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anti-PECAM1 antibody :: Rabbit PECAM1 Antibody

Scan QR to view Datasheet Catalog #    MBS8501612
Unit / Price
0.1 mL  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PECAM1, Antibody

★Popular Item★
 Also Known As   

PECAM1 Antibody

 Product Synonym Names    CD31; PECA1; GPIIA'; PECAM-1; endoCAM
 Product Gene Name   

anti-PECAM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    173445
 3D Structure    ModBase 3D Structure for P16284
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
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 Immunogen    A synthetic peptide of human PECAM1
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-PECAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PECAM1 antibody

   The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
 Product Categories/Family for anti-PECAM1 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-PECAM1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-PECAM1 antibody    WB: 1:500-1:2000
IHC: 1:25-1:100
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 Western Blot (WB) of anti-PECAM1 antibody    Western blot analysis of extracts of variousJurkatcell line, using PECAM1antibody.
anti-PECAM1 antibody Western Blot (WB) (WB) image
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 Testing Data of anti-PECAM1 antibody    anti-PECAM1 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-PECAM1 antibody    Immunohistochemistryof paraffin-embeddedhuman colon cancer tissue usingPECAM1antibody.
anti-PECAM1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for PECAM1. It may not necessarily be applicable to this product.
 NCBI GI #    313760624
 NCBI GeneID    5175
 NCBI Accession #    NP_000433.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_000442.4 [Other Products]
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 UniProt Primary Accession #    P16284 [Other Products]
 UniProt Secondary Accession #    Q6LDA9; Q8TBH1; Q96RF5; Q96RF6; Q9NP65; Q9NPB7; Q9NPG9; A0A075B738; A8K3S7; D3DU31 [Other Products]
 UniProt Related Accession #    P16284 [Other Products]
 Molecular Weight    83kDa
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 NCBI Official Full Name    platelet endothelial cell adhesion molecule
 NCBI Official Synonym Full Names    platelet and endothelial cell adhesion molecule 1
 NCBI Official Symbol    PECAM1 [Similar Products]
 NCBI Official Synonym Symbols   
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
[Similar Products]
 NCBI Protein Information    platelet endothelial cell adhesion molecule
 UniProt Protein Name    Platelet endothelial cell adhesion molecule
 UniProt Synonym Protein Names   
EndoCAM; GPIIA'; PECA1; CD_antigen: CD31
 Protein Family    Platelet endothelial cell adhesion molecule
 UniProt Gene Name    PECAM1 [Similar Products]
 UniProt Synonym Gene Names    PECAM-1 [Similar Products]
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 NCBI Summary for PECAM1    The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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 UniProt Comments for PECAM1    Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis ().
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 Research Articles on PECAM1    1. In primary hip OA, angiogenesis may be induced by a combined mechanism: hypoxia-related VEGF-dependent vasculogenesis and endothelial differentiation of the activated pluripotent cells, which are released from the hyperplastic synovial cells layer. An endothelial mesenchymal transition is assumed to be involved in the fibrotic process.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PECAM1 antibodyPathways associated with anti-PECAM1 antibody
 Reference Product  PubMed Publications
 CD38 antibody  >63 publications with PECAM1 and CD38
 SRC antibody  >58 publications with PECAM1 and SRC
 CTNNB1 antibody  >42 publications with PECAM1 and CTNNB1
 PTPN11 antibody  >33 publications with PECAM1 and PTPN11
 PTPN6 antibody  >17 publications with PECAM1 and PTPN6
 CSK antibody  >6 publications with PECAM1 and CSK
 FYN antibody  >5 publications with PECAM1 and FYN
 ITGB3 antibody  >4 publications with PECAM1 and ITGB3
 LYN antibody  >3 publications with PECAM1 and LYN
 JUP antibody  >3 publications with PECAM1 and JUP
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PECAM1 Interactions Pathway antibodies  PECAM1 Interactions Pathway Diagram
Diseases associated with anti-PECAM1 antibodyOrgans/Tissues associated with anti-PECAM1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1570 publications with PECAM1 and Neoplasms
 Inflammation Antibodies  >443 publications with PECAM1 and Inflammation
 Necrosis Antibodies  >373 publications with PECAM1 and Necrosis
 Neoplasms, Experimental Antibodies  >235 publications with PECAM1 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >228 publications with PECAM1 and Neoplasm Metastasis
 Lung Diseases Antibodies  >211 publications with PECAM1 and Lung Diseases
 Heart Diseases Antibodies  >210 publications with PECAM1 and Heart Diseases
 Breast Neoplasms Antibodies  >187 publications with PECAM1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >164 publications with PECAM1 and Lung Neoplasms
 Liver Diseases Antibodies  >149 publications with PECAM1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3069 publications with PECAM1 and Vascular
 Blood Antibodies  >2726 publications with PECAM1 and Blood
 Muscle Antibodies  >607 publications with PECAM1 and Muscle
 Bone Marrow Antibodies  >397 publications with PECAM1 and Bone Marrow
 Lung Antibodies  >384 publications with PECAM1 and Lung
 Heart Antibodies  >313 publications with PECAM1 and Heart
 Brain Antibodies  >289 publications with PECAM1 and Brain
 Liver Antibodies  >270 publications with PECAM1 and Liver
 Umbilical Cord Antibodies  >216 publications with PECAM1 and Umbilical Cord
 Kidney Antibodies  >215 publications with PECAM1 and Kidney
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