AAH42578.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,208 Da
NCBI Official Full Name
PGC protein
NCBI Official Synonym Full Names
progastricsin
NCBI Official Synonym Symbols
NCBI Protein Information
gastricsin
UniProt Protein Name
Gastricsin
UniProt Synonym Protein Names
Pepsinogen C
NCBI Summary for PGC
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
UniProt Comments for PGC
Hydrolyzes a variety of proteins.
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Products associated with anti-PGC antibody
Diseases associated with anti-PGC antibody
Organs/Tissues associated with anti-PGC antibody
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