GHITM) ELISA Kit
 • B-Cell Cll-Lymphoma 10 (BCL10) ELISA Kit
 • Hepatitis B Virus Pre-S1 Antigen (HB-PS1AG) ELISA Kit
 • Gdp Dissociation Inhibitor 1 (GDI1) ELISA Kit
 • Ss-B-La Antibody ELISA Kit
 • Insulin-Like Growth Factor-2 (IGF-2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-NRL antibody :: Rabbit anti-Human, mouse NRL Antibody

Scan QR to view Datasheet Catalog #    MBS001448 anti-NRL antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NRL, Antibody

 Also Known As   

Rabbit NRL Antibody

 Product Gene Name   

anti-NRL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 14; NC_000014.8 (24549316..24553832, complement). Location: 14q11.1-q11.2
 OMIM    162080
 3D Structure    ModBase 3D Structure for P54845
Section Bar
 Host    Rabbit
 Species Reactivity    Human, mouse
Section Bar
 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
Section Bar
Section Bar
 Other Notes    Small volumes of anti-NRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-NRL antibody   

ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for NRL. It may not necessarily be applicable to this product.
 NCBI GI #    5453802
 NCBI GeneID    4901
 NCBI Accession #    NP_006168.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006177.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P54845 [Other Products]
 UniProt Secondary Accession #    Q53XD0 [Other Products]
 UniProt Related Accession #    P54845 [Other Products]
 Molecular Weight    25,940 Da
Table BarTOPTable Bar
 NCBI Official Full Name    neural retina-specific leucine zipper protein
 NCBI Official Synonym Full Names    neural retina leucine zipper
 NCBI Official Symbol    NRL [Similar Products]
 NCBI Official Synonym Symbols   
RP27; D14S46E; NRL-MAF
[Similar Products]
 NCBI Protein Information    neural retina-specific leucine zipper protein; neural retinal-specific leucine zipper
 UniProt Protein Name    Neural retina-specific leucine zipper protein
 Protein Family    Neural retina-specific leucine zipper protein
 UniProt Gene Name    NRL [Similar Products]
 UniProt Synonym Gene Names    D14S46E; NRL [Similar Products]
 UniProt Entry Name    NRL_HUMAN
Section Bar
 NCBI Summary for NRL    This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for NRL    NRL: Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. Defects in NRL are a cause of retinal degeneration autosomal recessive clumped pigment type (RDCP). A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present (clumped pigmentary retinal degeneration). Belongs to the bZIP family.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 14q11.1-q11.2

Cellular Component: nucleus

Molecular Function: leucine zipper domain binding; protein binding; DNA binding

Biological Process: transcription from RNA polymerase II promoter; retinal rod cell development; visual perception; positive regulation of rhodopsin gene expression; response to stimulus; positive regulation of transcription from RNA polymerase II promoter; regulation of rhodopsin gene expression

Disease: Retinitis Pigmentosa 27
Table BarTOPTable Bar
 Research Articles on NRL    1. This novel p.M96T mutant activated the RHO promoter more intensely than did wild-type NRL in a family with autosomal dominant retinitis pigmentosa.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-NRL antibodyDiseases associated with anti-NRL antibody
 Reference Product  PubMed Publications
 CRX antibody  >73 publications with NRL and CRX
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >99 publications with NRL and Skin Diseases
 Dermatitis Antibodies  >58 publications with NRL and Dermatitis
 Spinal Dysraphism Antibodies  >9 publications with NRL and Spinal Dysraphism
 Carcinoma, Hepatocellular Antibodies  >4 publications with NRL and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >4 publications with NRL and Liver Diseases
 Adenocarcinoma Antibodies  >3 publications with NRL and Adenocarcinoma
 Urogenital Abnormalities Antibodies  >1 publications with NRL and Urogenital Abnormalities
 Neurotoxicity Syndromes Antibodies  >1 publications with NRL and Neurotoxicity Syndromes
 Glioblastoma Antibodies  >1 publications with NRL and Glioblastoma
 Head and Neck Neoplasms Antibodies  >1 publications with NRL and Head and Neck Neoplasms
Organs/Tissues associated with anti-NRL antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >156 publications with NRL and Blood
 Brain Antibodies  >104 publications with NRL and Brain
 Liver Antibodies  >19 publications with NRL and Liver
 Eye Antibodies  >3 publications with NRL and Eye
 Embryonic Tissue Antibodies  >1 publications with NRL and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions