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anti-Neuropilin-1 (Paired T916) antibody :: Rabbit Neuropilin-1 (Paired T916) Antibody

Scan QR to view Datasheet Catalog #    MBS462091
Testing Data
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Neuropilin-1 (Paired T916) (Neuropilin-1 (Paired T916)), Antibody

★Popular Item★
 Also Known As   

Rabbit anti Neuropilin 1, Non-Phosphospecific

 Product Synonym Names    Rabbit anti-Neuropilin1 (Paired Thr916); CD304 antigen; NRP1; VEGF Receptor
 Product Gene Name   

anti-Neuropilin-1 (Paired T916) antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (33466419..33623833, complement). Location: 10p12
 OMIM    602069
 3D Structure    ModBase 3D Structure for O14786
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 Host    Rabbit
 Species Reactivity    Human, Bovine
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 Specificity    This antibody recognizes ~130 kDa of human Neuropilin1 protein without phosphorylation site of Thr 916. It does not cross react to phospho Neuropilin 1. The other species are not tested.
 Purity/Purification    The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide surrounding the epitope -LNTQS- without phosphorylation site at Thr916. This sequence is identical among human and bovine.
 Positive Control    Human Brain Tissue
 Cellular Location    Cytoplasmic
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C -8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-Neuropilin-1 (Paired T916) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Neuropilin-1 (Paired T916) antibody

   The neuropilin-1 (Nrp1) is a multifunctional protein, identified principally as a receptor for the class 3 semaphorins and members of the vascular endothelial growth factor (VEGF) family, but it is capable of other interactions. It is a marker of regulatory T cells (Tr), which often carry Nrp1 and latency-associated peptide (LAP)-TGF-beta1 (the latent form). Nrp1 is reported to be expressed in breast cancer cells. The ischemia can increase neuropilin 1 protein expression in experimental rat brain as well. The phosphorylation of Nrp1 is essential for the Nrp1 activation.
 Applications Tested/Suitable for anti-Neuropilin-1 (Paired T916) antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-Neuropilin-1 (Paired T916) antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 1:200
Optimal dilutions should be determined by researchers for the specific applications.
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 Testing Data of anti-Neuropilin-1 (Paired T916) antibody    anti-Neuropilin-1 (Paired T916) antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Neuropilin-1 (Paired T916). It may not necessarily be applicable to this product.
 NCBI GI #    182508169
 NCBI GeneID    8829
 NCBI Accession #    NP_003864.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_003873.5 [Other Products]
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 UniProt Primary Accession #    O14786 [Other Products]
 UniProt Secondary Accession #    O60461; Q5T7F2; Q5T7F3; Q86T59; Q96IH5; B0LPG9 [Other Products]
 UniProt Related Accession #    O14786; Q59F20; Q5JWQ0; Q5JWQ1; Q5JWQ2; Q5JWQ4; Q5JWQ5; Q5JWQ6; Q5T7F0; Q5T7F1 [Other Products]
 Molecular Weight    130 kDa
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 NCBI Official Full Name    neuropilin-1 isoform a
 NCBI Official Synonym Full Names    neuropilin 1
 NCBI Official Symbol    NRP1 [Similar Products]
 NCBI Official Synonym Symbols   
NP1; NRP; BDCA4; CD304; VEGF165R; DKFZp781F1414; DKFZp686A03134
[Similar Products]
 NCBI Protein Information    neuropilin-1; OTTHUMP00000020818; OTTHUMP00000020819; OTTHUMP00000020820; OTTHUMP00000020821; OTTHUMP00000020822; transmembrane receptor; vascular endothelial cell growth factor 165 receptor
 UniProt Protein Name    Neuropilin-1
 UniProt Synonym Protein Names   
Vascular endothelial cell growth factor 165 receptor
 UniProt Gene Name    NRP1 [Similar Products]
 UniProt Synonym Gene Names    NRP; VEGF165R [Similar Products]
 UniProt Entry Name    NRP1_HUMAN
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 NCBI Summary for Neuropilin-1 (Paired T916)    NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]
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 UniProt Comments for Neuropilin-1 (Paired T916)    Function: The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subunit structure: Homodimer, and heterodimer with NRP2. Binds PLXNB1. Ref.17

Subcellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue specificity: The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Domain: The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding.

