NP_001177808.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,034 Da
NCBI Official Full Name
origin recognition complex subunit 4 isoform 1
NCBI Official Synonym Full Names
origin recognition complex subunit 4
NCBI Official Synonym Symbols
NCBI Protein Information
origin recognition complex subunit 4
UniProt Protein Name
Origin recognition complex subunit 4
UniProt Synonym Gene Names
NCBI Summary for ORC4L
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
UniProt Comments for ORC4L
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Research Articles on ORC4L
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Pathways associated with anti-ORC4L antibody
Diseases associated with anti-ORC4L antibody
Organs/Tissues associated with anti-ORC4L antibody
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