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anti-OCT-2 antibody :: Rabbit OCT-2 Antibody

Scan QR to view Datasheet Catalog #    MBS462094
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

OCT-2, Antibody

 Also Known As   

Rabbit anti OCT-2 antibody

 Product Synonym Names    Rabbit anti-Oct-2; POU2F2
 Product Gene Name   

anti-OCT-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (42592650..42636630, complement). Location: 19q13.2
 OMIM    164176
 3D Structure    ModBase 3D Structure for P09086
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    This antibody recognizes ~55 kDa of OCT-2 protein from human, rat and mouse origins. It does not cross react with OCT-1, OCT-4. The other species are not tested
 Purity/Purification    The Rabbit IgG is purified by Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide corresponding to C-terminus of OCT-1 protein from human, mouse and rat origins.
 Positive Control    Jurkat Cell Lysate
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C -8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-OCT-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-OCT-2 antibody

   Oct1 and Oct2 are transcription factors of the POU homeo-domain family that bind to the Ig gene octamer sites, regulating Bcell-specific genes. The function of these transcription factors is dependent on the activity of B-cell-restricted coactivators such as BOB.1/OBF.1.Absence of functional Oct-2 and Bob-1 cells represents a novel mechanism for immunoglobulin gene deregulation
 Applications Tested/Suitable for anti-OCT-2 antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-OCT-2 antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml
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 Testing Data of anti-OCT-2 antibody    anti-OCT-2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for OCT-2. It may not necessarily be applicable to this product.
 NCBI GI #    4379032
 NCBI GeneID    5452
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 UniProt Primary Accession #    P09086 [Other Products]
 UniProt Secondary Accession #    Q16648; Q7M4M8; Q9BRS4 [Other Products]
 UniProt Related Accession #    P09086; Q16624; Q9UMI6; Q9UMJ4 [Other Products]
 Molecular Weight    55 kDa
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 NCBI Official Full Name    Oct-2
 NCBI Official Synonym Full Names    POU class 2 homeobox 2
 NCBI Official Symbol    POU2F2 [Similar Products]
 NCBI Official Synonym Symbols   
OCT2; OTF2; Oct-2
[Similar Products]
 NCBI Protein Information    POU domain, class 2, transcription factor 2; OTF-2; homeobox protein; OTTHUMP00000231645; OTTHUMP00000231646; OTTHUMP00000231647; OTTHUMP00000231648; OTTHUMP00000231650; octamer-binding protein 2; octamer-binding transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2
 UniProt Protein Name    POU domain, class 2, transcription factor 2
 UniProt Synonym Protein Names   
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2
 UniProt Gene Name    POU2F2 [Similar Products]
 UniProt Synonym Gene Names    OCT2; OTF2 [Similar Products]
 UniProt Entry Name    PO2F2_HUMAN
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 NCBI Summary for OCT-2    The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for OCT-2    Function: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Ref.2 Ref.6 Ref.8 Ref.9

Subunit structure: Interacts with NR3C1, AR and PGR. Ref.11

Subcellular location: Cytoplasm

By similarity. Nucleus.

Tissue specificity: Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line Molt-4, but not in the T-cell line BW 5147. Ref.2 Ref.10

Sequence similarities: Belongs to the POU transcription factor family. Class-2 subfamily.Contains 1 homeobox DNA-binding domain.Contains 1 POU-specific domain.

Sequence caution: The sequence CAA32039.1 differs from that shown. Reason: Erroneous initiation.
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Product References and Citations for anti-OCT-2 antibody

   Daniel Re, et al. Oct-2 and Bob-1 Deficiency in Hodgkin and Reed Sternberg Cells. Cancer Research 61, 2080-2084 (2001).
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 Research Articles on OCT-2    1. Twenty-two cases of nodular lymphocyte predominant Hodgkin lymphoma were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-OCT-2 antibodyPathways associated with anti-OCT-2 antibody
 Reference Product  PubMed Publications
 POU2AF1 antibody  >35 publications with OCT-2 and POU2AF1
 TBP antibody  >4 publications with OCT-2 and TBP
 HMGB2 antibody  >1 publications with OCT-2 and HMGB2
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
Diseases associated with anti-OCT-2 antibodyOrgans/Tissues associated with anti-OCT-2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >40 publications with OCT-2 and Neoplasms
 Hodgkin Disease Antibodies  >11 publications with OCT-2 and Hodgkin Disease
 Vascular Diseases Antibodies  >4 publications with OCT-2 and Vascular Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with OCT-2 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >3 publications with OCT-2 and Neoplasms, Experimental
 Melanoma Antibodies  >2 publications with OCT-2 and Melanoma
 Liver Neoplasms Antibodies  >1 publications with OCT-2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >1 publications with OCT-2 and Breast Neoplasms
 Genital Neoplasms, Female Antibodies  >1 publications with OCT-2 and Genital Neoplasms, Female
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >114 publications with OCT-2 and Blood
 Brain Antibodies  >20 publications with OCT-2 and Brain
 Lymph Node Antibodies  >7 publications with OCT-2 and Lymph Node
 Lymph Antibodies  >6 publications with OCT-2 and Lymph
 Bone Antibodies  >6 publications with OCT-2 and Bone
 Embryonic Tissue Antibodies  >3 publications with OCT-2 and Embryonic Tissue
 Liver Antibodies  >3 publications with OCT-2 and Liver
 Tonsil Antibodies  >2 publications with OCT-2 and Tonsil
 Testis Antibodies  >2 publications with OCT-2 and Testis
 Skin Antibodies  >2 publications with OCT-2 and Skin
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