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anti-Notch3 antibody :: anti-Human, Rat Notch 3 Antibody

Scan QR to view Datasheet Catalog #    MBS555219
Testing Data
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Notch 3 (Notch3), Antibody

 Also Known As   

Notch 3, Affinity Purified Antibody, Rabbit

 Product Gene Name   

anti-Notch3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125310
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 Species Reactivity    Human, Rat
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 Form/Format    Affinity Purified - Liquid
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 Type Info    Rabbit IgG
 Immunogen    Synthetic peptide representing the C terminal region of the human NOTCH homolog 3 (NOTCH1) protein.
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 Other Notes    Small volumes of anti-Notch3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Notch3 antibody

   The Notch protein sits like a trigger penetrating the cell membrane, with part of it inside and part outside. Proteins when binding to the exterior part cause the release of a portion of the interior part, which typically then makes its way to the cell nucleus to alter gene expression. The Notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine rich EGF like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1,Notch2, Notch3 and Notch4(Int3), which have been implicated in the differentiation of the nervous system and other structures. The EGF like proteins Delta and Serrate have been identified as ligands of Notch1.
 Product Categories/Family for anti-Notch3 antibody    Antibodies; Stem Cell Research Antibodies; Notch3
 Applications Tested/Suitable for anti-Notch3 antibody   

Immunohistochemistry (IHC), Western Blot (WB)

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 Testing Data of anti-Notch3 antibody    Image: Notch3 staining of rat cerebellum (Bergmann glia-10 micron cryostat sections). Working dilution is 1:100-1:300. Stained tissue was mounted under i-Brite Plus mounting media
anti-Notch3 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for Notch3. It may not necessarily be applicable to this product.
 NCBI GI #    3108187
 NCBI GeneID    4854
 NCBI Accession #    AAC15789.1 [Other Products]
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 UniProt Secondary Accession #    Q9UEB3; Q9UPL3; Q9Y6L8 [Other Products]
 UniProt Related Accession #    Q9UM47 [Other Products]
 Molecular Weight    243,631 Da
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 NCBI Official Full Name    Notch 3, partial
 NCBI Official Synonym Full Names    notch 3
 NCBI Official Symbol    NOTCH3 [Similar Products]
 NCBI Official Synonym Symbols   
IMF2; LMNS; CASIL; CADASIL; CADASIL1
[Similar Products]
 NCBI Protein Information    neurogenic locus notch homolog protein 3
 UniProt Protein Name    Neurogenic locus notch homolog protein 3
 Protein Family    Neurogenic locus notch homolog protein
 UniProt Gene Name    NOTCH3 [Similar Products]
 UniProt Synonym Gene Names    Notch 3 [Similar Products]
 UniProt Entry Name    NOTC3_HUMAN
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 UniProt Comments for Notch3    NOTCH3: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Heterodimer of a C-terminal fragment N(TM) and a N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN. Ubiquitously expressed in fetal and adult tissues. Belongs to the NOTCH family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.2-p13.1

Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; endoplasmic reticulum membrane; extracellular region; Golgi membrane; nucleoplasm; plasma membrane; receptor complex

Molecular Function: protein binding

Biological Process: Notch receptor processing; Notch signaling pathway; transcription initiation from RNA polymerase II promoter

Disease: Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy; Lateral Meningocele Syndrome; Myofibromatosis, Infantile, 2
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Notch3 antibodyPathways associated with anti-Notch3 antibody
 Reference Product  PubMed Publications
 JAG1 antibody  >118 publications with Notch3 and JAG1
 DLL1 antibody  >23 publications with Notch3 and DLL1
 RBPJ antibody  >18 publications with Notch3 and RBPJ
 NUMB antibody  >8 publications with Notch3 and NUMB
 PSEN1 antibody  >4 publications with Notch3 and PSEN1
 LFNG antibody  >3 publications with Notch3 and LFNG
 ADAM10 antibody  >3 publications with Notch3 and ADAM10
 PSEN2 antibody  >3 publications with Notch3 and PSEN2
 Products by Pathway  Pathway Diagram
 Defective LFNG Causes SCDO3 Pathway antibodies  Defective LFNG Causes SCDO3 Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With O-glycosylation Of Proteins Pathway antibodies  Diseases Associated With O-glycosylation Of Proteins Pathway Diagram
 Diseases Of Glycosylation Pathway antibodies  Diseases Of Glycosylation Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Dorso-ventral Axis Formation Pathway antibodies  Dorso-ventral Axis Formation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
Diseases associated with anti-Notch3 antibodyOrgans/Tissues associated with anti-Notch3 antibody
 Disease Name  Pubmed Publications
 CADASIL Antibodies  >502 publications with Notch3 and CADASIL
 Cardiovascular Diseases Antibodies  >490 publications with Notch3 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >65 publications with Notch3 and Disease Models, Animal
 Breast Neoplasms Antibodies  >41 publications with Notch3 and Breast Neoplasms
 Fibrosis Antibodies  >31 publications with Notch3 and Fibrosis
 Inflammation Antibodies  >29 publications with Notch3 and Inflammation
 Lung Neoplasms Antibodies  >29 publications with Notch3 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >25 publications with Notch3 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >23 publications with Notch3 and Neoplasm Metastasis
 Cognition Disorders Antibodies  >23 publications with Notch3 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >344 publications with Notch3 and Vascular
 Brain Antibodies  >300 publications with Notch3 and Brain
 Skin Antibodies  >90 publications with Notch3 and Skin
 Lung Antibodies  >70 publications with Notch3 and Lung
 Nerve Antibodies  >51 publications with Notch3 and Nerve
 Embryonic Tissue Antibodies  >47 publications with Notch3 and Embryonic Tissue
 Liver Antibodies  >39 publications with Notch3 and Liver
 Bone Antibodies  >38 publications with Notch3 and Bone
 Ganglia Antibodies  >36 publications with Notch3 and Ganglia
 Heart Antibodies  >30 publications with Notch3 and Heart
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