Sequence similarities: Belongs to the neuropilin family.Contains 2 CUB domains.Contains 2 F5/8 type C domains.Contains 1 MAM domain.
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Product References and Citations for anti-Neuropilin-1 (Paired T916) antibody

   Eldar Hochman et al. Molecular Pathways Regulating Pro-migratory Effects of Hedgehog Signaling. J. Biol. Chem., Vol. 281, Issue 45, 33860-33870, November 10, 2006 Glinka Y, et al. Neuropilin-1 is a receptor for transforming growth factor beta-1, activates its latent form, and promotes regulatory T cell activity. J Leukoc Biol. 2008 Jul; 84 (1): 302-10. Epub 2008 Apr 24
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 Research Articles on Neuropilin-1 (Paired T916)    1. These results indicate a role for NRP1 and NRP1 glycosylation in mediating PDGF-induced VSMC migration, possibly by acting as a co-receptor for PDGFRalpha and via selective mobilization of a novel p130Cas tyrosine phosphorylation pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Neuropilin-1 (Paired T916) antibodyPathways associated with anti-Neuropilin-1 (Paired T916) antibody
 Reference Product  PubMed Publications
 NRP2 antibody  >73 publications with Neuropilin-1 (Paired T916) and NRP2
 SEMA3A antibody  >50 publications with Neuropilin-1 (Paired T916) and SEMA3A
 VEGFA antibody  >37 publications with Neuropilin-1 (Paired T916) and VEGFA
 SEMA3F antibody  >20 publications with Neuropilin-1 (Paired T916) and SEMA3F
 KDR antibody  >15 publications with Neuropilin-1 (Paired T916) and KDR
 FLT1 antibody  >7 publications with Neuropilin-1 (Paired T916) and FLT1
 PLXNA1 antibody  >5 publications with Neuropilin-1 (Paired T916) and PLXNA1
 SEMA3C antibody  >4 publications with Neuropilin-1 (Paired T916) and SEMA3C
 GIPC1 antibody  >3 publications with Neuropilin-1 (Paired T916) and GIPC1
 SEMA3B antibody  >3 publications with Neuropilin-1 (Paired T916) and SEMA3B
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 L1CAM Interactions Pathway antibodies  L1CAM Interactions Pathway Diagram
 Neurophilin Interactions With VEGF And VEGFR Pathway antibodies  Neurophilin Interactions With VEGF And VEGFR Pathway Diagram
 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies  SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
Diseases associated with anti-Neuropilin-1 (Paired T916) antibodyOrgans/Tissues associated with anti-Neuropilin-1 (Paired T916) antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >49 publications with Neuropilin-1 (Paired T916) and Neoplasms
 Neovascularization, Pathologic Antibodies  >21 publications with Neuropilin-1 (Paired T916) and Neovascularization, Pathologic
 Carcinoma Antibodies  >21 publications with Neuropilin-1 (Paired T916) and Carcinoma
 Vascular Diseases Antibodies  >15 publications with Neuropilin-1 (Paired T916) and Vascular Diseases
 Central Nervous System Diseases Antibodies  >11 publications with Neuropilin-1 (Paired T916) and Central Nervous System Diseases
 Neuroectodermal Tumors Antibodies  >9 publications with Neuropilin-1 (Paired T916) and Neuroectodermal Tumors
 Male Urogenital Diseases Antibodies  >9 publications with Neuropilin-1 (Paired T916) and Male Urogenital Diseases
 Breast Neoplasms Antibodies  >9 publications with Neuropilin-1 (Paired T916) and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >8 publications with Neuropilin-1 (Paired T916) and Neoplasm Metastasis
 Inflammation Antibodies  >8 publications with Neuropilin-1 (Paired T916) and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >11 publications with Neuropilin-1 (Paired T916) and Muscle
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