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anti-PIP5K antibody :: Rabbit anti-Human, mouse PIP5K Antibody

Scan QR to view Datasheet Catalog #    MBS004269 anti-PIP5K antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PIP5K, Antibody

 Also Known As   

Rabbit PIP5K Antibody

 Product Gene Name   

anti-PIP5K antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (209130991..209223475). Location: 2q34
 OMIM    121850
 3D Structure    ModBase 3D Structure for Q9Y2I7
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-PIP5K antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PIP5K antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PIP5K. It may not necessarily be applicable to this product.
 NCBI GI #    295789162
 NCBI GeneID    200576
 NCBI Accession #    NP_001171471.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001178000.1 [Other Products]
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 UniProt Primary Accession #    Q9Y2I7 [Other Products]
 UniProt Secondary Accession #    Q08AR7; Q08AR8; Q53ST3; Q53T36; Q8N5H0; Q8NB67 [Other Products]
 UniProt Related Accession #    Q9Y2I7 [Other Products]
 Molecular Weight    237,136 Da
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 NCBI Official Full Name    1-phosphatidylinositol 3-phosphate 5-kinase isoform 4
 NCBI Official Synonym Full Names    phosphoinositide kinase, FYVE finger containing
 NCBI Official Symbol    PIKFYVE [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    1-phosphatidylinositol 3-phosphate 5-kinase; PIPkin-III; type III PIP kinase; zinc finger, FYVE domain containing 29; 1-phosphatidylinositol-3-phosphate 5-kinase; phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
 UniProt Protein Name    1-phosphatidylinositol 3-phosphate 5-kinase
 UniProt Synonym Protein Names   
FYVE finger-containing phosphoinositide kinase; PIKfyve; Phosphatidylinositol 3-phosphate 5-kinase type III
 UniProt Gene Name    PIKFYVE [Similar Products]
 UniProt Synonym Gene Names    KIAA0981; PIP5K3; Phosphatidylinositol 3-phosphate 5-kinase; PIPkin-III [Similar Products]
 UniProt Entry Name    FYV1_HUMAN
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 NCBI Summary for PIP5K    Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
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 UniProt Comments for PIP5K    PIKFYVE: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes. Defects in PIKFYVE are the cause of corneal fleck dystrophy (CFD). CFD is an autosomal dominant disorder of the cornea characterized by numerous small white flecks scattered in all levels of the stroma. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC; Carbohydrate Metabolism - inositol phosphate; Kinase, lipid

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: Golgi membrane; perinuclear region of cytoplasm; early endosome membrane; late endosome membrane; endosome membrane; intercellular junction; cytoplasmic vesicle; cytosol; lipid raft

Molecular Function: 1-phosphatidylinositol-3-phosphate 5-kinase activity; protein binding; 1-phosphatidylinositol-4-phosphate 5-kinase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; metal ion binding; ATP binding

Biological Process: myelin formation; receptor-mediated endocytosis; cellular protein metabolic process; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; retrograde transport, endosome to Golgi

Disease: Corneal Dystrophy, Fleck
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 Research Articles on PIP5K    1. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PIP5K antibodyDiseases associated with anti-PIP5K antibody
 Products by Pathway  Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 3-phosphoinositide Biosynthesis Pathway antibodies  3-phosphoinositide Biosynthesis Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >7 publications with PIP5K and Nervous System Diseases
 Congenital Abnormalities Antibodies  >5 publications with PIP5K and Congenital Abnormalities
 Corneal Dystrophy, Fleck Antibodies  >5 publications with PIP5K and Corneal Dystrophy, Fleck
 Nervous System Malformations Antibodies  >4 publications with PIP5K and Nervous System Malformations
 Neoplasms Antibodies  >3 publications with PIP5K and Neoplasms
 Nerve Degeneration Antibodies  >2 publications with PIP5K and Nerve Degeneration
 Cardiovascular Diseases Antibodies  >1 publications with PIP5K and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with PIP5K and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with PIP5K and Inflammation
 Heart Defects, Congenital Antibodies  >1 publications with PIP5K and Heart Defects, Congenital
Organs/Tissues associated with anti-PIP5K antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with PIP5K and Brain
 Intestine Antibodies  >2 publications with PIP5K and Intestine
 Lung Antibodies  >1 publications with PIP5K and Lung
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