Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow PARP  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • pro-platelet basic protein (PPBP) Antibody
 • cadherin 4, type 1, R-cadherin (retinal) (CDH4) ELISA Kit
 • C-C chemokine receptor type 9 (CCR9) ELISA Kit
 • Annexin A10-Annexin 14 (ANXA10) Antibody
 • free thyroxine (FT4) ELISA Kit
 • D-galactose-binding periplasmic protein (mglB) Recombinant Protein
 • BAFFR ELISA Kit
 • Norovirus VP1 Antibody
 • CRTAM Antibody
 • Complement 1 Inhibitor (C1INH) ELISA Kit
 • CD44v10 Antibody
 • Clumping factor A (clfA), partial Recombinant Protein
 • Adrenocorticotropic Hormone receptor (ACTHR) ELISA Kit
 • beta Endorphin (beta-EP) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-PARP antibody :: Mouse anti-Human PARP Antibody

Scan QR to view Datasheet Catalog #    MBS850008
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PARP, Antibody

 Also Known As   

PARP Antibody

 Product Synonym Names    PARP; PPOL; ADPRT; ADPRT1; PARP-1; pADPRT-1; PARP1
 Product Gene Name   

anti-PARP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    173870
 3D Structure    ModBase 3D Structure for P09874
Section Bar
 Isotype    IgG1
 Clone Number    7A10
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Form/Format    Ascitic fluid containing 0.03% sodium azide.
Section Bar
 Immunogen    Synthetic peptide of human PARP, conjugated to KLH.
Section Bar
 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C.
 Other Notes    Small volumes of anti-PARP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-PARP antibody

   This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
 Product Categories/Family for anti-PARP antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-PARP antibody   

Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)

 Application Notes for anti-PARP antibody    WB: 1:500-1:2000
FC: 1:200-1:400
ELISA: 1:10000
Section Bar
 Western Blot (WB) of anti-PARP antibody    Figure 1: Western blot analysis using PARP mouse mAb against Jurkat (1), K562 (2), Hela (3), Raji (4), THP-1 (5) and SW620 (6) cell lysate.
anti-PARP antibody Western Blot (WB) (WB) image
Section Bar
 Flow Cytometry (FC/FACS) of anti-PARP antibody    Figure 2: Flow cytometric analysis of Jurkat cells using anti-PARP mAb (green) and negative control (purple).
anti-PARP antibody Flow Cytometry (FC/FACS) (FC/FACS) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PARP. It may not necessarily be applicable to this product.
 NCBI GI #    156523968
 NCBI GeneID    142
 NCBI Accession #    NP_001609.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001618.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P09874 [Other Products]
 UniProt Secondary Accession #    Q8IUZ9; B1ANJ4 [Other Products]
 UniProt Related Accession #    P09874 [Other Products]
 Molecular Weight    117kDa
Table BarTOPTable Bar
 NCBI Official Full Name    poly
 NCBI Official Synonym Full Names    poly(ADP-ribose) polymerase 1
 NCBI Official Symbol    PARP1 [Similar Products]
 NCBI Official Synonym Symbols   
PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
[Similar Products]
 NCBI Protein Information    poly [ADP-ribose] polymerase 1
 UniProt Protein Name    Poly [ADP-ribose] polymerase 1
 UniProt Synonym Protein Names   
ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1
 Protein Family    PARP-type zinc finger-containing protein
 UniProt Gene Name    PARP1 [Similar Products]
 UniProt Synonym Gene Names    ADPRT; PPOL; PARP-1; ARTD1; ADPRT 1 [Similar Products]
Section Bar
 NCBI Summary for PARP    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for PARP    Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). Mediates the poly(ADP-ribosyl)ation of histones in a HPF1-dependent manner (PubMed:27067600). Involved in the synthesis of ATP in the nucleus, together with NMNAT1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).
Table BarTOPTable Bar
 Research Articles on PARP    1. The phosphorylation level of p38 was upregulated by MA1 treatment, and the inhibitor of p38, SB203580, attenuated the MA1-induced p38 phosphorylation as well as caspase3 and PARP activation. These results indicate that MA1 treatment alters invasive and oncogenic phenotypes of human colorectal cancer cells through the stimulation of the p38 signaling pathway
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-PARP antibodyPathways associated with anti-PARP antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >229 publications with PARP and CASP3
 XRCC1 antibody  >63 publications with PARP and XRCC1
 PARP2 antibody  >56 publications with PARP and PARP2
 CASP7 antibody  >31 publications with PARP and CASP7
 PRKDC antibody  >27 publications with PARP and PRKDC
 TP53 antibody  >25 publications with PARP and TP53
 CDKN1A antibody  >20 publications with PARP and CDKN1A
 PCNA antibody  >18 publications with PARP and PCNA
 BCL2 antibody  >14 publications with PARP and BCL2
 PARP3 antibody  >12 publications with PARP and PARP3
 Products by Pathway  Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 BER Complex Pathway antibodies  BER Complex Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
Diseases associated with anti-PARP antibodyOrgans/Tissues associated with anti-PARP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >442 publications with PARP and Neoplasms
 Necrosis Antibodies  >122 publications with PARP and Necrosis
 Breast Neoplasms Antibodies  >121 publications with PARP and Breast Neoplasms
 Drug Toxicity Antibodies  >88 publications with PARP and Drug Toxicity
 Nervous System Diseases Antibodies  >85 publications with PARP and Nervous System Diseases
 Inflammation Antibodies  >78 publications with PARP and Inflammation
 Ovarian Neoplasms Antibodies  >38 publications with PARP and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >36 publications with PARP and Lung Neoplasms
 Liver Diseases Antibodies  >31 publications with PARP and Liver Diseases
 Neoplasms, Experimental Antibodies  >30 publications with PARP and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >112 publications with PARP and Blood
 Brain Antibodies  >81 publications with PARP and Brain
 Lung Antibodies  >69 publications with PARP and Lung
 Liver Antibodies  >53 publications with PARP and Liver
 Vascular Antibodies  >40 publications with PARP and Vascular
 Skin Antibodies  >35 publications with PARP and Skin
 Muscle Antibodies  >35 publications with PARP and Muscle
 Kidney Antibodies  >32 publications with PARP and Kidney
 Prostate Antibodies  >27 publications with PARP and Prostate
 Nerve Antibodies  >24 publications with PARP and Nerve
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions