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anti-PAK7 antibody :: PAK7 Antibody

Scan QR to view Datasheet Catalog #    MBS855963
Testing Data #3
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PAK7, Antibody

★Popular Item★
 Also Known As   

PAK7 Antibody

 Product Synonym Names    KIAA1264; p21-activated kinase 7; PAK 7; PAK-5; PAK-7; PAK5; PAK7
 Product Gene Name   

anti-PAK7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608038
 3D Structure    ModBase 3D Structure for Q9P286
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    PAK7 antibody detects endogenous levels of total PAK7 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from C-terminal of human PAK7.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-PAK7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-PAK7 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-PAK7 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-PAK7 antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:40000
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 Testing Data #3 of anti-PAK7 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue, using PAK7 antibody.
Western blot analysis of extracts from rat brain cells, using PAK7 antibody.
anti-PAK7 antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for PAK7. It may not necessarily be applicable to this product.
 NCBI GI #    24308191
 NCBI GeneID    57144
 NCBI Accession #    NP_065074.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020341.3 [Other Products]
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 UniProt Primary Accession #    Q9P286 [Other Products]
 UniProt Secondary Accession #    Q5W115; Q8TB93; Q9BX09; Q9ULF6; A8K5T6; D3DW14 [Other Products]
 UniProt Related Accession #    Q9P286 [Other Products]
 Molecular Weight    80,745 Da
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 NCBI Official Full Name    serine/threonine-protein kinase PAK 5
 NCBI Official Synonym Full Names    p21 (RAC1) activated kinase 5
 NCBI Official Symbol    PAK5 [Similar Products]
 NCBI Official Synonym Symbols   
PAK7
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase PAK 5
 UniProt Protein Name    Serine/threonine-protein kinase PAK 5
 UniProt Synonym Protein Names   
p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7
 UniProt Gene Name    PAK5 [Similar Products]
 UniProt Synonym Gene Names    PAK-5; PAK-7 [Similar Products]
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 NCBI Summary for PAK7    The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PAK7    Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
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Product References and Citations for anti-PAK7 antibody

   Pandey A., Oncogene 21:3939-3948(2002). Nagase T., DNA Res. 6:337-345(1999). Deloukas P., Nature 414:865-871(2001).
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 Research Articles on PAK7    1. p21-activated kinase (PAK7) was identified as the putative target of miR492 in osteosarcoma (OS), and we further found a significantly inverse correlation between PAK7 and miR492 in OS specimens.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PAK7 antibodyPathways associated with anti-PAK7 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >13 publications with PAK7 and CDC42
 RAC1 antibody  >4 publications with PAK7 and RAC1
 BAD antibody  >2 publications with PAK7 and BAD
 Products by Pathway  Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-PAK7 antibodyOrgans/Tissues associated with anti-PAK7 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with PAK7 and Neoplasms
 Nervous System Diseases Antibodies  >2 publications with PAK7 and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >1 publications with PAK7 and Peripheral Nervous System Diseases
 Anemia Antibodies  >1 publications with PAK7 and Anemia
 Melanoma Antibodies  >1 publications with PAK7 and Melanoma
 Learning Disorders Antibodies  >1 publications with PAK7 and Learning Disorders
 Hypertension Antibodies  >1 publications with PAK7 and Hypertension
 Vascular Diseases Antibodies  >1 publications with PAK7 and Vascular Diseases
 Pain Antibodies  >1 publications with PAK7 and Pain
 Inflammation Antibodies  >1 publications with PAK7 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with PAK7 and Brain
 Pancreas Antibodies  >2 publications with PAK7 and Pancreas
 Embryonic Tissue Antibodies  >2 publications with PAK7 and Embryonic Tissue
 Mouth Antibodies  >1 publications with PAK7 and Mouth
 Eye Antibodies  >1 publications with PAK7 and Eye
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