NP_002622.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,140 Da
NCBI Official Full Name
6-phosphogluconate dehydrogenase, decarboxylating
NCBI Official Synonym Full Names
phosphogluconate dehydrogenase
NCBI Official Synonym Symbols
NCBI Protein Information
6-phosphogluconate dehydrogenase, decarboxylating
UniProt Protein Name
6-phosphogluconate dehydrogenase, decarboxylating
UniProt Synonym Gene Names
UniProt Entry Name
6PGD_HUMAN
NCBI Summary for PGD
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq, Jul 2008]
UniProt Comments for PGD
PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways.
Protein type: Oxidoreductase; Carbohydrate Metabolism - pentose phosphate pathway; Other Amino Acids Metabolism - glutathione; EC 1.1.1.44
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: nucleus; cytosol
Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity; NADP binding
Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; carbohydrate metabolic process; pathogenesis; D-gluconate metabolic process; pentose biosynthetic process
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Pathways associated with anti-PGD antibody
Diseases associated with anti-PGD antibody
Organs/Tissues associated with anti-PGD antibody
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