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ODC1 antibody :: Ornithine Decarboxylase-1 (ODC-1) Antibody

Scan QR to view Datasheet Catalog #    MBS438357
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ornithine Decarboxylase-1 (ODC-1) (ODC1), Antibody

 Also Known As   

Ornithine Decarboxylase-1 (ODC-1) Mouse Monoclonal Antibody

 Product Synonym Names    Ornithine decarboxylase structural 1; RNODC
 Product Gene Name   

ODC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    165640
 3D Structure    ModBase 3D Structure for P11926
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    SPM565
 Host    Mouse
 Species Reactivity    Human, Rat
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 Specificity    Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic
 Immunogen    Recombinant human ODC-1 protein
 Hu-Chromosome Location    2p25.1
 Positive Control    Epithelial cells in normal placenta or prostate carcinoma.
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of ODC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ODC1 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for ODC1 antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (0.5-1ug/ml)
Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of ODC1 antibody    Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with ODC-1 Monoclonal Antibody (SPM565)
ODC1 antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ODC1. It may not necessarily be applicable to this product.
 NCBI GI #    563580287
 NCBI GeneID    4953
 NCBI Accession #    NP_001274118.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001287189.1 [Other Products]
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 UniProt Primary Accession #    P11926 [Other Products]
 UniProt Secondary Accession #    Q53TU3; Q6LDS9 [Other Products]
 UniProt Related Accession #    P11926 [Other Products]
 Molecular Weight    53kDa
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 NCBI Official Full Name    ornithine decarboxylase isoform 1
 NCBI Official Synonym Full Names    ornithine decarboxylase 1
 NCBI Official Symbol    ODC1 [Similar Products]
 NCBI Official Synonym Symbols   
ODC
[Similar Products]
 NCBI Protein Information    ornithine decarboxylase
 UniProt Protein Name    Ornithine decarboxylase
 Protein Family    Mitochondrial 2-oxodicarboxylate carrier
 UniProt Gene Name    ODC1 [Similar Products]
 UniProt Synonym Gene Names    ODC [Similar Products]
 UniProt Entry Name    DCOR_HUMAN
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 NCBI Summary for ODC1    This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
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 UniProt Comments for ODC1    ODC: the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]

Protein type: Lyase; Amino Acid Metabolism - arginine and proline; EC 4.1.1.17; Other Amino Acids Metabolism - glutathione; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: cytoplasm; cytosol

Molecular Function: ornithine decarboxylase activity; protein binding; protein homodimerization activity

Biological Process: polyamine metabolic process; putrescine biosynthetic process from ornithine; regulation of amino acid metabolic process; regulation of protein catabolic process; response to virus

Disease: Colorectal Cancer
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Product References and Citations for ODC1 antibody

   Schipper RG; Rutten RG; Sauerbeck M; Schielen WJ; Adams PJ; Kopitz J; Bohley P; Tesser GI; Verhofstad AA. Preparation and characterization of monoclonal antibodies against ornithine decarboxylase. Journal of Immunological Methods, 1993, 161(2):205-15.
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 Research Articles on ODC1    1. We earlier presented evidence for a physical interaction between ODC and SPR and we showed that RNAi-mediated knockdown of SPR expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma cell proliferation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ODC1 antibody Diseases associated with ODC1 antibody
 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Metabolism Of Polyamines Pathway antibodies  Metabolism Of Polyamines Pathway Diagram
 Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway antibodies  Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway Diagram
 Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway antibodies  Polyamine Biosynthesis, Arginine => Ornithine => Putrescine Pathway Diagram
 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >5 publications with ODC1 and Colorectal Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with ODC1 and Neoplasms, Experimental
 Colonic Neoplasms Antibodies  >2 publications with ODC1 and Colonic Neoplasms
 Depressive Disorder Antibodies  >1 publications with ODC1 and Depressive Disorder
 Breast Neoplasms Antibodies  >1 publications with ODC1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with ODC1 and Lung Neoplasms
 Hypertension Antibodies  >1 publications with ODC1 and Hypertension
 Heart Diseases Antibodies  >1 publications with ODC1 and Heart Diseases
 Necrosis Antibodies  >1 publications with ODC1 and Necrosis
 HIV Infections Antibodies  >1 publications with ODC1 and HIV Infections
Organs/Tissues associated with ODC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >6 publications with ODC1 and Muscle
 Prostate Antibodies  >5 publications with ODC1 and Prostate
 Brain Antibodies  >5 publications with ODC1 and Brain
 Liver Antibodies  >4 publications with ODC1 and Liver
 Uterus Antibodies  >4 publications with ODC1 and Uterus
 Embryonic Tissue Antibodies  >4 publications with ODC1 and Embryonic Tissue
 Lung Antibodies  >3 publications with ODC1 and Lung
 Vascular Antibodies  >3 publications with ODC1 and Vascular
 Blood Antibodies  >3 publications with ODC1 and Blood
 Ovary Antibodies  >3 publications with ODC1 and Ovary
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