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UCHL1 antibody :: PGP9.5 / UchL1 Antibody

Scan QR to view Datasheet Catalog #    MBS438304
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PGP9.5 / UchL1, Antibody

★Popular Item★
 Also Known As   

PGP9.5 / UchL1 (pan-Neuronal Marker) Mouse Monoclonal Antibody

 Product Synonym Names    Gracile Axonal Dystrophy; Neuron Cytoplasmic Protein 9.5; Park5; Parkinson Disease 5; PGP95; Protein Gene Product 9.5; Ubiquitin Carboxyl-terminal Esterase L1; Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1; Ubiquitin Thioesterase L1; Ubiquitin Thiolesterase L1
 Product Gene Name   

UCHL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    191342
 3D Structure    ModBase 3D Structure for P09936
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    SPM574
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Cow, Pig
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 Specificity    This MAb reacts with a protein of 20-30kDa, identified as PGP9.5, also known as ubiquitin carboxyl-terminal hydrolase-1 (UchL1). Initially, PGP9.5 expression in normal tissues was reported in neurons and neuroendocrine cells but later it was found in distal renal tubular epithelium, spermatogonia, Leydig cells, oocytes, melanocytes, prostatic secretory epithelium, ejaculatory duct cells, epididymis, mammary epithelial cells, Merkel cells, and dermal fibroblasts. Furthermore, immunostaining for PGP9.5 has been shown in a wide variety of mesenchymal neoplasms as well. A mutation in PGP9.5 gene is believed to cause a form of Parkinson's disease.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic. Endoplasmic Reticulum membrane
 Immunogen    Native UchL1 (PGP9.5) protein from brain
 Hu-Chromosome Location    4p13
 Positive Control    Cerebellum
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C. Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of UCHL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for UCHL1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for UCHL1 antibody    Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of UCHL1 antibody    Formalin-fixed, paraffin-embedded Rat Cerebellum stained with Pgp9.5 / UchL1 Monoclonal Antibody (SPM574).
UCHL1 antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for UCHL1. It may not necessarily be applicable to this product.
 NCBI GI #    21361091
 NCBI GeneID    7345
 NCBI Accession #    NP_004172.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004181.4 [Other Products]
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 UniProt Primary Accession #    P09936 [Other Products]
 UniProt Secondary Accession #    Q4W5K6; Q71UM0 [Other Products]
 UniProt Related Accession #    P09936 [Other Products]
 Molecular Weight    20-30kDa
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase isozyme L1
 NCBI Official Synonym Full Names    ubiquitin C-terminal hydrolase L1
 NCBI Official Symbol    UCHL1 [Similar Products]
 NCBI Official Synonym Symbols   
NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase isozyme L1
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase isozyme L1
 UniProt Synonym Protein Names   
Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1
 Protein Family    Ubiquitin carboxyl-terminal hydrolase
 UniProt Gene Name    UCHL1 [Similar Products]
 UniProt Synonym Gene Names    UCH-L1; PGP9.5 [Similar Products]
 UniProt Entry Name    UCHL1_HUMAN
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 NCBI Summary for UCHL1    The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
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 UniProt Comments for UCHL1    UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family.

Protein type: Ubiquitin conjugating system; Cell development/differentiation; Protease; EC 3.4.19.12; Ligase

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: cytoplasm; nucleoplasm; plasma membrane

Molecular Function: alpha-2A adrenergic receptor binding; cysteine-type endopeptidase activity; omega peptidase activity; protein binding; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity

Biological Process: negative regulation of MAP kinase activity; protein deubiquitination; regulation of macroautophagy

Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant
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Product References and Citations for UCHL1 antibody

   Day IN et. al. Biochem Society Trans 14:350-351 (1986
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 Research Articles on UCHL1    1. Serum UCH-l1 levels serve as a novel biomarker for neuronal damage from white matter lesions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with UCHL1 antibody Pathways associated with UCHL1 antibody
 Reference Product  PubMed Publications
 SNCA antibody  >30 publications with UCHL1 and SNCA
 CDKN2A antibody  >4 publications with UCHL1 and CDKN2A
 TP53 antibody  >4 publications with UCHL1 and TP53
 HSP90AA1 antibody  >2 publications with UCHL1 and HSP90AA1
 COPS5 antibody  >1 publications with UCHL1 and COPS5
 HSPA8 antibody  >1 publications with UCHL1 and HSPA8
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Proteasome Degradation Pathway antibodies  Proteasome Degradation Pathway Diagram
Diseases associated with UCHL1 antibody Organs/Tissues associated with UCHL1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >245 publications with UCHL1 and Nervous System Diseases
 Brain Diseases Antibodies  >174 publications with UCHL1 and Brain Diseases
 Inflammation Antibodies  >48 publications with UCHL1 and Inflammation
 Disease Models, Animal Antibodies  >43 publications with UCHL1 and Disease Models, Animal
 Peripheral Nervous System Diseases Antibodies  >38 publications with UCHL1 and Peripheral Nervous System Diseases
 Cardiovascular Diseases Antibodies  >35 publications with UCHL1 and Cardiovascular Diseases
 Necrosis Antibodies  >25 publications with UCHL1 and Necrosis
 Nerve Degeneration Antibodies  >22 publications with UCHL1 and Nerve Degeneration
 Brain Injuries Antibodies  >19 publications with UCHL1 and Brain Injuries
 Lung Neoplasms Antibodies  >18 publications with UCHL1 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >221 publications with UCHL1 and Nerve
 Brain Antibodies  >144 publications with UCHL1 and Brain
 Skin Antibodies  >104 publications with UCHL1 and Skin
 Muscle Antibodies  >66 publications with UCHL1 and Muscle
 Lymph Antibodies  >66 publications with UCHL1 and Lymph
 Lymph Node Antibodies  >64 publications with UCHL1 and Lymph Node
 Bone Antibodies  >64 publications with UCHL1 and Bone
 Vascular Antibodies  >60 publications with UCHL1 and Vascular
 Lung Antibodies  >43 publications with UCHL1 and Lung
 Bone Marrow Antibodies  >37 publications with UCHL1 and Bone Marrow
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