NP_004827.4
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2 alpha kinase 3
NCBI Protein Information
eukaryotic translation initiation factor 2-alpha kinase 3
UniProt Protein Name
Eukaryotic translation initiation factor 2-alpha kinase 3
UniProt Synonym Protein Names
PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; HsPEK
UniProt Synonym Gene Names
NCBI Summary for PEK/PERK
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]
UniProt Comments for PEK/PERK
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Product References and Citations for anti-PEK/PERK antibody
Shi Y., An J., J. Biol. Chem. 274:5723-5730(1999). Sood R., Biochem. J. 346:281-293(2000). The MGC Project Team; Genome Res. 14:2121-2127(2004).
Research Articles on PEK/PERK
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-PEK/PERK antibody
Pathways associated with anti-PEK/PERK antibody
Diseases associated with anti-PEK/PERK antibody
Organs/Tissues associated with anti-PEK/PERK antibody
|