NP_689805.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nesprin-3
NCBI Official Synonym Full Names
spectrin repeat containing, nuclear envelope family member 3
NCBI Protein Information
nesprin-3; nuclear envelope spectrin repeat protein 3
UniProt Protein Name
Nesprin-3
UniProt Synonym Protein Names
Nuclear envelope spectrin repeat protein 3
UniProt Synonym Gene Names
UniProt Entry Name
SYNE3_HUMAN
UniProt Comments for SYNE3
SYNE3: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. Belongs to the nesprin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component: nuclear outer membrane; rough endoplasmic reticulum; membrane; integral to membrane; nuclear envelope
Molecular Function: actin filament binding; protein binding
Biological Process: regulation of cell shape; cytoskeleton organization and biogenesis
Research Articles on SYNE3
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