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anti-NOTCH2 antibody :: Notch 2 Antibody

Scan QR to view Datasheet Catalog #    MBS855201
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Notch 2 (NOTCH2), Antibody

 Also Known As   

Notch 2 (Cleaved-Asp1733) Antibody

 Product Synonym Names    Motch B; NOTC2; NOTCH2; NTC2; Neurogenic locus notch homolog protein 2 precursor; hN2
 Product Gene Name   

anti-NOTCH2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102500
 3D Structure    ModBase 3D Structure for Q04721
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Notch 2 (cleaved-Asp1733) antibody detects endogenous levels of fragment of activated Notch 2 resulting from cleavage adjacent to Asp1733.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from human Notch 2.
 All Sites    Human: Asp1733
Mouse: Asp1732
Rat: Asp1733
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-NOTCH2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NOTCH2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-NOTCH2 antibody    WB: 1:300~1:1000
IHC: 1:50~1:100
ELISA: 1:40000
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 Immunohistochemistry (IHC) of anti-NOTCH2 antibody    Cl-peptide-+ Immunohistochemical analysis of paraffin-embedded human brain tissue using Notch 2 (cleaved-Asp1733) antibody.
anti-NOTCH2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-NOTCH2 antibody    Western blot analysis of extracts from 293 cells treated with TNF-a (20ng/ml, 30mins), using Notch 2 (cleaved-Asp1733) antibody.
anti-NOTCH2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for NOTCH2. It may not necessarily be applicable to this product.
 NCBI GI #    317008611
 NCBI GeneID    4853
 NCBI Accession #    NP_001186930.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001200001.1 [Other Products]
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 UniProt Primary Accession #    Q04721 [Other Products]
 UniProt Secondary Accession #    Q5T3X7; Q99734; Q9H240 [Other Products]
 UniProt Related Accession #    Q04721 [Other Products]
 Molecular Weight    265,405 Da
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 NCBI Official Full Name    neurogenic locus notch homolog protein 2 isoform 2
 NCBI Official Synonym Full Names    notch 2
 NCBI Official Symbol    NOTCH2 [Similar Products]
 NCBI Official Synonym Symbols   
hN2; AGS2; HJCYS
[Similar Products]
 NCBI Protein Information    neurogenic locus notch homolog protein 2
 UniProt Protein Name    Neurogenic locus notch homolog protein 2
 Protein Family    Neurogenic locus notch homolog protein
 UniProt Gene Name    NOTCH2 [Similar Products]
 UniProt Synonym Gene Names    N2ICD [Similar Products]
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 NCBI Summary for NOTCH2    This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
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 UniProt Comments for NOTCH2    Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
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Product References and Citations for anti-NOTCH2 antibody

   R. Agarwal, Invest. Ophthalmol. Vis. Sci., May 2003; 44: 3340. Kohshi Ohishi, Blood, May 2000; 95: 2847-2854. T. Hayashi, J Androl, Nov 2001; 22: 999. TA Mitsiadis, J. Cell Biol., Jul 1995; 130: 407.
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 Research Articles on NOTCH2    1. Notch2 is important in Club cell differentiation in normal lungs and adenocarcinoma. Notch2 is regulated mutually with Notch1, and the balance of the expression of Notch receptors could determine the biological behaviours of lung cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NOTCH2 antibodyPathways associated with anti-NOTCH2 antibody
 Reference Product  PubMed Publications
 JAG1 antibody  >42 publications with NOTCH2 and JAG1
 DLL1 antibody  >31 publications with NOTCH2 and DLL1
 RBPJ antibody  >26 publications with NOTCH2 and RBPJ
 JAG2 antibody  >24 publications with NOTCH2 and JAG2
 LFNG antibody  >11 publications with NOTCH2 and LFNG
 MAML1 antibody  >9 publications with NOTCH2 and MAML1
 MFNG antibody  >6 publications with NOTCH2 and MFNG
 DTX1 antibody  >5 publications with NOTCH2 and DTX1
 PSEN2 antibody  >3 publications with NOTCH2 and PSEN2
 PSEN1 antibody  >3 publications with NOTCH2 and PSEN1
 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with anti-NOTCH2 antibodyOrgans/Tissues associated with anti-NOTCH2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >180 publications with NOTCH2 and Neoplasms
 Alagille Syndrome Antibodies  >33 publications with NOTCH2 and Alagille Syndrome
 Liver Diseases Antibodies  >26 publications with NOTCH2 and Liver Diseases
 Adenocarcinoma Antibodies  >25 publications with NOTCH2 and Adenocarcinoma
 Diabetes Mellitus, Type 2 Antibodies  >22 publications with NOTCH2 and Diabetes Mellitus, Type 2
 Cell Transformation, Neoplastic Antibodies  >21 publications with NOTCH2 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >21 publications with NOTCH2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >16 publications with NOTCH2 and Neoplasms, Experimental
 Hajdu-Cheney Syndrome Antibodies  >15 publications with NOTCH2 and Hajdu-Cheney Syndrome
 Kidney Diseases Antibodies  >14 publications with NOTCH2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >112 publications with NOTCH2 and Blood
 Bone Antibodies  >77 publications with NOTCH2 and Bone
 Brain Antibodies  >68 publications with NOTCH2 and Brain
 Embryonic Tissue Antibodies  >67 publications with NOTCH2 and Embryonic Tissue
 Liver Antibodies  >54 publications with NOTCH2 and Liver
 Bone Marrow Antibodies  >41 publications with NOTCH2 and Bone Marrow
 Vascular Antibodies  >38 publications with NOTCH2 and Vascular
 Kidney Antibodies  >37 publications with NOTCH2 and Kidney
 Nerve Antibodies  >31 publications with NOTCH2 and Nerve
 Muscle Antibodies  >30 publications with NOTCH2 and Muscle
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